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Purpose: To evaluate the interday repeatability in the measurement of parameters used for the detection of progression of keratoconus by prediction limits (PL) for single measurements, and the repeatability coefficient (RC) for the mean of replicate measurements. Design: Prospective reliability analysis for cases and control eyes. Methods: Twenty-five eyes in 25 subjects with KC and 25 eyes in 25

The enzyme NUDT15 efficiently hydrolyses the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine intolerance, such as leukopenia, and pre-emptive NUDT15 genotyping has been clinically implemented to personalize thiopurine dosing. However, understanding the molecul

This systematic review contributes to the research field of user participation by suggesting a new holistic approach comprising a cyclic process model for long-term participation in the strategic management of urban green spaces, including analysis, design, and implementation phases, each followed by an evaluation. User participation in urban green spaces is encouraged in international conventions

Pharmaceuticals that are not completely metabolized in the human body are excreted in wastewater and may find their way into surface waters, where they can have harmful effects on aquatic fauna and flora. The implementation of ozonation at wastewater treatment plants (WWTPs) can reduce the amount of pharmaceuticals discharged to the environment. Despite the technology readiness level of ozone trea

Digital holography (DH) has been extensively applied in particle field measurements due to its promising ability to simultaneously provide the three-dimensional location and in-plane size of particles. Particle detection methods are crucial in hologram data processing to determine particle size and particle in-focus depth, which directly affect the measurement accuracy and robustness of DH. In thi

Due to its compatible oxygen-transporting abilities, hemoglobin (Hb) is a protein of interest in the development of artificial oxygen therapeutics. Despite continuous formulation attempts, extracellular Hb solution often exhibits undesirable reactions when applied in vivo. Therefore, protein engineering is frequently used to examine alternative ways of controlling the unwanted reactions linked to

In the last 15 years or so, soft selective sweep mechanisms have been catapulted from a curiosity of little evolutionary importance to a ubiquitous mechanism claimed to explain most adaptive evolution and, in some cases, most evolution. This transformation was aided by a series of articles by Daniel Schrider and Andrew Kern. Within this series, a paper entitled “Soft sweeps are the dominant mode o

Nondestructive imaging with both a large field of view and a high spatial resolution is crucial to understand complex materials and processes in science and technology. X-ray ptychography can provide highest spatial resolution but is limited in the field of view by the acquisition time and coherent flux at modern x-ray sources. By multi-beam ptychography, the sample can be imaged in parallel by se

The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development

Modelling capabilities have drastically improved in the last decade. However, in most of the cases the fire response of building elements is predicted by fitting input material properties to the models in order to match test data. This paper presents models developed to predict the unexposed side temperature of stone wool layered composites with stainless steel or gypsum claddings exposed to sever

Functional electrical stimulation (FES) is used for treating foot drop by delivering electrical pulses to the anterior tibialis muscle during the swing phase of gait. This treatment requires that a patient can walk, which is mostly possible in the later phases of rehabilitation. In the early phase of recovery, the therapy conventionally consists of stretching exercises, and less commonly of FES de

Background/Aims Prematurely born infants undergo costly, stressful eye examinations to uncover the small fraction with retinopathy of prematurity (ROP) that needs treatment to prevent blindness. The aim was to develop a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity to safely reduce screening of those infants not needing treatment. DIGIROP-Screen was compared with four

Risk assessments are often performed at multiple system levels in order to inform decision-making; for example, on multiple levels within an organization or on multiple societal levels. One way to conduct risk assessments on the higher system levels is to utilize and aggregate risk information from the lower level assessments. However, the process of aggregating risk information can be highly comp

In 1876, the Kaitakushi, the Japanese government agency responsible for the settlement of the northern island of Hokkaido, hired three Americans from Massachusetts Agricultural College: William Smith Clark, William Wheeler and David Pearce Penhallow. Their task was to establish a comparable institution in Hokkaido, Sapporo Agricultural College, that would spread American-style scientific agricultu

We report the treatment of type Ib endoleak after fenestrated endovascular aneurysm repair (FEVAR) with iliac branch device (IBD) to allow exclusive transfemoral access without a femoral-to-femoral through-and-through wire. The patient was treated with fenestrated endovascular aneurysm repair and showed expansion of the aneurysm owing to a type Ib endoleak. An IBD was implanted by the use of a con

The efficiency of irrigation, as well as optimization of nutrients, affect spinach yield in all growth stages. In this study, the sensitivity of spinach (early and mature yields) to shallow saline groundwater and the effect of fertigation treatments on mature yield were experimentally investigated. The sprinkler irrigation experiments were conducted on 0.47 ha of silty clay soil at the University

Recent studies indicate a crucial role for neuronal glycogen storage and degradation in memory formation. We have previously identified alpha-amylase (α-amylase), a glycogen degradation enzyme, located within synaptic-like structures in CA1 pyramidal neurons and shown that individuals with a high copy number variation of α-amylase perform better on the episodic memory test. We reported that neuron

Background & Aims: In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify