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Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal

Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography

Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac

Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on

Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin

Arbetsrehabilitering Efterfrågan på evidensbaserade insatser har ökat markant i Sverige och Individual Placement and Support (IPS) är en av de högst prioriterade psykosociala insatserna i Socialstyrelsens nationella riktlinjer. Utbildningen har gått regelbundet sedan 2012 och fokuserar nu även på Supported Education. Särskild tonvikt i utbildningen kommer att läggas vid implementeringen av IPS i b

https://www.medicin.lu.se/sites/medicin.lu.se/files/uppdragsutbildning_ips_ht_2020.pdf - 2026-04-26

A distinguishing feature of youth detention homes—and any other prisonlike institution—is the fact that inmates cannot just leave. They might escape, and there are ways to be transferred, enjoy an excursion, and get permission for home visits, but typically the young people in this case are supposed to remain within their given institution. I have been eager to not only depict this feature of fiel

Background:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care c

CRISPRideas TEMA 2019-2020 Utvecklingen av nya genredigeringstekniker som CRISPR-Cas9 har skapat en revolution inom biologisk och medicinsk forskning. De innebär möjligheter att göra precisa och riktade förändringar i arvsmassan på alla slags organismer, från mikroorganismer till människor. Inom växtförädlingen finns förhoppningar att kunna utveckla nya grödor som är bättre anpassade till ett fram

https://www.pi.lu.se/sites/pi.lu.se/files/2021-01/CRISPR%20SVE.pdf - 2026-04-26

FRAF21 Franska: Grundkurs i Frankrike Semestre d’automne 2025 Hitta (student)boende i Toulouse Trouver un logement (étudiant) à Toulouse Detta dokument är tänkt som ett stöd för de studenter från Lunds universitet som kommer att åka till Université de Toulouse Jean Jaurès för att läsa franska under höstterminen 2025. Dokumentet innehåller information om hemsidor och länkar som hjälper er att komma

https://www.sol.lu.se/fileadmin/user_upload/sol/aemnen/sektion3/Logement_%C3%A9tudiant_%C3%A0_Toulouse_HT2025.docx - 2026-04-25

https://www.mhm.lu.se/internt/exchange-studies - 2026-04-25