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Knowledge of infective endocarditis (IE) caused by Streptococcus dysgalactiae (SD) is limited. This study aimed to identify the clinical and microbiological features of SD-caused IE and to investigate any possible synergy between penicillin and gentamicin on SD isolates. Cases of IE 2008–2016 due to SD reported to the Swedish Registry of Infective Endocarditis (SRIE) were identified. Isolates were
The human host defense peptide LL-37 possesses antimicrobial activity but also affects host cell function and viability. Mast cells are involved in innate immunity but no data have been presented on effects of LL-37 on human mast cell viability and export of nucleic acids. Here, we demonstrated by immunofluorescence microscopy that synthesized LL-37 was internalized by human LAD2 mast cells and de
Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.
OBJECTIVE: We have evaluated a new technique of cardiac de-airing that is aimed at a) minimizing air from entering into the pulmonary veins by opening both pleurae and allowing lungs to collapse and b) flushing out residual air from the lungs by staged cardiac filling and lung ventilation. These air emboli are usually trapped in the pulmonary veins and may lead to ventricular dysfunction, life-thr
Popular Abstract in Swedish Avhandlingen utreder några av konsekvenserna av de institutionella reformer som genomfördes i Sydafrika under 1990-talet, med särskilt fokus på det nya kommunsystemet, enligt vilket varje kommun är skyldig att stimulera lokal ekonomisk utveckling i samarbete med det lokal näringslivet och andra civilsamhälleliga aktörer. Den syftar även till att utveckla den samhällsvetThis thesis focuses on the consequences of the institutional transformations in South Africa during the 1990s with specific reference to the introduction of a mode of local governance based on the direct participation of private and civic actors in policymaking and implementation. The study also aims to contribute to theory. The approach is that public, private and civic associations are best unde
Land subsidence, a silent death, occurs due to various factors like significant reduction in groundwater (GW) levels. It is a widespread phenomenon with irreparable consequences on buildings, infrastructures, and, in severe cases, groundwater aquifers. This study aims to assess the impact of river flow on the acceleration and control of land subsidence in an arid and semi-arid region. To achieve t
Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas (LUAD) and exerts tumor-promoting effects. Here, we explored miRNA profiles in ASCL1-positive LUADs and identified several miRNAs closely associated with ASCL1 expression, including miR-375, miR-95–3p/m
Infectious diseases in farm animals triggered by pathogenic microorganisms affect the health and well-being of livestock and human populations. Pathogen detection is an important step for the successful diagnosis, treatment and control of infectious diseases in animals. Pathogens that persist in the poultry and livestock industries can be responsible for more than 70% of emerging infections. Thus,
Background: Involving librarians as team members can lead to better quality in reviews. To improve their search results, an international diabetes project involved two medical librarians in a large-scale project planning of a series of systematic reviews for clinical guidelines in diabetes precision medicine. Case Presentation: The precision diabetes project was divided into teams. Four diabetes m
Background: Affectivity has been suggested as a complex adaptive meta-system composed of positive affect and negative affect, two independent but interrelated markers of well-being, that can be represented as four distinct affective profiles: self-fulfilling (high positive affect/low negative affect), high affective (high positive affect/high negative affect), low affective (low positive affect/lo
CONTEXT: When clinically stable, patients with A-β+ Ketosis-Prone Diabetes (KPD) manifest unique markers of amino acid metabolism. Biomarkers differentiating KPD from type 1 (T1D) and type 2 diabetes (T2D) during hyperglycemic crises would accelerate diagnosis and management.OBJECTIVE: Compare serum metabolomics of KPD, T1D and T2D patients during hyperglycemic crises, and utilize Classification a
This Massive Open Online Course (MOOC), offered in partnership with online learning provider Coursera, is a free resource for university students who are currently involved in writing assignments or degree projects as well as for students who wish to learn about academic writing in order to prepare for future writing tasks at university. Although the course provides guidance to all student writers
Somatic hypermutation and isotype switch recombination occur in germinal center B cells, are linked to transcription, and are similarly affected by deficiency in MutS homologue (MSH)2. Class-switch recombination is abrogated by disruption of genes encoding components of the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs))/Ku complex and likely involves nonhomologous end joining (NHEJ
To compare clinical outcomes 5 years after carpal tunnel release among patients with and without diabetes.
We report experimental oscillator strengths for 88 Ti I transitions covering the wavelength range 465-3892 nm, 67 of which had no previous experimental values. Radiative lifetimes for 13 energy levels, including the low energy levels 3d(2)(F-3) 4s4p ((3)p) z(5)D(j)degrees have been measured using time-resolved laser-induced fluorescence. Intensity-calibrated Ti I spectra have been measured using F
Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue sample
