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The objective of this study was to examine the association of the intensity of treatment, ranging from high-dose intensive factor VIII (FVIII) treatment to prophylactic treatment, with the inhibitor incidence among previously untreated patients with severe hemophilia A. This cohort study aimed to include consecutive patients with a FVIII activity <0.01 IU/mL, born between 2000 and 2010, and observ

We consider a class of pseudodifferential evolution equations of the form u(t) + (n(u) + Lu)(x) = 0, in which L is a linear smoothing operator and n is at least quadratic near the origin; this class includes in particular the Whitham equation. A family of solitary-wave solutions is found using a constrained minimization principle and concentration-compactness methods for noncoercive functionals. T

The prototypical antimicrobial peptide, melittin, is well-known for its ability to induce pores in zwitterionic model lipid membranes. However, the mechanism by which melittin accomplishes this is not fully understood. We have conducted all-atom and coarse-grained molecular dynamics simulations which suggest that melittin employs a highly cooperative mechanism for the induction of both small and l

As the physical consequences of accidental falls in the elderly are well-researched, the long-term associations between falls and quality of life and related concepts are less known. The aim of this study was to prospectively examine the long-term relations between falls and health-related quality of life (HRQoL) and life satisfaction (LS) over six years in the general elderly population. One thou

We have evaluated the consequences of work organization on musculoskeletal health. Using a postal questionnaire, answered by 1600 female grocery store workers, their main work tasks were identified and four work groups were defined (cashier, picking, and delicatessen work, and a mixed group, who performed a mix of these tasks). The crude odds ratios (ORs) for neck/shoulder complaints were 1.5 (95%

Appropriate regulation of hematopoietic stem cell (HSC) numbers and function is a requisite for life-long blood cell replenishment. Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs. In the literature, we noted inconsistencies in how serial transpl

P>1. Female preferences for particular male ornaments may shift between populations as a consequence of ecological differences that change the reliability and detectability of the ornament, but few studies have examined how ornaments function in different populations. 2. We examined the signalling function of male plumage ornaments in a warbler, the common yellowthroat (Geothlypis trichas), breedi

In Japan, rising costs have impacted the framework of maintaining an efficient and effective healthcare system. Today, urgent implementation of programs to address this need have led to a rebuilding of the entire approach of medical evaluation and clinical care. Recent developments in clinical proteomics based on mass spectrometry (MS) for identifying, sequencing, and quantifying disease-relevant

The functional separation of risk assessment and risk management has long been at the heart of risk analysis structures. Equally long it has been criticized for creating technocratic risk management due to valuations being done in the risk assessment to which the stakeholders do not have access. The criticism has mostly been of an ethical nature. Arguably, in separating risk assessment and risk ma

Next-generation sequencing technologies are making it possible to study the role of rare variants in human disease. Many studies balance statistical power with cost-effectiveness by (a) sampling from phenotypic extremes and (b) utilizing a two-stage design. Two-stage designs include a broad-based discovery phase and selection of a subset of potential causal genes/variants to be further examined in

Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cogniti

Removal of five acidic pharmaceuticals (ibuprofen, ketoprofen, naproxen, diclofenac and clofibric acid) by activated sludge from five municipal activated sludge treatment processes, with various sludge ages and nitrification capacities, was assessed through batch experiments. The increase in aerobic sludge age from 1-3 to 7 d seemed to be critical for the removal of naproxen and ketoprofen, with m

Background: Titanium zirconium alloy with 1317% zirconium (TiZr1317) shows significantly better mechanical attributes than pure Ti with respect to elongation and fatigue strength. This material may be suitable for thin implants and implant components exposed to high mechanical constraints. Purpose: The aim of this study was to test the hypothesis that TiZr1317 and Ti implants show comparable osseo

The moisture content of wood is commonly determined by measuring the electrical resistance between two electrodes inserted in the wood. However, problems using this method close to wood surfaces were reported in a previous study. In the present study, the effect of the distance to a surface and the specimen size on the measured electrical resistance was studied analytically as follows. The two ele

Background: Low socioeconomic position (SEP) in adulthood has been associated with overweight and obesity in high-income countries. However, little is known about the contribution of childhood SEP to weight change. Using a Swedish general population sample, this study aimed to examine the association between five-year weight gain among adults and socioeconomic position in childhood and adulthood.

Dilute solutions of -lactoglobulin (-Lg) A, B, and C were heated in phosphate buffer at temperatures between 40 and 94 C for 10 min, cooled, and analyzed using near-UV and far-UV circular dichroism (CD). The decrease in near-UV CD intensity at 293 nm (293) could be analyzed in terms of a two-state model, and the stability was -Lg C > -Lg A > -Lg B on the basis of the midpoint temperatures for samp

The influence of salt, temperature, and deuterium oxide on the self-aggregation of n-nonyl-beta-D-glucoside (beta-C(9)G(1)) in dilute solution has been investigated by static and dynamic light scattering, neutron scattering, and tensiometry. Scattering data show that the micelles can be described as relatively stiff, elongated structures with a circular cross section. With a decrease of temperatur

The direct effects of CO2 level changes on plant water availability are usually ignored in plant habitat models. We compare traditional proxies for water availability with changes in soil water (fAWC) predicted by a process-based ecosystem model, which simulates changes in vegetation structure and functioning, including CO2 physiological effects. We modelled current and future habitats of 108 Euro