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Brain pericytes not only maintain the anatomical, biochemical and immune blood-brain barrier, but display features of mesenchymal stem cells (MSCs) in vitro. MSCs have pro-regenerative properties attributed to their secretome. However, whether also brain pericytes possess such pro-regenerative capacities is largely unknown. Here we characterize the secretome and microvesicle (MV) release of human
Humidity is an omnipresent climatic factor that influences the fitness, reproductive behavior and geographic distribution of animals. Insects in particular use humidity cues to navigate the environment. Although the sensory neurons of this elusive sense were first described more than fifty years ago, the transduction mechanism of humidity sensing (hygrosensation) remains unknown. Recent work has u
We found that 20 (10.6%) of 188 patients with chronic suppurative otitis media in Angola were co-colonized with fluoroquinolone-resistant Alcaligenes faecalis, commonly found in birds. A likely explanation for our findings was the use of bird feces by residents as a traditional remedy to prevent ear secretions caused by primary ear infection.
The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome-wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour. For such approaches to work in routine practice, the
The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. The thesis gives an overview of the field for network inference and deconvolution methods, as well as a brief background on th
Background. Exposure to lead (Pb) in environmental and occupational settings continues to be a serious public health problem and may pose an elevated risk of genetic damage. Objectives. The aim of this study was to assess the level of oxidative stress and DNA damage in subjects occupationally exposed to lead. Material and methods. We studied a population of 78 male workers exposed to lead in a lea
BACKGROUND: An open access technique might reduce severe vascular and visceral injuries. An open access technique through the umbilical cicatrix tube has been developed as a routine method with the goal to be easy, safe and used by all surgeons in patients without a previous midline incision. AIM: To evaluate the open technique in a prospective study in 100 consecutive laparoscopic operations rega
Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the bra
Comment on: Pfisterer U, et al. Proc Natl Sci USA 2011; 108:10343-8.
Snowmelt induced runoff from river basins is usually successfully simulated using a simple degree-day approach and conceptual rainfall-runoff models. Fluctuations within the day can not be described by such crude approaches. In the present paper, it is investigated which degree of sophistication is required in snow models and runoff models to resolve the basin runoff from basins of different chara
Low aerobic fitness (maximum oxygen uptake (VO(2PEAK))) is predictive for poor health in adults. In a cross-sectional study, we assessed if VO(2PEAK) is related to a composite risk factor score for cardiovascular disease (CVD) in 243 children (136 boys and 107 girls) aged 8 to 11 years. VO(2PEAK) was assessed by indirect calorimetry during a maximal exercise test and scaled by body mass (millilite
In spite of its immune privileged state, xenotransplantation within the CNS is associated with rapid graft destruction in immunocompetent hosts. Efforts to enhance graft survival have mostly focused on host immune response, whereas relatively little attention has been paid to donor tissue characteristics. In the present paper, we explore long-term survival of xenogeneic full-thickness neuroretinal
Using dislocation simulation approach, the basic equation for a finite crack perpendicular to and terminating at a bimaterial interface is formulated. A novel expansion method is proposed for solving the problem. The complete solution to the problem, including the explicit formulae for the T stresses ahead of the crack tip and the stress intensity factors are presented. The stress held characteris
BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their
Abstract is not available
Fracture from a straight crack under mixed mode loading conditions and small scale of yielding is studied. It is assumed that crack growth occurs in either mode I or mode II. Comparison of theoretically obtained values of the mode I stress intensity factor at incipient kinking with experimental results indicates that mode I is preferred to mode II when the loading is such that the crack surfaces a
The subjects of this article are Kozhevnikov and Chistovitch's finding regarding the constancy of relative syllable durations and the inconstancy of relative speech sound durations for different rates of speech, and their proposal that vowels are elided because the necessary minimum duration of a consonant consumes all the time that happens to have been assigned to the syllable. The relative cons
