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We have developed a tool, the MAGIC library, which provides an acidification assessment for any given lake or stream in Sweden based on ten parameters describing lake geographical position, surface area, annual discharge and observed lake water chemistry. The MAGIC library consists of two key components: a library of the existing MAGIC model simulations for 2438 lakes and an analogue matching rout

Dynamic polyimine-amide networks with exceptional properties, including high flexibility, excellent thermal stability and dual closed-loop circularity were designed by combining dynamic covalent imine-functionalities with amide-chemistry. The solvent free up-scalable synthesis started from carboxyl-functionalization of lignin-derivable aldehydes followed by melt polycondensation with a triamine to

The design of polymer gears is an open challenge; several constraints must bechecked during the design process due to the complex relations between different design parameters and specifics of application. The failure modes are determined by the load level, used material pair, and operating conditions—speed of rotation, environment temperature, and lubrication. Polymer gear design is not a straigh

ADF/cofilins (AC) are essential F- and G-actin binding proteins that modulate microfilament turnover. The genome of Plasmodium falciparum, the parasite causing malaria, contains two members of the AC family. Interestingly, P. falciparum ADF1 lacks the F-actin binding residues of the AC consensus. Reverse genetics in the rodent malaria model system suggest that ADF1 performs vital functions during

Temperature plays a key role in outdoor industrial cultivation of microalgae. Improving the thermal tolerance of microalgae to both daily and seasonal temperature fluctuations can thus contribute to increase their annual productivity. A long term selection experiment was carried out to increase the thermal niche (temperature range for which the growth is possible) of a neutral lipid overproducing

Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re

Humidity is a critical environmental factor influencing the behaviour of terrestrial organisms. Despite its significance, the neural mechanisms and behavioural algorithms governing humidity sensation remain poorly understood. Here, we introduce a dynamic humidity arena that measures the displacement and walking speed of insects responding to real-time changes in relative humidity (RH). This arena

The IPCC holds the gold standard for climate change scientific knowledge and authority at the science–policy interface. Here we reflect on our experience of the IPCC Sixth Assessment Report and discuss how diversity in authorship and inclusion of different disciplinary backgrounds can be improved.

Heart failure is a leading cause of morbidity and mortality1,2. Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion3–8. Recombinant natriuretic peptide infusions were deve

The background to this article is an interest in what categorisations such as ‘persons with or without disability’ create in terms of inequality and stigma, and how categorisations can support the implementation of Universal Design (UD). The article aims to show how a shift in categorisation can lead to a shift in the conceptualisation of UD, from “inclusive” to “nonclusive” design, i.e., to desig

The tourism industry is likely to face significant challenges stemming from climate change and fluctuations in travel costs. This study investigates the potential impacts of these factors on tourism demand in Fjord Norway, and shows that both environmental conditions and travel expenses play a substantial role in influencing tourism demand. However, tourists exhibit a higher sensitivity to variati

Quantifying intra-person variability in travel choices is essential for the comprehension of activity–travel behaviour. Due to a lack of empirical studies, there is limited understanding of how an individual's travel pattern evolves over months and years. We use two high-resolution user-labelled datasets consisting of billions of GPS track points from ∼3800 individuals to analyse individuals’ acti

Consanguineous marriage is prevalent in certain world regions due to cultural, economic, and social reasons. However, it can lead to negative consequences including an increased risk of genetic disorders in offspring. Premarital genetic screening (PMGS) is an important tool to identify and manage these risks before marriage. This study aimed to assess the magnitude of consanguineous marriage, know

Heterozygous PRRT2 variants are frequently implicated in Self-limited Infantile Epilepsy, whereas homozygous variants are so far linked to severe presentations including developmental and epileptic encephalopathy, movement disorders, and intellectual disability. In a study aiming to explore the genetics of epilepsy in the Sudanese population, we investigated several families including a consanguin

Microtubules are dynamic intracellular fibers that have been observed experimentally to undergo spontaneous self-alignment. We formulate a three-dimensional (3D) mean-field theory model to analyze the nematic phase transition of microtubules growing and interacting within a 3D space, then make a comparison with computational simulations. We identify a control parameter Geff and predict a unique cr