Multimodal Gene Expression Deep Learning for Predicting Sentinel Lymph Node Macro-metastasis in Early Breast Cancer: Development and Validation in the SCAN-B Cohort
Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva
