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Large regional variation in endovascular thrombectomy rates for acute ischemic stroke in Sweden

INTRODUCTION: Endovascular thrombectomy (EVT) is a significant improvement in the care of acute ischemic stroke (AIS) patients, but only a small portion of patients receive treatment. Our aim was to analyze EVT implementation in Sweden according to a set of key performance indicators (KPIs) for procedural and implementational effectiveness. METHODS: A nationwide prospective registry-based observ

Auto machine learning for predicting ship fuel consumption

In recent years, machine learning has evolved in a fast pace as both algorithms and computing power are constantly improving. In this study, a machine learning model for predicting the fuel oil consumption from engine data has been developed for a cruise ship operating in the Baltic Sea. The cruise ship is equipped with legacy volume flow meters and newly installed mass flow meters, as well as an

Pathophysiology and management of sensitive skin : position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)

The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of

EuRoSDR GeoBIM project a study in Europe on how to use the potentials of BIM and GEO data in practice

In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the qu

Not All Tumors Are Alike : Varying Efficacy of FLASH Across Tumor Types and Oxygenation Status in Spheroid Models

OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams

Changes in Intestinal Permeability Ex Vivo and Immune Cell Activation by Three Commonly Used Emulsifiers

Food additives such as emulsifiers are used in increasing quantities in the food industry. The aim of this study was to compare three different emulsifiers (polysorbate 80 (P80), carboxymethyl cellulose (CMC), and β-lactoglobulin (β-lac) with regards to their effect on the stimulation of immune cells and intestinal permeability. The immune stimulatory effects were studied in the myeloid cell line

Autoimmune markers in lymphoid malignancies.

Chronic immune stimulation such as Helicobacter pylori (hp) infection, Sjögren's syndrome or coeliac disease may initiate non-Hodgkin lymphoma (NHL). The opposite (appearance of autoimmunity) has also been reported. The aim of this study was to describe the pattern of these immune markers in patients with lymphoid malignancies. Sera from 96 patients with NHL (median age 72, range 38-88, F/M 41/55)

Using Dental Register Information and Questionnaire Data to Assess Periodontitis in Large Cohort Studies

Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionna

Site- and Energy-Selective Low-Energy Electron Emission by X-rays in the Aqueous Phase

Low-energy-electron emission from resonant Auger final states via intermolecular Coulombic decay (RA-ICD) has previously been described as a promising scenario for controlling radiation damage for medical purposes, but it has so far only been observed in prototypical atomic and molecular van der Waals dimers and clusters. Here, we report the experimental observation of RA-ICD in an aqueous solutio

The World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology : Part 1 – Lymph Node

Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of

Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)—An initial pilot-study of a randomized clinical trial

Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coro

Variable radiological lung nodule evaluation leads to divergent management recommendations

Radiological evaluation of incidentally detected lung nodules on computed tomography (CT) influences management. We assessed international radiological variation in 1) pulmonary nodule characterisation; 2) hypothetical guideline-derived management; and 3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: 1) first-choice composi

Development of improved PLIF CH detection using an Alexandrite laser for single-shot investigation of turbulent and lean flames

We report on the development of planar laser-induced fluorescence (PLIF) for CH imaging with improved detection sensitivity for single-shot investigations of turbulent, lean, premixed flames. A ringcavity, pulsed Alexandrite laser was frequency-doubled to excite the lines in the R-branch band-head of the B-X (0,0) band and broadband fluorescence from the B-X (0,1), A-X (1,1) and (0,0) bands, overl

Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function

Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mec

Analysis of wind-induced vibrations in high-rise buildings

Buildings are getting taller due to increased urbanisation and densification of cities. More advanced construction methods and the desire to construct impressive buildings is also supporting the trend. Due to their inherent slenderness resulting in low eigenfrequencies, these buildings are susceptible to wind-induced vibrations which can be highly disturbing for occupants. Already barely perceivab