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Background: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. Objective: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on SARS-CoV-2 infection. Designs, settings, and participants: A randomized phase 2 clinical trial (COVIDENZA) enrolled 42 hospitalized COVID-19 patients before safety eva
Background: Post heart-transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause-specific loss of life-years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (I
Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI). Methods: This was a prospective, multicentre,
Objective: Oesophageal atresia is an congenital anomali with incidence of 1/3000-1/4500 live births. The results of reconstructive surgery has improved greatly, to 80-92% survival reported in the last two decades. The aim of this study was to determine the incidence of oesophageal atresia in Iceland and to evaluate the results of operations at the Department of Pediatric surgery at The Children's
Att förstå hur vegetation reagerar på klimatförändringar är viktigt av flera skäl, inte minst eko-nomiska när det gäller träd som är betydelsefulla för skogsbruket såsom gran (Picea abies) och tall (Pinus Sylvest-ris). För att förstå detta behövs kunskap om de mekanismer som ligger bakom trädarternas respons på förändringar i deras levnadsmiljö, vilket man kan få från paleoekologisk forskning baseThe understanding of how vegetation reacts to climate changes can be considered important for many reasons, not least economical when it comes to trees that are important for forestry industry like spruce (Picea abies) and pine (Pinus Sylvestris). To understand this we need knowledge about the mechanics that lie behind these tree species’ responses to changes in their environment, which can be der
Frågan om dödshjälp är en pågående diskussion världen över. I Sverige är assisterat självmord inte straffbart. Eutanasi är däremot förbjudet och bedöms enligt 3 kap 2 § BrB. Denna uppsats syftar till att redogöra för den rättsliga gränsdragningen mellan assisterat självmord och eutanasi samt att analysera denna gränsdragning med hjälp av legalitetsprincipen. Rättsläget presenteras med hjälp av denThe issue of mercy killing is an ongoing discussion worldwide. In Sweden, assisted suicide is not punishable. Euthanasia, on the other hand, is prohibited and judged according to chapter 3 § 2 of the Swedish penal code. This essay aims to account for the legal demarcation between assisted suicide and eutha-nasia and to analyze this demarcation with the help of the principle of legality. The legal
Att tvångsomhänderta ett barn är ett undantag från svensk inställning att vård ska ske genom frivillighet. Det är inget som görs lättvindigt och det krävs att det finns en påtaglig risk för att barnets hälsa eller utveckling annars kommer till skada. Men hur stora krav finns det i samband med vårdens avslutande, var ligger fokus när den bedömningen görs? Syftet med detta arbetet är att titta på föTo take a child into public care against the parents will is an exception from the Swedish standpoint that all care should be given on a voluntary basis. It requires that there is a noticeable risk that the child's health or development will come to harm. But what are the demands when deciding whether the care should come to an end? Where is the focus in that process? The aim of this study is
Dengue is just regular flu but also kills many people all around the world. We all happen to know that dengue viruses have been on the march for the last 100 years. During the late 20th century, it became a serious threat to mankind. Our scientists have been putting their utmost efforts to save people from dengue infections. They have come up with a number of vaccinations and mosquito repellent so
När en person avlider aktualiseras frågor om arvsrätt. Den svenska arvsrätten har ur ett historiskt perspektiv varit starkt påverkad av föreställningar om kön och familjestrukturer. Arvsreglerna är i dag könsneutrala, vilket innebär att varken en arvlåtares eller en arvtagares kön spelar roll vid fördelningen av kvarlåtenskapen. Arvsrätten påverkas dock fortfarande av kön genom den könsfokuserade
Background: High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI).Purpose: To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults presenting to the emergency department (ED) with chest pain.Data Sources: EMBASE
Background: One way to measure quality of care is by measuring satisfaction of provided care among patients and their families. EMpowerment of PArents in THe Intensive Care 30 (EMPATHIC-30) is a self-reported questionnaire grounded on the principles of FCC aiming to measure parents' satisfaction with paediatric intensive care. There is lack of Swedish questionnaires measuring satisfaction with pae
In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role
Objectives: To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data. Methods: All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome
Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 co
Background: The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net. Methods: We conducted a retrospective cohort study of adult
Background: The treatment strategy for proximal aortic disease or type I endoleak after previous infrarenal repair has traditionally been open surgery. As endovascular treatment options with fenestrated and branched stent grafts increasingly rival open surgery for juxtarenal and pararenal aortic aneurysms, secondary proximal repair may similarly be performed endovascularly. Fenestrated stent graft
Objective: Worse women's outcomes after elective standard endovascular aneurysm repair have been widely reported. Similar data have surfaced from cohorts undergoing fenestrated and branched repair; however, studies reporting from a sex perspective are rare and mostly limited to single centre designs. This study aimed to examine survival following nationwide complex endovascular repair according to
