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The chapter concerns craft thinking as it occurs within the craft making process when the maker is engaged in manipulating the material using the hands and body. The aim is to explain how nonverbal craft thinking enables operating critically and coping with problems such as uncertainty, insufficient information, and insufficient quality within the craft making process. Approaching craft thinking w
Optogenetics is highly useful to stimulate or inhibit defined neuronal populations and is often used together with electrophysiological recordings. Due to poor penetration of light in tissue, there is a need for biocompatible wave guides. Glass wave guides are relatively stiff and known to cause glia reaction that likely influence the activity in the remaining neurons. We developed highly flexible
Carriers of BRCA1 germline pathogenic variants are at substantially higher risk of developing breast and ovarian cancer than the general population. Accurate identification of at-risk individuals is crucial for risk stratification and the implementation of targeted preventive and therapeutic interventions. Despite significant progress in variant classification efforts, a sizable portion of reporte
Introduction: In kidney transplantation (KT), the role of the intravascular innate immune system (IIIS) in response to ischemia-reperfusion injury (IRI) is not well-understood. Here, we studied parallel changes in the generation of key activation products of the proteolytic cascade systems of the IIIS following living donor (LD) and deceased donor (DD) transplantation and evaluated potential assoc
In insects, the odorant receptor (OR) multigene family evolves by the birth-and-death evolutionary model, according to which the OR repertoire of each species has undergone specific gene gains and losses depending on their chemical environment, resulting in taxon-specific OR lineage radiations with different sizes in the phylogenetic trees. Despite the general divergence in the gene family across
Cuerpo-territorio is a method stemming from Latin American geography, which recognizes the centrality of situated and embodied experiences as a form of knowing. We engaged with this method in the classroom to understand how students through their embodied and situated experiences had absorbed a post-development geographic course content and how these notions had remained with them. Given that emot
We consider differential Lyapunov and Riccati equations, and generalized versions thereof. Such equations arise in many different areas and are especially important within the field of optimal control. In order to approximate their solution, one may use several different kinds of numerical methods. Of these, splitting schemes are often a very competitive choice. In this article, we investigate the
Theories of energy justice are standardly used to evaluate decision-making and policy-design related to energy infrastructure. All too rarely attention is paid to the need for a method of justifying principles of justice as well as justice-based judgments that are appealed to in this context. This article responds to this need by offering an engaged ethics approach to normative justification usefu
Numerous assays exist to measure aggressive behaviour in honeybees, most of them using free-flying bees under natural conditions, with results often variable due to environmental factors. Our study describes a novel, laboratory-based Petri dish assay that uses a moving target treated with the alarm pheromone component isoamyl acetate (IAA). In this assay, aggression levels can be measured in indiv
Microtubules are dynamic intracellular fibers that have been observed experimentally to undergo spontaneous self-alignment. We formulate a three-dimensional (3D) mean-field theory model to analyze the nematic phase transition of microtubules growing and interacting within a 3D space, then make a comparison with computational simulations. We identify a control parameter Geff and predict a unique cr
Glucocorticoids (GCs) are essential for mouse embryo implantation and decidualization. Excess GCs are harmful for mouse embryo implantation and decidualization. 11β-Hydroxysteroid dehydrogenases type I and II (Hsd11b1/Hsd11b2) are main enzymes for regulating local level of GCs. Hsd11b2 acts as the placental glucocorticoid barrier to protect the fetus from excessive exposure. Although effects of GC
Background: Many people live with ostomies after life-saving surgery. Ostomy patients often suffer from peristomal dermatitis. Allergic contact dermatitis (ACD) has been reported, mostly due to contact allergy (CA) to topical agents. Objectives: We present three patients with therapy resistant peristomal dermatitis, suggesting ACD caused by different stoma products. Methods: Patch testing was perf
This article discusses the drivers behind why Swedes move to Portugal and who these migrants are. The conceptual framework is based on lifestyle migration and considers migration as a process. Using a semi-structured interview guide, designed according to a life-course approach, 36 in-depth interviews with Swedes permanently residing in Portugal were conducted. The findings display that only a sma
Developing efficient and robust computational models is essential to improve our understanding of protein solution behavior. This becomes particularly important to tackle the high-concentration regime. In this context, the main challenge is to put forward coarse-grained descriptions able to reduce the level of detail, while retaining key features and relevant information. In this work, we develop
This paper calls for renewed consideration of the way researchsubjects are selected in the study of subcultures. All too often,subcultural researchers limit themselves to the use of one or twoof the orthodox sampling designs, such as ‘conveniencesampling’ (selecting subjects who are readily available) or ‘chainreferral sampling’ (selecting a readily available subject who refersthe researcher to ot
Astrocytes have important functions in the brain and their deregulation may cause disease. Current ways to derive astrocytes from pluripotent stem cells are labor, time, and resource intensive, but in this issue of Stem Cell Reports, Li et al. present a faster method to produce functional astrocytes using transcription factors.
Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric diso
