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The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we screened markers for patterns indicative of interactions (relationship loci [rQTL] and variance heterogeneity loci [vQTL]). rQTL exist when the correlation between multiple traits varies by genotype and vQTL occur when the variance of a trait

Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the

Background: The rising prevalence of dementia represents an important public health issue. There is currently no available cure for dementia disorders, only symptom-relieving therapies which can be either pharmacological or non-pharmacological. The number of non-pharmacological interventions for patients with dementia disorders and their caregivers have been increasing in recent years without much

Chronic Obstructive Pulmonary Disease (COPD) is often caused by smoking and other stressors. This causes oxidative stress, which induces numerous changes on both the transcriptome and proteome of the cell. We aimed to examine if the endomembrane pathway, including the endoplasmic reticulum (ER), Golgi, and lysosomes, was disrupted in fibroblasts from COPD patients as opposed to healthy ever-smoker

Objective: To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden. Methods: All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998-2014 were identified. Non-gout crystal arthropathy (ICD-10 codes M11.0-M11.9) was subclassifie

By examining the arguments presented in courts and in print media to support and oppose the introduction of conscientious objection for healthcare workers in Sweden, this article illustrates the ways in which interest groups may take advantage of expanding opportunity structures in the wake of internationalization, all the while framing their arguments in ways that create resonance with national a

This textbook advocates patients’ empowerment for improving health outcomes and health system performance. It emphasizes the important implications of improving communication between patient and health professionals and the adherence to treatment regimens. Based on research including theories of Stages of Change and Decision Balance, and by incorporating examples from daily clinical practice, this

The datasets presented here enable historical longitudinal studies of micro-level geographic factors in a rural setting. These types of datasets are new, as historical demography studies have generally failed to properly include the micro-level geographic factors. Our datasets describe the geography over five Swedish rural parishes and a geocoded population (at the property unit level) for this ar

INTRODUCTION: Cardiovascular disease (CVD) is a major cause of death in people aging with spinal cord injury (SCI), and is predominantly caused by atherosclerosis, however, knowledge of atherosclerosis in people with SCI is scarce.OBJECTIVE: To describe coronary and carotid atherosclerosis in middle-aged people with long-term cervical and upper thoracic SCI using coronary computed tomography angio

Using functional imaging and neural circuit reconstructions, a recent study reveals head direction neurons in the anterior hindbrain of zebrafish that resemble insect head-direction cells to a surprising degree.

The circulation is a closed system that has been assumed to be free from bacteria, but evidence for the existence of a low-density blood microbiota is accumulating. The present study aimed to map the blood microbiota of outpatients with Crohn’s disease (CD) or with ulcerative colitis (UC) by 16S metagenomics. A diverse microbiota was observed in the blood samples. Regardless of the type of disease

It has been a mystery that the detected fluorescence intensity of single MEH-PPV molecules is much lower than expected based on their chain length. In this review, after re-evaluating of the literature data in the light of new specially designed experiments, we present a comprehensive explanation of this issue: The actual size of MEH-PPV molecules at single molecule level is much smaller than expe

Tendons are collagen-based connective tissues where the composition, structure and mechanics respond and adapt to the local mechanical environment. Adaptation to prolonged inactivity can result in stiffer tendons that are more prone to injury. However, the complex relation between reduced loading, structure, and mechanical performance is still not fully understood. This study combines mechanical t

Attosecond photoelectron spectroscopy has opened up for studying light–matter interaction on ultrafast time scales. It is often performed with interferometric experimental setups that require outstanding stability. We demonstrate and characterize in detail an actively stabilized, versatile, high spectral resolution attosecond beamline based on a Mach-Zehnder interferometer. The active stabilizatio

Background: The development of entrustable professional activities (EPAs) as a framework for work-based training and assessment in undergraduate medical education has become popular. EPAs are defined as units of a professional activity requiring adequate knowledge, skills, and attitudes, with a recognized output of professional labor, independently executable within a time frame, observable and me

A 1-m normal-incidence monochromator has been designed and installed on a bending-magnet beam line at the MAX storage ring in Lund. The optical properties of the beam line have been investigated via ray-tracing studies and with flux measurements of the beam line-monochromator combination. A resolution of 0.9 Å at 919.8 Å was measured in first-order diffraction with an argon hollow-cathode lamp for

Air pollution is a major contributor to the global burden of disease and has been linked to several diseases and conditions, including cardiovascular disease. The biological mechanisms are related to inflammation and increased coagulability, factors that play an important role in the pathogenesis of venous thromboembolism (VTE, i.e., deep vein thrombosis or pulmonary embolism). This study investig

Various mechanisms have been proposed for hydrogen embrittlement of duplex stainless steel, but the causation of hydrogen-induced material degradation has remained unclear. This work shows that phase instability (decomposition) of the austenite phase and ductile-to-brittle transition of the ferrite phase precedes hydrogen embrittlement. In-situ diffraction measurements revealed that Ni-rich sites