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When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the im

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un

Objective: The association between mammographic density (MD) and breast cancer (BC) recurrence and survival remains unclear. Patients receiving neoadjuvant chemotherapy (NACT) are in a vulnerable situation with the tumor within the breast during treatment. This study evaluated the association between MD and recurrence/survival in BC patients treated with NACT. Methods: Patients with BC treated wit

Using the newly described streptococcal surface protein, protein G, which has powerful immunoglobulin G binding properties, solid-phase radioimmunoassays were developed for the quantitation of goat and rat immunoglobulin G bound to the plastic surface of microtiter plates. The binding of goat immunoglobulin G to the surface via a specific antigen (guinea pig alpha 1-microglobulin) permitted the de

Background: The main purpose for measuring urinary free sialic acid (FSA) is to diagnose sialic acid (SA) storage diseases. Elevated amounts of conjugated sialic acid (CSA) are observed in several diseases indicating the need to quantify CSA as well. A LC-MS/MS method for quantification of FSA and total sialic acid (TSA) in urine is developed and validated. Methods: FSA is analyzed directly after

CONTEXT: Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy has demonstrated an improved metabolic profile compared to conventional 3-times-daily (TID-HC) therapy among patients with primary adrenal insufficiency. This effect might be related to a more physiological cortisol profile, but also to a modified pattern of cortisol metabolism. OBJECTIVE: This work aimed to study cor

PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti

Periodic structures are known to produce passbands and stopbands for propagation of vibration energy within the frequency domain. Sources vibrating harmonically at a frequency within a passband can lead to propagation of energy through propagating modes over long distances. However, sources vibrating at a frequency within a stopband excite only nearfields in the form of attenuating and evanescent

We analyze the convergence rate of the Dirichlet-Neumann iteration for the fully discretized one dimensional unsteady transmission problem. Specifically, we consider the coupling of two linear heat equations on two identical non overlapping intervals. The Laplacian is discretized using finite differences on one interval and finite elements on the other and the implicit Euler method is used for the

The patient is the centre of a web of relationships, and the impact of his/her disease on family members and caregivers must be taken into account. The aim of this study was to identify the specific instruments that measure the impact of a dermatological disease on the quality of life (QoL) of family members, by performing a systematic search of the literature. Fifteen papers were identified, desc

There is a class of oligodendrocyte progenitors, called O-2A progenitors, that is characterized by expression of platelet-derived growth factor &agr;-receptors (PDGFR(&agr;)). It is not known whether all oligodendrocytes are derived from these PDGFRalpha-progenitors or whether a subset(s) of oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s). We investigated the re

Purpose: The study aims to advance the understanding of collaborative consumption through the research on the engagement rules, conventions, and norms that govern the practice. The study postulates that it is through the possession of the right competences and meaning that permit insiders to successfully apply the rules of collaborative consumption while deterring outsiders from making an initial

Ett patent är en immateriell rättighet som medför en ensamrätt för patenthavaren att dra affärsmässig nytta av en viss uppfinning under en begränsad tidsperiod. Den som kränker patenthavarens ensamrätt gör sig skyldig till patentintrång. Vid patentintrång tillhandahåller den svenska patentlagen (1967:837) ett antal olika sanktionsmöjligheter. De primära civilrättsliga sanktionsformerna utgörs av pA patent is a kind of intellectual property right that grants the patent holder an exclusive right to profit from a certain invention for a limited time period. Anyone who violates the patent holder's exclusive right is guilty of patent infringement. In cases of patent infringement the Swedish Patent Act (patentlag 1967: 837) provides a number of different sanction options. The primary civil s

This project explores how a beginner friendly music production device can lower the threshold for engaging with sound creation and rhythm making. Many existing tools rely on prior knowledge or technical skill, which discourages new users from experimenting in creative ways. This project instead focuses on quick feedback, clear interaction and a tactile experience that invites curiosity and play. T

De flesta av oss associerar nog kemikalier med något negativt, men sanningen är att kemikalier utgör en förutsättning för mycket av den välfärd som vi ser idag. Tvärtemot vad man kan tro, så är det inte bara i produkter som plast, färg, lösningsmedel, med mera som dessa förekommer, utan även i produkter som räddar liv, till exempel i utrustning inom sjukvården och för vattenrening. Därför är de meThe production and use of chemicals has grown exponentially over the past 50 years. Although the knowledge of hazards and risks associated with chemicals towards humans and the environment has increased, we know frightenedly little about how dangerous these might become when part of finished products. Companies now need to be more concerned about which chemicals exist in their products. For the co

The thesis circles around Social Media, B2B Brand Building and Business Performance Measurements. In the intersection between these a knowledge gap was identified. The following research questions were formed: How should companies go about when implementing Social Media? How should the performance of Social Media engagement be measured? The urgency for answering these questions was identified. Th

COSM23 Contemporary Chinese Society Literature List Spring Semester 2026 Approved on 18 November 2026 by the education board at the Centre for East and South-East Asian Studies. Introduction In 2026, COSM23 will require students to read 438 pages of book chapters and approximately 1038 pages of journal articles, policy documents, and expert popular discourse. In addition, student will select about

https://www.ht.lu.se/media/utbildning/dokument/kurser/COSM23/20261/COSM23_2026_literature_list.docx - 2026-05-21

The social and linguistic construction of time in an Amazonian culture To appear in Luna Filipovič and Kasia M. Jaszczolt (eds.) Space and Time in Languages and Cultures II: Language, Culture, and Cognition. Human Cognitive Processing 37. Amsterdam: John Benjamins. 1 Event-based time intervals in an Amazonian culture. * Vera da Silva Sinha (Federal University of Rondônia) Chris Sinha (Lund Univers

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/SilvaSinha-etal-reprint.pdf - 2026-05-28

3 Roles and Reasons 7 Vocabularies of Reason 2025 Pufendorf Lectures Lund University Lecture III Roles and Reasons I. Introduction The main aim of my first two lectures was to put on the table the concept of reason relations of implication and incompatibility, and to show how that topic appears from the points of view afforded by different ways of talking about it. From the vantage point of bilate

https://www.fil.lu.se/fileadmin/user_upload/pufendorf/Files/Lecture_3.pdf - 2026-05-28