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Screening for type 1 diabetes (T1DM) risk in newborns has little negative emotional impact on mothers. In this study, the impact on the mother and the father was evaluated both in the general population and in families with diabetes. All parents with a newborn in Skåne, Sweden, were invited to a screening for T1DM risk in their children (the Diabetes Prediction in Skåne (DiPiS)). Blood was obtaine

Abstract in UndeterminedThe recent MPEG Reconfigurable Media Coding (RMC) standard aims at defining media processing specifications (e.g. video codecs) in a form that abstracts from the implementation platform, but at the same time is an appropriate starting point for implementation on specific targets. To this end, the RMC framework has standardized both an asynchronous dataflow model of computat

The topic of the thesis is re-initialization of multistep methods for the solution of ordinary differential equations, in which there are frequent discontinuities in first or higher derivatives. There are self-starting algorithms to start or restart a multistep method. It is normally started by first using a one-step method and then increasing the order successively until the working order is reac

Under 1990-talet genomfördes flera omdiskuterade humanitära interventioner. De som var kritiska hävdade att interventionerna var en oacceptabel kränkning av suveränitetsprincipen. Förespråkare menade att respekten för mänskliga rättigheter var ett viktigare intresse att skydda. 2001 släpptes en rapport som fick stor betydelse för den globala utvecklingen på området. I rapporten lanserades koncepteDuring the 1990s there were several controversial humanitarian interventions. Critics argued that the interventions were an unacceptable violation of the principle of sovereignty. Proponents argued that the respect for human rights was an interest of more importance. In 2001 a report that was of great importance for the continued global development was released. The report launched the concept of

Due to the relatively short duration of earthquakes, most studies simplify their impact on structures by considering the total effect of each event rather than modelling the instantaneous accumulation of damage during the event itself. This approach may underestimate performance degradation, as incremental damage occurring during the shock can lead to an immediate reduction in capacity. Furthermor

Sustainable access to effective antibiotics is a main rationale for addressing antimicrobial resistance, for calls to enhance antibiotic supply security and for development support to promote health system capacity in low- and middle-income settings. Standard models for valuing pharmaceuticals fail to capture the full value of sustainable access to effective antibiotics. In effect, assessments of

Popular Abstract in Swedish Elektroencefalogrammet (EEG), dvs mätning av potentialer på skalpen, är en relativt enkel och gammal teknik för att studera hjärnans aktivitet. Trots de stora framstegen inom s k brain-mapping-tekniker på senare år (magnetröntgen, PET, SPECT), är EEG fortfarande ett viktigt verktyg för diagnos. En av dess fördelar gentemot andra tekniker är dess fina tidsupplösning. EtThe thesis treats methods for pattern recognition in multichannel electroencephalogram (EEG) signals, for application to diagnostics of epilepsy. Parts I-IV treat methods for feature extraction and clustering of EEG spikes, occurring between epileptic seizures, and part V presents a method for filtering seizure onset EEG signals. In part I, Hermite functions are used for parametric description of

Empiriskt undersöka principal-agent-teorins relevans i komplexa och kunskapsintensiva ”business to business” relationer. Med en induktiv ansats genomförs en kvalitativ fallstudie. Insamlad data har analyserats med hjälp av ”pattern matching”, med potentiella förklaringsvariabler på förhand identifierade genom en marknadsanalys, omfattande litteraturstudie och en pilotintervju, vilket har mynnat ut

In this paper, we present a global solution to a nonlinear H-infinity optimal control problem for control-affine systems with an associated potential function. We also give a closed-form expression for an optimal controller and demonstrate its potential for sparsity. This paper thus advances a recent result which considers the same problem restricted to systems with symmetric state matrix and nonl

Flicker, or more precisely temporal light modulation (TLM), has re-emerged as a problem with the introduction of LED-based lighting technology. TLM, meaning variations in light intensity over time, may have negative effects on human health, causing annoyance, headaches, eyestrain and migraine. In addition to the unnecessary suffering TLM causes in individuals, the negative consequences of TLM crea

This tutorial presents an introduction to power scaling concepts for high-order harmonic generation (HHG) and attosecond pulse production. We present an overview of state-of-the-art HHG-based extreme ultraviolet (XUV) sources, followed by a brief introduction to basic principles underlying HHG and a detailed discussion of macroscopic effects and scaling principles. Particular emphasis is put on a

The NA62 experiment at CERN reports searches for K+→μ+N and K+→μ+νX decays, where N and X are massive invisible particles, using the 2016–2018 data set. The N particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of O(10−8) of the neutrino mixing parameter |Uμ4|2 for N masses in the range 200–384 MeV/c2 and lifetime exceeding 50 ns. The X particle is consi

PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and chloramphenicol, which stall translating ribosomes when certain amino acids are present at a defined position in the nascent polypeptide chain. These proteins are often encoded on mobile genetic elements, facilitating their rapid s

The Cochrun-Grabel (C-G) method, an algorithm for finding the characteristic polynomial of a circuit containing reactances, has so far been restricted to circuits not employing mutual inductances. In this paper we present an intuitive, yet rigorous, proof of the Cochrun-Grabel method for a general RLC circuit, and we extend the method to allow the analysis of an RLC circuit containing mutual induc

The Myc oncoprotein is tightly regulated at multiple levels including ubiquitin-mediated protein turnover. We recently demonstrated that inhibition of Cdk2-mediated phosphorylation of Myc at Ser-62 pharmacologically or through interferon (IFN)-γ-induced expression of p27Kip1 (p27) repressed Myc's activity to suppress cellular senescence and differentiation. In this study we identified an additiona