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A reduced number or dysfunction of inhibitory interneurons is a common contributor to neurodevelopmental disorders. Therefore, cell therapy using interneurons to replace or mitigate the effects of altered neuronal circuits is an attractive therapeutic avenue. To this end, more knowledge is needed about how human stem cell-derived GABAergic interneuron-like cells (hdINs) mature, integrate, and func
Metal halide perovskites have shown a great performance in a broad range of optoelectronic devices. The variety of preparation methods makes perovskites especially attractive, yet preparation of complex nanostructures based on these materials remains challenging. Here we present a template assisted method allowing to achieve any pre-designed arrangement of methylammonium lead triiodide (MAPbI3) po
Background: While neuropsychiatric symptoms (NPS) are common in early Alzheimer’s disease (AD), they are currently underdiagnosed and undertreated in the memory clinic. Therefore, we evaluated the effectiveness of the Describe, Investigate, Create, Evaluate (DICE™) approach to structure and standardize the care for NPS in AD in the memory clinic. Method: A total of 60 community-dwelling patients w
This paper presents a production study investigating the frequency of utterance-final rises in South Swedish. These rises are interesting from a dialect typological perspective. Recent findings suggest that South Swedish has two-peak accents utterance medially, whereas previous typologies have assumed only one-peak accents for South Swedish dialects. The South Swedish two-peak accents are similar
The pentasaccharide glycoside corresponding to galactosylgloboside (SSEA-3), β-d-Gal p-(1 → 3)-β-d-Gal pNAc-(1 → 3)-α-d-Gal p-(1 → 4)-β-d-Gal p-(1 → 4)-β-d-Glc p-1-OCH2CH2Si-(CH3)3 (4), was synthesized via glycosylation (87%) of 2-(trimethylsilyl)ethyl 2,3,6-tri-O-benzyl-4-O-[2,3,6-tri-O-benzyl-4-O-(2,4,6-tri-O-benzyl-α-d-galactopyranosyl)-β-d- galactopyranosyl]-β-d-glucopyranoside (2) with the gl
This article contributes guidance on how to approach the development of a course curriculum in general and presents a specific example from medical research education. The purpose of this study is to discuss a model for translating needs assessments of targeted learners into a course curriculum. The model employs established methods for data collection, such as different interview approaches and s
We analyze the determinants of firm-based inventors’ collaborations with universities abroad, comparing them with collaborations with national universities. We propose a micro-founded theoretical framework that introduces the role of personal linkages and global organizational pipelines as drivers of international academic collaborations, and we empirically investigate collaborations with national
Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a hum
BACKGROUND: Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear whether the effects persist to adolescence. Our objective was to assess whether exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age.METHODS: We collected questionnai
Cyanobakterier är urgamla prokaryoter, som finns i en mängd olika livsmiljöer över hela världen. Deras förmåga att utföra fotosyntes (det vill säga att använda solljus, vatten och koldioxid för att producera syre- och kolhydrater) gör dem till viktiga primära producenter, och tillsammans med andra växtplankton utgör de basen för akvatiska näringsvävar.Vid optimala tillväxtförhållandena kan populatCyanobacterial blooms are increasing in occurrence and frequency world-wide, mainly due to eutrophication and increased water temperatures. In freshwater, Microcystis is one of the most common bloom-forming genera, renowned for producing the toxin microcystin which is harmful to humans and other mammals. The ability of Microcystis strains to produce microcystins is largely due to the presence or a
AbstractDead standing trees (DSTs) generally decompose slower than wood in contact with the forest floor. In many regions, DSTs are being created at an increasing rate due to accelerating tree mortality caused by climate change. Therefore, factors determining DST fall are crucial for predicting dead wood turnover time but remain poorly constrained. Here, we conduct a re-analysis of published DST f
As products and supply chains (SCs) evolve, logisticians must revisit their under-standing of postponement. The postponement boundary problem acknowledges that value- adding operations' timing and location in global SCs are critical decisions, impacted by taxes and government regulations in different jurisdictions. However, when combining hardware and software
Ida WingrenMilena Arias Schreiber Sebastian LinkeBreaking out of the neoliberal market agenda? Developing expertise to support local coastal community-based fisheries in SwedenFisheries management lays bare many of the tensions and contradictions between community wellbeing and livelihoods on one hand and impositions of neoliberal market approaches to sustainability on the other. This causes probl
Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-
The main goals of SI are usually to improve learning and student performance as well as increasing retention. The achievement of these goals are evaluated based on linking SI attendance with retention and student results (student performance is here often seen as a proxy for learning). However, the objectives with introducing an SI-program at a higher education institute is often so much more than
BACKGROUND: In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging of the mitral valve, however, is challenging, since it moves in and out of the image plane during the cardiac cycle.PURPOSE: To more accurately measure mitral flow, a slice-following MRI phase contrast sequence is proposed. This study aimed to implement such
