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De första städerna.

Städer i sin snävaste betydelse är ett sentida fenomen. Eftersom de vuxit fram under en process är de inte så entydigt definierade som vi i nutiden antar. Problemet blir tydligt när vi tvingas omnämna orter som ”proto-urbana” eller använda begrepp som ”centralplatser”. Dessa begrepp antyder att livsmönstret inte riktigt utvecklats till en ”riktig” stad eller att det embryonala urbana livsmönstret

Glacial history and palaeo-environmental change of southern Taimyr Peninsula, Arctic Russia, during the Middle and Late Pleistocene

We here reconstruct a glacial and climate history of arctic NW Siberia for the last ~600,000 years, based on the stratigraphy and chronology of 35 studied river sections on the southern Taimyr Peninsula. From this stratigraphic mosaic we have identified four glacial events, marked by tills/glaciotectonics, which are intercalated with mainly marine sediments deposited in proglacial settings during

Risk factors for development of neurocognitive disorders

Vascular risk factors are believed to be involved in dementia development by increasing risk of the most common dementia types, Alzheimer’s disease (AD) and vascular dementia. The aim of this thesis was to study if risk factors affect key brain pathology directly, by using biomarkers for dementia in preclinical stages, and to assess previous findings in a large population-based setting.Paper I: ar

Iran: A Clash of Two Cultures?

Since the 1979 Revolution, the clerical regime in Iran has been limiting the legal profession’s autonomy by preventing members of the Iranian Bar Association (IBA) from freely electing their Board of Directors and by establishing a new body of lawyers—legal advisors of the judiciary—to contest the IBA’s professional monopoly. Clerics have even attempted to bring the legal profession under the contSince the 1979 Revolution, the clerical regime in Iran has been limiting the legal profession’s autonomy by preventing members of the Iranian Bar Association (IBA) from freely electing their Board of Directors and by establishing a new body of lawyers—legal advisors of the judiciary—to contest the IBA’s professional monopoly. Clerics have even attempted to bring the legal profession under the cont

Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor

The effects of changing NMDA receptor subunit composition on synaptic plasticity in the hippocampus were analyzed by creating transgenic mice overexpressing NR2D, a predominantly embryonic NMDA receptor subunit. NMDA-evoked currents in the transgenic mice had smaller amplitudes and slower kinetics. The transgenics also displayed age-dependent deficits in synaptic plasticity in area CA1 of the hipp

Hospital volumes and later year of operation correlates with better outcomes in acute Type A aortic dissection

OBJECTIVES: Acute Type A aortic dissection remains a life-threatening disease, but there are indications that its surgical mortality is decreasing. The aim of this report was to study how surgical mortality has changed and what influences those changes.METHODS: Nordic Consortium for Acute Type A Aortic Dissection is a retrospective database comprising 1159 patients (mean age 61.6 ± 12.2 years, 68%

Adipocytes and Obesity-Related Conditions Jointly Promote Breast Cancer Cell Growth and Motility : Associations With CAP1 for Prognosis

The global increase in overweight and obesity rates represent pressing public health concerns associated with severe comorbidities, amongst a rising incidence and impaired outcome of breast cancer. Yet, biological explanations for how obesity affects breast cancer are incompletely mapped. Herein, the joint impact by differentiated 3T3-L1 adipocytes and obesity-related metabolic conditions on breas

Brain injury markers in blood predict signs of hypoxic ischaemic encephalopathy on head computed tomography after cardiac arrest

Background/Aim: Signs of hypoxic ischaemic encephalopathy (HIE) on head computed tomography (CT) predicts poor neurological outcome after cardiac arrest. We explore whether levels of brain injury markers in blood could predict the likelihood of HIE on CT. Methods: Retrospective analysis of CT performed at 24–168 h post cardiac arrest on clinical indication within the Target Temperature Management

Koncessionsplikten - i kollision med utbyggd mikroproduktion

Syftet med detta projekt har varit att analysera huruvida, och i sådana fall på vilket sätt, koncessionsplikten hämmar förutsättningarna för småskalig elproduktion, främst mikroproduktion. I detta ingår också att komma med förslag på hur juridiska och regleringsmässiga förändringar skulle kunna se ut för att öka möjligheterna för transitering av lokalt producerad energi. Studien har framförallt ba

Tjänsteinnovation i välfärdens vardag Förutsättningar för innovationsarbete i socialtjänst och skola

I den här forskningsrapporten har vi velat pröva och utveckla utgångspunkterhämtade från tjänstelogik i arbete med innovation inom välfärd. Växandeungdomskriminalitet och ökande psykisk ohälsa är bara två exempel på effekter avcsamhällsförändringar som utmanar den offentligt finansierade välfärden och får dencatt söka nya tillvägagångssätt. I detta sökande efter framgångsrika sätt att förändracväl

Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia.

BACKGROUND:There are limited data on the treatment outcomes of adolescents living with HIV. Our objective was to compare mortality and loss to follow up (LTFU) rates between adolescent and younger age groups at enrollment in care.METHODS:This was a retrospective cohort study carried out in eight health facilities in two regions of Ethiopia. Adolescents (age 10-14 and 15-19 year) and children (age BackgroundThere are limited data on the treatment outcomes of adolescents living with HIV. Our objective was to compare mortality and loss to follow up (LTFU) rates between adolescent and younger age groups at enrollment in care.MethodsThis was a retrospective cohort study carried out in eight health facilities in two regions of Ethiopia. Adolescents (age 10–14 and 15–19 year) and children (age 0–

A load frame for in situ tomography at PETRA III

A load frame for in situ mechanical testing is developed for the microtomography end stations at the imaging beamline P05 and the high-energy material science beamline P07 of PETRA III at DESY, both operated by the Helmholtz- Zentrum Geesthacht. The load frame is fully integrated into the beamline control system and can be controlled via a feedback loop. All relevant parameters (load, displacement

Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit

PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU.METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up.RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withho

Fortsatta erfarenheter av teduglutidbehandling vid extrema kort tarm syndrom i Skåne och Blekinge

Abstraktinlämning NutritionGastrodagarna-1027Fortsatta erfarenheter av teduglutidbehandling vid extrema kort tarm syndrom i skåne och blekinge.Å Nilsson* 1, G Hoffmann2, M Söderholm3, L Zhou11Gastroenterologisektionen, Skånes Universitetssjukhus, Lund, 2Medicin, Gastroenterologi, Centralsjukhuset, Kristianstad, 3Kirurgiska Kliniken, Blekingesjukhuset, Karlskrona, SverigeBakgrund: Teduglutid (Reves

Metabolism of 3H labelled arachidonic acid and 14C labelled linoleic acid in essential fatty acid deficient rats

Mesenteric duct chylomicrons labelled with [3H]arachidonic (20:4) and [14C]linoleic (18:2) acid were injected intravenously into essential fatty acid-deficient (EFAD) and control rats. The rats were killed after 5, 10, 20 and 240 min, and serum and different organs were analysed for radioactivity of different lipid classes. 3H and 14C in the triacylglycerol (TG) and phosphatidylethanolamine (PE) f

Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling

Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the downstream mechanisms involved at different developmental windows and in different central nervous system (CNS) tissues have remained elusive. Approach and Results- Here, we create a new mouse model allowing spatiotemporal investigations of Wnt/β-catenin signaling by induced overexpression of Axin1, a

Om försäkringstagares skyldigheter - En kritisk granskning av försäkringstagares skyldigheter under skaderegleringen enligt 8 kap. 19 § FAL

The Swedish regulation of insurance law is largely intended to protect weaker contracting parties and to ensure that insured persons receive the protection for which they pay. It may, however, be difficult for a policyholder to know what is required in order to invoke the insurance cover. Pursuant to Chapter 8, Section 19 of the Insurance Contracts Act (FAL), a poli-cyholder who is a business oper

Frivilliga avnoteringar och god sed på aktiemarknaden - En analys av Aktiemarknadens självregleringskommitté nya regelverk

Denna uppsats behandlar frågan om frivilliga avnoteringar av aktier från re-glerade marknader och analyserar det nya regelverk som infördes av Aktie-marknadens självregleringskommitté (ASK) och trädde i kraft den 1 septem-ber 2025. Bakgrunden till uppsatsen är den markanta ökningen av antalet av-noteringar på den svenska aktiemarknaden under senare år, samt behovet av ett mer enhetligt och förutseThis thesis examines voluntary delistings of shares from regulated markets and analyses the new regulatory framework introduced by the Swedish Stock Market Self-Regulation Committee (Aktiemarknadens självregleringskommitté, ASK), which entered into force on 1 September 2025. The background to the thesis is the marked increase in the number of delistings on the Swedish securities market in recent y

Skandinaviskt mottagande och användande av Montesquieus maktdelningslära - En analys av Montesquieus maktdelningslära och hur den användes i de skandinaviska författningarna introducerade mellan 1809 och 1849

During the first half of the nineteenth century new constitutions were adopted in all Scandinavian countries. Sweden introduced the 1809 Instrument of Government, followed by the Norwegian Constitution of 1814 and the Dan-ish Constitution of 1849. These constitutional reforms took place during a time of significant development in constitutional theory. One of the theorists who contributed to these

De lottlösa - Om kusiners och sambors arvsrätt ur ett nordiskt perspektiv

Kusiner förlorade sin arvsrätt med 1928 års arvslag och står än idag utanför den allmänna arvsordningen. Sambor har aldrig tagits upp in i den till att börja med. Syftet med uppsatsen är att undersöka arvsrätten för kusiner och sambos i svensk rätt. Grupperna har gemensamt att de ofta står den avlidna men samtidigt utanför den allmänna arvsordningen. Frågorna som ställs handlar om hur synen på kCousins lost their right of inheritance with the 1928 Inheritance code and remain outside the general order of succession to this day. Cohabiting partners have never been included in it to begin with. The purpose of this essay is to examine the right of inheritance for cousins and cohabiting partners in Swedish law. The two groups have in common that they are often close to the deceased, yet the