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In polygynous species with biparental care, mates are often acquired in succession. Most research has focussed on the cost of polygyny in secondary females, but primary females may also suffer from reduced paternal care. The likelihood of sharing a male may be higher for early laying females, which could counteract the fitness benefits of breeding early. In this study, we use 12 years of data on p
Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. The pancreatic beta-cell is controlled by ion channels. Voltage-gated
Geoengineering is the deliberate and large-scale intervention in the Earth's climate system in an attempt to mitigate the adverse effects of global warming. Now that climate emergency is upon us, claims that geoengineering is inevitable are rapidly proliferating. How did we get into this situation where the most extreme path now seems a plausible development? Is it an accurate representation of wh
In both Stockholm and Tokyo, small dwell time delays of at most 5 min make up around 90% of the total delays for commuter trains. To understand these disturbances, we use high resolution data on dwell times and passenger counts from both countries over the last several years. We find that trains in Tokyo are much more congested than in Stockholm, and that the exchange of passengers is modest at mo
Potassium and chlorine chemistry at high temperature is of great importance in biomass utilization through thermal conversion. In well-defined hot environments, we performed quantitative measurements of main potassium species, i.e., potassium hydroxide (KOH), potassium chloride (KCl) and K atoms, and the important radical OH. The concentrations of KOH, KCl and OH radicals were measured through a n
Over the past two decades, there has been a sharp rise in the use of prescription opioids. In several countries, most notably the United States, opioid-related harm has been deemed a public health crisis. As surgeons are among the most prolific prescribers of opioids, growing attention is now being paid to the role that opioids play in surgical care. While opioids may sometimes be necessary to pro
Structured laser illumination planar imaging (SLIPI)-based techniques have been employed during the past decade for addressing multiple light scattering issues in spray imaging. In this article, SLIPI droplet sizing based on the intensity ratio of laser-induced fluorescence (LIF) over Mie scattering (SLIPI-LIF/Mie) and SLIPI-Scan for extinction-coefficient (μe) mapping are applied simultaneously.
Based on the comparative analysis of the experimental values determined for the tribological parameters for the three novel nano-porous composition base and two conventional brake lining materials while friction with the grey cast iron disc, it was shown the considerable high tribological efficiency of the novel nano-porous composition base lining materials in comparison with the conventional (fro
Hans Henrik Lidgard & Sverker Jönsson enligt delegation Abstract: Anbudssamverkan, kvoteringsöverenskommelser, priskarteller och marknadsuppdelnings-åtgärder förekommer som separata överträdelser av konkurrensrätten. Dessa konkurrensrättens kärnöverenskommelser förefaller i allt att uppfylla kriterierna för allvarliga förmögenhetsbrott. Förfarandena kan fogas in under strafflagstiftningens bed
This study examines the interactions between correctional officers and prisoners during transport between prisons, from the staff’s perspective, based on a thematic analysis of 14 interviews with transport officers in Sweden. The three central themes in their stories regarding their work – namely, disciplinary discretion, interaction and compassion – were analysed by following the process of picki
State-structured populations are ubiquitous in biology, from the age-structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco-evolutionary dynamics is critical not only for fundamental understanding but also for conservation and treatment purposes. Although some methods have been developed in the literature for modelling eco-evoluti
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for C
This article addresses the role of the corporate purpose in strategic financial communication from the perspective of investor relations officers (IROs) with particular reference to their sensemaking process. Strategic financial communication increasingly includes intangible assets that contribute to the value of the company. At the same time, more and more companies are publishing corporate purpo
Background AU Self-reported: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly adherence to the Mediterranean diet has been: modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured
High-throughput imaging allows in vitro assessment of neuron morphology for screening populations under developmental, homeostatic, and/or disease conditions. Here, we present a protocol to differentiate cryopreserved human cortical neuronal progenitors into mature cortical neurons for high-throughput imaging analysis. We describe the use of a notch signaling inhibitor to generate homogeneous neur
We present MultiPsi, an open-source MCSCF program for the calculation of ground and excited states properties of strongly correlated systems. The program currently implements a general MCSCF code with excited states available using either state-averaging or linear response. It is written in a highly modular fashion using Python/C++ which makes it well suited as a development platform, enabling eas
The ideal timing to implement anterior cruciate ligament injury prevention programs with respect to maturation is unclear. The purpose of this study was to investigate the effects of an injury prevention program on knee mechanics in early-, late-, and post-pubertal females. In the study, 178 adolescent female basketball players were assigned to six groups: early-pubertal training, early-pubertal c
A novel dual-amplification system based on CRISPR-Cas12a and horseradish peroxidase (HRP) was developed for colorimetric determination of MC-LR. This dual-amplification was accomplished by combining the nuclease activity of CRISPR-Cas12a with the redox activity of HRP. HRP linked to magnetic beads through an ssDNA (MB-ssDNA-HRP) was used to induce a color change of the 3,3′,5,5′-tetramethylbenzidi
The oxygen content of ancient seawater has been hypothesized to be a major controlling factor for biodiversity throughout Earth's history. The Great Ordovician Biodiversification Event (GOBE) represents one of the largest increases in biodiversity during the Phanerozoic, with peak rates of diversity occurring in the Middle–Late Ordovician. Multiple causal factors have resulted in this long-term ad
