Filtyp
Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia-inducible factor 1 (HIF-1). HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that reduces oxygen consumption and inhibits the production of potentially harmful reactive oxygen species (ROS). Here, we show that FoxO3A is activated in hypoxia downstream of HIF-1 a
The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two
The global terrestrial carbon cycle plays a pivotal role in regulating the atmospheric composition of greenhouse gases. It has recently been suggested that the upward trend in net primary production (NPP) seen during the 1980's and 90's has been replaced by a negative trend since 2000 induced by severe droughts mainly on the southern hemisphere. Here we compare results from an individual-based glo
Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarb
Climatic conditions during the winter in countries situated in the north can be considered severe. This is especially true for hydraulic structures, such as hydro power structures, dams, harbours, canals and some bridge foundations. Freezing of concrete in contact with unfrozen fresh water may have a considerable impact on the deterioration process of concrete. This paper presents results obtained
The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural
We have developed a method to estimate free energies of reactions in proteins, called QM/MM-PBSA. It estimates the internal energy of the reactive site by quantum mechanical (QM) calculations, whereas bonded, electrostatic, and van der Waals interactions with the surrounding protein are calculated at the molecular mechanics (MM) level. The electrostatic part of the solvation energy of the reactant
The Nordic countries have traditionally been praised for their generous and advanced development policies. Recently, however, it has been claimed that the Nordic model has faded: that the Nordic donors have become more similar to other European donors. One possible reason for such trends is influences from EU policies, that is, Europeanisation. This article critically evaluates such claims by pres
Heavy neutron-rich nuclei were populated via relativistic energy fragmentation of a E/A= 1 GeV Pb-208 beam. The nuclei of interest were selected and identified by a fragment separator and then implanted in a passive plastic stopper. Delayed. rays following internal isomeric decays were detected by the RISING array. Experimental information was obtained on a number of nuclei with Z=73-80 (Ta-Hg), p
Background Primary Sjogren's syndrome (pSS) is an autoimmune rheumatic disease mainly characterised by focal mononuclear cell infiltration in the salivary and lacrimal glands, and by the symptoms xerostomia and keratoconjunctivitis sicca. Germinal centre-like structures (GC) are found in the minor salivary glands of approximately 25% of patients. In this study, we aimed to assess genetic variation
This study of pro-poor solid waste management (conducted in Manila 2006) look at waste both as a health problem and as a livelihood for the poor. Pro-poor solid waste management policies optimize social- environmental- and economic benefits for the poor. In practice, this mean creating job-security for informal waste-pickers (scavengers), establish subsidies to community based recycling schemes an
During April to June 2007 we went to Bangladesh's countryside to collect material for this thesis. The study is qualitative and based on twelve individual interviews. The respondents are members of microfinance organisations or/and an organisation that works with social mobilisation. These organisations aim to increase people's quality of life and fight poverty. The purpose of this study i
In this master's thesis, an attempt is made to automatically predict where people will look when watching video sequences. An application in the form of foveation for video compression is discussed. A relatively simple prediction model is built based on eyetracking data from several subjects and low-level features generated from the video frames, using simple image processing algorithms. The p
Many changes have occurred in the area of immunity for high state officials during the last century. States and their High Representatives, such as Head of State, Head of Government and Foreign Ministers were at the beginning of the last century granted absolute immunities for all acts they conducted. Evolution has, however, produced new rules based more on their need to function properly and less
Idag råder konsensus kring att människans aktivitet bidrar till klimat förändringar. Stater har ingått konventioner, utformat lagstiftning och tagit olika steg för att minska CO2 utsläpp. Statistiskt sett är utsläpp från flyg högre än utsläpp från sjöfart. Sjöfart är dock ett av de större transportsätt för att frakta gods över klotet, därför är det viktigt att utforma en reglering för CO2 utsläpp
