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Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha
Background: Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. This retrospective study evaluated its association with 30-day survival after out-of-hospital cardiac arrest (OHCA) in a Swedish community from 2003 to 2015. Methods: Out of 3680 patients with OHCA, 1100 were hospitalized after return of spontaneous circulation an
The post-2015 developmental agenda and the SDGs have been formulated to advance holistic global progress and enable the adoption of quantitative targets for all countries by recognizing their respective national realities and capacities. This research examines how global ambitions can guide national policy formulation by selecting the Italian Republic and the People's Republic of Bangladesh as mod
Medellivslängden ökar och är idag över 80 år i 34 av världens länder, jämfört med i 19 länder år 2005. Detta ärpositivt, men den åldrande befolkningens hälsa är också en samhällsutmaning inte minst för välfärdssystemen.Hälso- och sjukvården riskerar blir särskilt belastad med allt fler vårdsökande äldre. Yrkesgrupperna inom hälsoochsjukvården har dessutom en hög medelålder och är samtidigt bland d
The aim of this study was to examine support given to adult female victims of human trafficking for sexual purposes, by interviewing Swedish professionals within the organisation field. The focus was on how the support given in Sweden is adjusted to meet the women’s needs according to the professionals. We also examined the follow-up within other countries and their collaboration with Swedish orga
The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essenti
Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Afri
Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life
Background: Breathlessness on exertion is a common, distressing, and limiting symptom that can be quantified on incremental cardiopulmonary exercise testing (CPET) using normative reference equations. Research Question: Is the breathlessness abnormality best uncovered and assessed at symptom limitation (peak exercise) compared with submaximal exercise intensities? Study Design and Methods: This wa
After several years of broad support for the European Green Deal (EGD), a significant number of communities and politicians are calling on the EU and Member States to slow down its green measures and focus on ‘other’ crises, most notably the cost-of-living crisis.This White Paper argues that environmental, social and economic crises can’t be looked at in isolation. And that addressing today’s ‘pol
SACO-rådet i Umeå kommun 2022-03-03 KALLELSE TILL SACORÅDETS ÅRSMÖTE 2022 Tid: Tisdagen den 29 mars, kl. 17.00 Plats: Teams Program: Årsmöte Anmälan: Senast 2022-03-28 till Karin Berggren, karin.berggren@umea.se. Sacorådets uppgifter är bland annat att handlägga de frågor som enskilt förbund delegerar och att vara förbundens kontaktorgan i frågor som är av gemensamt och övergripande intresse. Råde
This paper presents a model for corporate social responsibility (CSR) created to integrate human rights issues in sustainable tourism, through public-private partnerships between the industry, non-governmental organisations (NGOs)and international governmental organisations (IGOs). The experience with the model in practice is described in a case study presenting a voluntary code of conduct adopted
Together with response time the force of responses to stimuli can provide important clues about cognitive and affective processes. However, while there has been much discussion of factors involved in the accurate measurement of response time (RT), key issues and assumptions in assessment of response force (RF) have been far less studied. Here, hierarchical Bayesian analysis is used to examine the
The purpose of this paper is to examine how behavioural biases affect consumers’ response to energy-use information provided through smart meters (SM). We take insights from behavioural economics and carry out two real-life experiments with SMs and electricity users. The experiments were conducted in Copenhagen (Denmark) to identify and assess the potential of two economic behavioural biases, sali
To ensure energy to meet needs for economic growth and sustainable development more emphasis should be given to energy efficiency, renewable energy and new technologies for both energy end-use and supply. One key technology is gasification of coal to produce liquid and gaseous fuels, and electricity. The overall conclusion is that there are plausible energy-technology strategies, well within reach
Vid tiden för Göteborgs 400-årsjubileum var ordet trygghet på många av göteborgarnas läppar. Göteborgs Stad hade sedan några år inlett ett tydligt fokus på att försöka öka invånarnas trygghet genom projekt som ”Trygg i Göteborg” och genom polisiära insatser för att minska den organiserade brottsligheten. Med tanke på sådana insatser tedde det sig kanske inte underligt att hela 15 procent av de sva
We report the use of multinodal acoustic trapping for high throughput and high capacity capturing of EV's (extracellular vesicles) for quantitative mass spectrometry analysis. The multinode trapping unit was shown to isolate sufficient amount of EV's from dilute biological samples (urine and cell culture supernatant) at flow rates of 500 ul/min within minutes, enabling EV proteome profiling. This
