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Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA- DR3 haplotype (DRB1*03:01-DQA1*05:01-DQB1*02:01). Studies of two different populations have recently documented that T1D susceptibili

Axially heterostructured nanowires (NWs) constitute a promising platform for advanced electronic and optoelectronic nanodevices. The presence of different materials in these NWs introduces a mismatch resulting in complex strain distributions susceptible of changing the band gap and carrier mobility. The growth of these NWs presents challenges related to the reservoir effect in the catalysts drople

Transition metal complexes play a crucial role in solar energy conversion. These coordination compounds have promising applications in dye-sensitized solar cells and photocatalysis, with particular interest in solar fuel production. However, many of the photoactive transition metal complexes used in light-harvesting applications are still based on rare and expensive metals from the transition meta

Targeted delivery of α-synuclein using AAV vectors has over the two decades since its introduction developed into a versatile tool for modeling different aspects of synucleinopathy, mimicking those seen in Parkinson's disease and related Lewy body disorders. The viral vector approach to disease modeling is attractive in that the expression of α-synuclein, wild-type or mutated, can be confined to d

IMPORTANCE Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality. OBJECTIVE To study the association between sodium intake and incident atrial fibrillation (AF). DESIGN, SETTING, AND PARTICIPANTS This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global End

Acoustic streaming shows great potential in applications such as bubble dynamics, cell aggregation, and nanosized particle isolation in the biomedical and drug industries. As the acoustic shock distance decreases with the increase of incident frequency, the nonlinear propagation effect will play a role in acoustic streaming, e.g., Eckart (bulk) streaming at a few gigahertz. However, the theory of

Objective: To determine if prior exposure to certain drugs is associated with increased risk of ANCA associated vasculitis(AAV).Patients and Method: We performed a population-based case–control study including patients with AAV diagnosed between2006 and 2019 from a defined geographic area in southern Sweden. For each case, we identified 10 controls randomly sampledfrom the background general popul

OBJECTIVES: Carbapenem- and colistin-resistant Klebsiella pneumoniae were isolated from war victims treated in hospitals in Ukraine. The question was whether these pandrug-resistant K. pneumoniae are pathogenic and capable of causing disease in a broader context.METHODS: Klebsiella pneumoniae clinical isolates (n = 37) were tested for antibiotic resistance and subjected to whole-genome sequencing

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, hi

Multi-junction photovoltaics approaches are being explored to mitigate thermalization losses that occur in the absorption of high-energy photons. However, the design of tandem cells faces challenges such as light reflection and parasitic absorption. Nanostructures have emerged as promising solutions due to their anti-reflection properties, which enhances light absorption. III-V nanowires (NWs) sol

The purpose of the thesis is to examine to what extent former high ranking state officials are immune for international crimes before foreign national courts. Historically national courts have recognized absolute immunity, but this approach has gradually to some extent changed after the establishment of international tribunals and the International Criminal Court in which official capacity is irre

The aim of this thesis is to gather an understanding of the creation of unlikely alliances within the environmental movement as a social movement. This is done in turn done by looking at the resistance among the environmental movement as well as grassroots organizations that arose around the proposal to build a pipeline called Keystone XL made by the Canadian oil company TransCanada in 2008. The f

Diploid potato cultivars that are propagated by True Potato Seeds (TPS) are a new potentially revolutionary way of potato breeding. Conventional breeding is based on highly heterozygous tetraploid potato varieties. Diploid potato breeding by TPS is useful to create inbred lines and from there hybrid offspring. TPS is cheaper, has almost no diseases and is easy to distribute. Diploid potatoes have Are potatoes, grown from seeds, the future? Did you know that you can grow potato plants from seeds? A potato plant has two ways to propagate itself; by the all known potato that we love to eat and by seeds that are grown in tomato-like berries above the ground. These seed producing potato plants that are as well diploid (two copies of every chromosome) instead of conventional tetraploid (4 copie

The aim of this study was to investigate the motivational work in needle exchanges. The analysis was based on two theories; a theory of Per Revstedt and the pygmalioneffect. The study is based on qualitative interviews with seven person (six women and one man) who work in needle exchanges. The interviews is later analysed. The results show that the respondents express that the goal with the motiva

The nomadic pastoralists of the Sahel are often identified as a group at the frontline of global climate change. Their existence in arid and semi-arid regions and their reliance on seasonal rainfall are among the factors that contribute to their vulnerability to drought and climate shocks. This study focuses on risks to pastoralists in Sudan, asking whether index-based livestock insurance, an innoPastoralism is a nomadic lifestyle and a livelihood system that revolves around raising livestock. By migrating seasonally in search of water and pasture for their animals, pastoralists are able to inhabit and make productive use some of the world’s harshest environments. In Sudan, where over 90% of the vast land area is covered by desert and drylands, pastoralism remains a vital feature of the co

The focus of my thesis has been the Swedish lay judges. My purpose has been to examine the Swedish system of lay judges and furthermore study it in relation to legal certainty. My major problem statement has been: In accordance with legal certainty, what advantages and disadvantages can be seen with the system of lay judges? The Swedish lay judges participate primarily in district and appellate c

My thesis ’’Responsibility to create sustainability – a concept analysis of responsibility in the sustainability reports of the Swedish fashion industry’’, investigates Hennes & Mauritz and Filippa Ks view of the concept responsibility in sustainability reports, be- fore and after the adoption of The Sustainable development goals. The purpose of this study is to uncover if the enterprises view

Syfte: Huvudsyftet med studien var att undersöka den phonicsbaserade lärappen GraphoLearns effekter på avkodningsförmågan hos svensktalande barn i tidig läsutveckling. Sekundärt var syftet att undersöka huruvida träning med GraphoLearn kan påverka hjärnstruktur. Studien kan betraktas som en pilotstudie för ett större pågående projekt. Metod: Fjorton deltagare i åldrarna 6 till 7 år inkluderades. S