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Animal serum is often used to generate human macrophages in vitro. Since fetal calf serum (FCS) may complicate antigen uptake, processing and presentation on HLA molecules, we tested the ability of M-CSF to generate macrophages at low fetal calf serum conditions. Peripheral blood monocytes from 12 individuals were cultured 1-4 days with 0-100 ng/ml macrophage colony stimulating factor (M-CSF) at e
The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 di
Modelling the distribution of migratory species has rarely been extended beyond breeding and wintering ranges despite many species showing much more complex movement patterns with multiple stopovers. We aimed to create a temporally explicit species distribution model describing the full annual distribution cycle, and use it to model the complex seasonal shifts in distribution of the common cuckoo
The intramedullary skeletal kinetic distractor (ISKD) is one of the relatively recent methods developed to overcome the complications of conventional bone lengthening methods, such as external fixators. These complications include pain, muscle transfixation, pin-tract infection, reduced joint motion, and prolonged fixation time. However, ISKD-specific complications such as uncontrollable lengtheni
En grundläggande fråga i den allmänna förvaltningsrätten är var gränserna ska gå för möjligheten att ändra meddelade beslut. I svensk förvaltningsrätt har denna fråga traditionellt besvarats med hjälp av principer om (förvaltningsrättslig) negativ rättskraft. I EU-rätten har det däremot under inflytande av andra medlemsstaters rättstraditioner utvecklats en unionsrättslig princip om skydd för berä
Electric Hybrid Vehicles (EHVs) play a crucial role in the development towardsa more environmental friendly transportation. An alternative to solve someactual challenges with hybridization of vehicles is studied at the Division ofIndustrial Electrical Engineering and Automation (IEA) at Lund Universityin cooperation with the automotive industry. A key component of this drivetrain is a highly dynam
An arabinose specific xylanase from glycoside hydrolase family 5 (GH5) was used to hydrolyse wheat and rye arabinoxylan, and the product profile showed that it produced arabinose substituted oligosaccharides (AXOS) having 2-10 xylose residues in the main chain but no unsubstituted xylooligosaccharides (XOS). Molecular modelling showed that the active site has an open structure and that the hydroxy
The migration of aerofauna is a seasonal phenomenon of global scale, engaging billions of individuals in long-distance movements every year. Multiband lidar systems are commonly employed for the monitoring of aerosols and atmospheric gases, and a number of systems are operated regularly across Europe in the framework of the European Aerosol Lidar Network (EARLINET). This work examines the feasibil
Fabless production, meaning manufacturing without owning fabrication facilities, has been suggested as a novelty by the semiconductor industry. However, Ikea, the global furniture company based in Sweden, has successfully been producing their furniture in a fabless fashion since 1955. This paper explores how Ikea manage and control its almost fabless production to reach the company’s targets for s
In T lymphocytes, lipid rafts are preferred sites for signal transduction initiation and amplification. Many cell membrane receptors, such as the TCR, coreceptors, and accessory molecules associate within these microdomains upon cell activation. However, it is still unclear in most cases whether these receptors interact with rafts through lipid-based amino acid modifications or whether raft insert
The configuration of value chains and value systems is of vital importance for the long-term competitiveness and survival of companies. The focus of the study is value systems involving a leading Company. Our main question is: How do leading companies configure boundless value systems?
Routine monitoring of workplace exposure to polycyclic aromatic hydrocarbons (PAHs) is performed mainly via active sampling. However, active samplers have several drawbacks and, in some cases, may even be unusable. Polyurethane foam (PUF) as personal passive air samplers constitute good alternatives for PAH monitoring in occupational air (8 h). However, PUFs must be further tested to reliably yiel
Theory on plasticity driving speciation, as applied to insect–plant interactions (the oscillation hypothesis), predicts more species in clades with higher diversity of host use, all else being equal. Previous support comes mainly from specialized herbivores such as butterflies, and plasticity theory suggests that there may be an upper host range limit where host diversity no longer promotes divers
This paper discusses the application of university extension practice in the establishment of new tourism enterprises, with a particular focus on culinary tourism enterprises. The discussion is framed by the ‘missions’ perspective of university function, noting that extension is a form of knowledge transfer falling within the ‘Third Mission’ of universities. A case study approach is used to show h
Many natural and industrial proteins are known to have properties that can result in type I hypersensitivity, however, to date, no validated test system exists that can predict the sensitizing potential of these allergens. Thus, the objective of this study was to develop a protocol based on the myeloid cell-based Genomic Allergen Rapid Detection (GARD) assay that can be used to assess and predict
Objectives. Comparisons between remote magnetic (RMN) and manual catheter navigation for atrial fibrillation (AF) ablation have earlier been reported with controversial results. However, these reports were based on earlier generations of the RMN system. Design. To evaluate the outcomes of the most current RMN system for AF ablation in a larger patient population with longer follow-up time, 112 pat
The nuclear physics facility at MAX-lab requires high energy electrons for photonuclear experiments. These electrons are first accelerated in two LINACs that are fed via a SLED system. Arcing in the waveguide structures is currently the limiting factor of the available electron energy. In this report, the implementation of a phase modulation scheme into the injector system is presented. This makes
