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Context: Dopamine agonists are the treatment of choice for prolactinomas and symptomatic idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment duration is not clear in all details. Objective: The aim of the study was to assess the effect of dopamine agonist withdrawal in patients with idiopathic hyperprolactinemia and prolactinomas. Data Sources: PubMed, the Cochrane

Abstract is not available

By counting the number of upcrossings of the mean level by a stationary Gaussian process one can estimate the mean frequency of the process. If the mean level is unknown and estimated from the observed mean level, then this crossing estimator is more or less biased, depending on the length of the observation interval. It is shown that if the interval is at least two mean wavelengths, then the bias

Surveying Syrian Arabic narrative text, this article explores the use of a switch of verb forms to indicate larger digressions from the main line of a story. The study follows similar analyses of other varieties of Arabic as well as Biblical Hebrew. Isaksson (2007, 2009a) identified specific marking for comments of circumstantial character not only on phrase and clause level but also on text level

The benefits of archaeology are seldom discussed in relation to the evident fascination of many people with the subjects of archaeology and the past. This current popularity of a certain way of perceiving archaeology and the past can be seen as a part of larger trends associated with the Experience or Dream Society as described by scholars such as Gerhard Schulze and Rolf Jensen. In this paper, I

The burial and gathering site Almhov was discovered as a result of large-scale archaeological excavations in southern Sweden revealing the remains of five long barrows, two dolmens and a large number of pits, rich in finds. Given the multitude of activities performed at the site including, for example, monument-building, pit-digging, burying, feasting and axe-manufacturing, the site can serve as a

The paper presents some preliminaryresults on dynamic scheduling of model predictive controllers (MPCs).In an MPC, the control signal is obtained by on-line optimization of acost function, and the MPC task may experience very large variationsin execution time from sample to sample. Unique to this application,the cost function offers an explicit, on-line quality-of-servicemeasure for the task. Base

BACKGROUND: Subclinical myocardial injury has been reported in newborns with fetal weights < 2 SDs for gestational age. Intrauterine growth restriction might affect cardiac function and coronary flow (CF). METHODS: Seventeen newborns with intrauterine growth restriction and 15 age-matched healthy controls were enrolled in the study. Blood flow in the umbilical artery and maternal uterine artery wa

Regression testing is the verification that previously functioning software remains after a change. In this paper we report on a systematic review of empirical evaluations of regression test selection techniques, published in major software engineering journals and conferences. Out of 2 923 papers analyzed in this systematic review, we identified 28 papers reporting on empirical comparative evalua

There is a serious need in the automotive industry to predict surface defects in outer panels. Measures to prevent these defects can not be taken until a test part has been manufactured. This costs a lot in time and money. Within the present project stamping tools for a model part resembling the area around the fuel filler lid was developed. This is an area of the outer surface of a car, which is

Abstract--- This paper follows directly from our forthcoming paper in International Journal of Machine Consciousness, where we discuss the requirements for an artefact to be a moral agent and conclude that the artefactual question is ultimately a red herring. As we did in the earlier paper, we take moral agency to be that condition in which an agent can, appropriately, be held responsible for her

BACKGROUND: Sphingomyelin occurs in modest amounts in the diet, in sloughed mucosal cells, and in bile. It is digested by the mucosal enzymes alkaline sphingomyelinase and ceramidase. In humans, alkaline sphingomyelinase is also secreted in bile. The digestion of sphingomyelin is slow and incomplete, which has been linked to the inhibition of cholesterol absorption and colonic carcinogenesis. OBJE

Activation of the complement system and resulting opsonisation with C3b are key events of the innate immune defense against infections. However, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as C4b-binding protein, factor H and vitronectin, which results in diminished opsonophagocytosis and killing of bacteria by lysis. Another widely us

The main mechanisms of immune defense against Neisseria meningitidis are serum bactericidal activity (SBA) and opsonophagocytosis. Many complement deficiencies, among them acquired partial C3 deficiency due to stabilizing autoantibodies against the alternative pathway C3 convertase (C3 nephritic factors, C3 NeF); increase the risk of meningococcal infection. SBA against meningococci in patients wi

The susceptibility to urinary tract infection (UTI) is controlled by the innate immune response and Toll like receptors (TLRs) are the sentinels of this response. If productive, TLR4 signalling may initiate the symptomatic disease process. In the absence of TLR4 signalling the infected host instead develops an asymptomatic carrier state. The activation of mucosal TLR4 is also influenced by the pro

The present response time study investigated the influence Central Swedish word accents have on the interpretation of inflectional morphology. Effects of stem tone match/mismatch on the interpretation of Swedish present and past tense suffixes were tested. Both Accent 1 and Accent 2 were found to influence listeners' response times related to decisions on verb tense. It thus seems that both word a

BACKGROUND: Oct 3/4 (Octamer 3/4), a member of POU family has been considered as an important stem cell marker and essential transcription factor during human embryogenesis. In recent years, there have also been reports on presence of Oct 3/4 in differentiated benign and malignant human cells. The objective of this study was to investigate the transcription and the protein expression of Oct 3/4 is