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Background: Severe hereditary alpha-1-antitrypsin deficiency (AATD) is a known risk factor for the early development of pulmonary emphysema and COPD, especially in smo-kers. By the Swedish national screening programme carried out from 1972 to 1974, a cohort of individuals with severe (PiZZ) AATD was identified and has been followed up regularly. The aim of this study was to investigate health stat
Under the Paris Agreement, parties should undertake a global stocktake of progress toward meeting the goals of the agreement and tackling climate change. The first global stocktake will be undertaken in 2023, and an assessment of loss and damage from climate change is an important part of the process. Loss and damage refer to the impacts of climate change felt when mitigation and adaptation effort
The asymmetry of the cross section of the 12C(γ; p0)11B and 12C(γ; p1)11B reactions has been measured in the energy range 40...55MeV using linearly polarized tagged photons of the MAX-lab facility. The asymmetry of the process 12C(γ; p0)11B is Σ ∼ 0:85, that implies one-particle reaction mechanism. The asymmetry of the reaction 12C(γ; p1)11B is smaller, Σ ∼ 0.6...0.7, that may be due to the stron
After successful demonstrations of soft-tissue phase-contrast imaging with grating interferometers at synchrotron radiation sources and at laboratory based x-ray tubes, a first preclinical CT scanner with grating based phase contrast imaging modality has been constructed. The rotating gantry is equipped with a three-grating interferometer, a 50 watt tungsten anode source and a Hamamatsu flat panel
Introduction How the burden of disease varies during different phases after floods and after storms is essential in order to guide a medical response, but it has not been well-described. The objective of this review was to elucidate the health problems following flood and storm disasters.Methods: A literature search of the databases Medline (US National Library of Medicine, National Institutes of
Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized therapeutic options. We studied the translational significance of liquid biopsy in a uniformly treated trial cohort. Pretreatment circulating tumor DNA (ctDNA) revealed hidden clinical and biological heterogeneity,
We present optical properties in the near-infrared to vacuum-ultraviolet spectral range of hexagonal YMnO3. The high-quality (110)-oriented bulk single crystal was grown by the optical floating zone technique. We have determined the tensor of the dielectric function by means of Mueller matrix ellipsometry in the wide spectral range (0.5-9.15) eV. For the spectral range below 5.4 eV, we present muc
Seven new genera, i.e. Brianiopsis for the former ‘Lambiella’ impavida group, Farkasiella for the former ‘Trapeliopsis’ aeneofusca group, Gallowayiopsis for the former ‘Trapelia’ collaris group, Kleopowiella for the former ‘Trapelia’ placodioides group, Trapegintarasia for the former ‘Trapelia’ lilacea group, Trapejamesia for the former ‘Trapelia’ corticola branch, as well as Xyloelixia for the fo
Groundwater is a crucial source of water supply in drought conditions, and an auxiliary water source in wet seasons. Due to its increasing importance in view of climate change, predicting groundwater level (GWL) needs to be improved to enhance management. We used adaptive neuro-fuzzy inference systems (ANFIS) to predict the GWL of the Urmia aquifer in northwestern Iran under various input scenario
Light microscopy has been a favorite tool of biological studies for almost a century, recently producing detailed images with exquisite molecular specificity achieving spatial resolution at nanoscale. However, light microscopy is insufficient to provide chemical information as a standalone technique. An increasing amount of evidence demonstrates that optical photothermal infrared microspectroscopy
Habitat preferences and foraging strategies affect population-level space use and are therefore crucial to understanding population change and implementing spatial conservation and management actions. We investigated the breeding season habitat preference and foraging site fidelity of the under-studied and threatened, Baltic Sea population of Caspian Terns (Hydroprogne caspia). Using GPS devices,
This thesis ponders the participation of municipal authorities amidst processes of sociolegal change. Such interest originated from acknowledging the limited autonomy that municipalities have in the nested scalar jurisdictional order of most contemporary states, the relevance of municipalities as spaces of local democracy, the social movements’ advocacy for social change at local levels, and the i
Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their physiological functions. Here, we show that Lrig-null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis and bone morphogenetic protein (B
Research suggests that until recently families in history could only avoid episodes of poverty if they put money aside. By helping to smooth consumption over the family life cycle, finance could prevent impoverishment, and is also likely to have had an effect on family life. Saving may have influenced cohabitation structures and the timing and incidence of birth, marriage, and death. That families
BackgroundStudies focusing on dietary pesticides in population-based samples are scarce and little is known about potential mixture effects. We aimed to assess associations between dietary pesticide exposure profiles and Type 2 Diabetes (T2D) among NutriNet-Santé cohort participants.MethodsParticipants completed a Food Frequency Questionnaire at baseline, assessing conventional and organic food co
Purpose: Radionuclide therapy with 177Lu-DOTATATE is well established for patients with advanced somatostatin receptor–positive neuroendocrine tumors with a standard schedule of 7.4 GBq at four occasions. However, this approach does not consider individual variability affecting the tumor radiation dose or dose to organs at risk. Therefore, it is important to assess more personalized strategies. Th
The data generated in our digital society can be harnessed to generate policy-relevant indicators on waste prevention and reuse, and be used to fill in the gaps left by official data and statistics. This project elaborates where the greatest potentials lie for improving the monitoring of waste prevention and reuse, and presents a roadmap for improving the monitoring of waste prevention in the Nord
