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Oesophageal fluoroscopy is a radiological procedure that uses dynamic recording of the swallowing process to evaluate morphology and function simultaneously, a characteristic not found in other clinical tests. It enables a comprehensive evaluation of the entire upper gastrointestinal tract, from the oropharynx to oesophagogastric bolus transport. The number of fluoroscopies of the oesophagus and t
This chapter examines the development of maternal and infant mortality and its connection to changes in medical and healthcare treatment of mothers and infants in the city of Landskrona, Sweden, and its rural hinterland between 1905 and 2015. The authors show that maternal mortality, stillbirth rates, and infant mortality declined strongly in this period. In parallel, hospitals began to admit more
Beliefs about the moral status of children have changed significantly in recent decades in the Western world. At the same time, knowledge about likely consequences for children of individual, parental, and societal choices has grown, as has the array of choices that (prospective) parents may have at their disposal. The intersection between these beliefs, this new knowledge, and these new choices h
The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized
Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle
Evaluating soil strength by geophysical methods using P-waves was undertaken in this study to assess the effects of changed binder ratios on stabilization and compression characteristics. The materials included dredged sediments collected in the seabed of Timrå region, north Sweden. The Portland cement (Basement CEM II/A-V, SS EN 197-1) and ground granulated blast furnace slag (GGBFS) were used as
Advanced instrumentation and versatile setups are needed for understanding light interaction with biological targets. Such instruments include (1) microscopes and 3D scanners for detailed spatial analysis, (2) spectral instruments for deducing molecular composition, (3) polarimeters for assessing structural properties, and (4) goniometers probing the scattering phase function of, e.g., tissue slab
Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid
Acoustic discrimination of speech sounds is affected by various factors, ranging from more universal acoustic properties of categories to the phoneme systems of the native language and dialect, and even influences from languages learned later in life. A discrimination experiment containing East Central Swedish vowels was carried out with 30 native Swedish listeners in order to explore the variatio
The Bible appears regularly in Margaret Atwood’s novels, from The Edible Woman in 1969 to The Testaments in 2019. Atwood’s characters do not tend to be religious, but like most people in the Western world, they encounter the Bible in schools, at funerals, in headlines, advertisements, and occasionally from religious people themselves. Atwood’s Bible is a Christian Bible, the references running fro
INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and cardiac sarcoidosis (CS) can show significant overlap in their clinical presentation. Differentiation between both is crucial for optimal patient management. Aim of this study is to develop an ECG-based machine learning model to distinguish between ARCV and CS patients. The study population included 100 patients (50 with ARCV and 50 with C
Vad återstår i dag av de platser som arbetar rörelsenskapade åt sig själv, och som utnämndes till platserför folket? Vilka spår kan vi se av dessa i landskapet?Vilka berättelser om och minnen från sådana platserlever ännu kvar?
BACKGROUND: Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been
High-throughput omics data often contain systematic biases introduced during various steps of sample processing and data generation. As the source of these biases is usually unknown, it is difficult to select an optimal normalization method for a given data set. To facilitate this process, we introduce the open-source tool "Normalyzer". It normalizes the data with 12 different normalization method
In the recently completed and formally ratified new series and stage classification of the Ordovician System, the base of the Middle Ordovician Series coincides with the base of the global Dapingian Stage. In the Global Stratotype Section and Point (GSSP) of this stage, which is located at Huanghuachang in southern China, the base of the Dapingian Stage is defined its the level of first appearance
Complex traits, including inflammatory rheumatic diseases, have important genetic features, but most of the responsible genes have not been conclusively identified. Genetic analysis of inbred animal models and comparative genetics - the comparison of genes between different species - might help to identify the crucial genes and to investigate more directly the biology involved. Genome-wide linkage
