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The gut microbiota and diabetes : research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in

Fermion-parity qubit in a proximitized double quantum dot

Bound states in quantum dots coupled to superconductors can be in a coherent superposition of states with different electron number but with the same fermion parity. Electrostatic gating can tune this superposition to a sweet spot, where the quantum dot has the same mean electric charge independent of its electron-number parity. Here, we propose to encode quantum information in the local fermion p

Data quality and patient characteristics in European ANCA-associated vasculitis registries : data retrieval by federated querying

Objectives This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic antibody-associated vasculitis (AAV) registries. Methods Through creation of the vasculitis-specific Findable, Accessible, Interoperable, Reusable, VASCulitis ontology, we harmonised

Probing Majorana localization in minimal Kitaev chains through a quantum dot

Artificial Kitaev chains, formed by quantum dots coupled via superconductors, have emerged as a promising platform for realizing Majorana bound states. Even a minimal Kitaev chain (a quantum dot-superconductor-quantum dot setup) can host Majorana states at discrete sweet spots. However, unambiguously identifying Majorana sweet spots in such a system is still challenging. In this work, we propose a

Switchable Broadband Terahertz Absorbers Based on Conducting Polymer-Cellulose Aerogels

Terahertz (THz) technologies provide opportunities ranging from calibration targets for satellites and telescopes to communication devices and biomedical imaging systems. A main component will be broadband THz absorbers with switchability. However, optically switchable materials in THz are scarce and their modulation is mostly available at narrow bandwidths. Realizing materials with large and broa

THz Spectroscopic Electron Paramagnetic Resonance of the Fe3+Defect in GaN

We present a recently developed method for electron paramagnetic resonance (EPR) measurements in the THz spectral range. The method is based on spectroscopic ellipsometry and thus requires no cavity, unlike conventional EPR. This permits us to scan the frequency parameters in addition to the magnetic field parameters. To showcase this, both frequency and magnetic field scans are performed on Fe-do

Impact of Cardiovascular Neurohormones on Onset of Vasovagal Syncope Induced by Head-up Tilt.

BackgroundVasovagal reflex is the most common form of syncope, but the pathophysiological mechanisms that initiate the reflex are not well understood. We aimed to study supine and early orthostatic levels of the neurohormones involved in control of circulatory homeostasis in relation to the onset of tilt‐induced vasovagal syncope (VVS).Methods and ResultsA total of 827 patients who were investigat

Economic Evaluation of Elective Cesarean Section on Maternal Request Compared With Planned Vaginal Birth—Application to Swedish Setting Using National Registry Data

Objectives: There is a lack of consensus around the definition of delivery by cesarean section (CS) on maternal request, and clinical practice varies across and within countries. Previous economic evaluations have focused on specific populations and selected complications. Our aim was to evaluate the cost-effectiveness of CS on maternal request compared with planned vaginal birth in a Swedish cont

Pulmonary embolism and deep venous thrombosis after COVID-19 : long-term risk in a population-based cohort study

Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), strat

Spectrally Tunable Broadband Gate-All-Around InAsP/InP Quantum Discs-in-Nanowire Array Phototransistors with a High Gain-Bandwidth Product

High-performance broadband photodetectors offering spectral tunability and a high gain-bandwidth product are crucial in many applications. Here, we report on a detailed experimental and theoretical study of three-terminal phototransistors comprised of three million InP nanowires with 20 embedded InAsP quantum discs in each nanowire. A global, transparent ITO gate all around the nanowires facilitat

Joint tenderness at 3 months follow-up better predicts long-term pain than baseline characteristics in early rheumatoid arthritis patients

OBJECTIVE: To investigate pain course over time and to identify baseline and 3-month predictors of unacceptable pain with or without low inflammation in early RA.METHODS: A cohort of 275 patients with early RA, recruited in 2012-2016, was investigated and followed for 2 years. Pain was assessed using a visual analogue scale (VAS; 0-100 mm). Unacceptable pain was defined as VAS pain >40, and low in

A hypothesis - generating Swedish extended national cross-sectional family study of multimorbidity severity and venous thromboembolism

OBJECTIVES: Venous thromboembolism (VTE) is a common worldwide disease. The burden of multimorbidity, that is, two or more chronic diseases, has increased. Whether multimorbidity is associated with VTE risk remains to be studied. Our aim was to determine any association between multimorbidity and VTE and any possible shared familial susceptibility.DESIGN: A nationwide extended cross-sectional hypo

Electronic structure and transport in exotic nanostructures

This thesis explores the physics of nanostructures involving nanowires, quantum dots, superconductors, and topological insulators. These systems serve as excellent platforms for fundamental physics studies and quantum technology applications.The introduction contains information on the band structures of crystalline materials and transport phenomena in quantum dots. It is followed by discussions o

Different Doping Behaviors of Silicon in Zinc Blende and Wurtzite GaAs Nanowires : Implications for Crystal-Phase Device Design

Crystal-phase engineering between zinc blende (ZB) and wurtzite (WZ) structures is becoming an important method in designing unique optoelectronic and electronic semiconductor devices. Doping to engineer their electric properties is thus of critical importance, but a direct experimental comparison in doping these two crystal structures is still missing. Nanowires (NWs) allow the coexistence of bot

Genetics of diabetes-associated microvascular complications

Diabetes is associated with excess morbidity and mortality due to both micro- and macrovascular complications, as well as a range of non-classical comorbidities. Diabetes-associated microvascular complications are those considered most closely related to hyperglycaemia in a causal manner. However, some individuals with hyperglycaemia (even those with severe hyperglycaemia) do not develop microvasc

Telepresence robotic technology support for social connectedness during treatment of children with cancer

Children with cancer experience fragmented school attendance during treatment. Telepresence robots that connect them with school during treatment periods were explored through an intervention involving participant observation followed by semi-structured interviews from 2020–22 with children with cancer, their class teachers, and classmates. We used an abductive approach, inspired by the Agential R