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Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin
Fluvial export of organic matter from the terrestrial catchment to the aquatic system is a large and increasing carbon flux. The successful reduction in sulfuric acid deposition since the 1980s has been shown to enhance the mobility of organic matter in the soil, with more terrestrially derived dissolved organic matter (DOM) reaching aquatic systems. Changes in soil acidity also affect the quality
Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking m
Large carnivore populations, such as wolf (Canis lupus) and brown bear (Ursus arctos), have during the last decades increased in Scandinavia. This has led to an intensified debate about the presence of large carnivores as well as about large carnivore policy and management. To some people large carnivores are associated with positive feelings such as interest and joy. To others the presence of lar
We obtained osmotic pressure data of lysozyme solutions, describing their physical states over a wide concentration range, using osmotic stress for pressures between 0.05 bar and about 40 bar and volume fractions between 0.01 and 0.61. The osmotic pressure vs. volume fraction data consist of a dilute, gas-phase regime, a transition regime with a high-compressibility plateau, and a concentrated reg
An enzyme-coenzyme complex was immobilized on the surface of a glassy carbon electrode and investigated with cyclic voltammetry in ethanol-containing buffers. The complex consists of an Liver Alcohol Dehydrogenase molecule to which an NAD-analogue is covalently attached via its straight six-carbon, spacer. One cycle was observed but repeated recycling could not be carried out. presumably due to ca
The main aim of this article is to discuss the attitudes to mathematics of students taking a basic mathematics course at a Swedish university, and to explore possible links between how well such students manage to solve tasks about limits of functions and their attitudes. Two groups, each of about a hundred students, were investigated using questionnaires, field notes and interviews. From the resu
Uncovering customer insights (CI) is indispensable for contemporary marketing strategies. The widespread availability of user-generated content (UGC) presents a unique opportunity for firms to gain a nuanced understanding of their customers. However, the size and complexity of UGC datasets pose significant challenges for traditional market research methods, limiting their effectiveness in this con
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,0
