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This chapter is a commentary on Principle 1 of the Principles for Responsible Contracts (PRC). The PRC were endorsed by the United Nations Human Rights Council in 2011 alongside the United Nations Guiding Principles on Business and Human Rights. The PRC were drafted because of the potential for investment contracts to act as an instrument through which States and businesses could affect the human
Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associat
The paper presents a computer-based decision support system for watershed planning and flood design purposes including a conceptual rainfall-runoff model. The software package uses up-to-date programing techniques in Windows environment which makes it flexible to handle, adaptable to new areas, and easy to test for different design criteria. The package is suitable for design problems in small as
CONTEXT: Pharmacodynamic studies have shown that persistently high platelet reactivity is common in patients with diabetes in spite of clopidogrel treatment. Clinical trials have not convincingly demonstrated that clopidogrel benefits patients with diabetes as much patients without diabetes.OBJECTIVES: To estimate the clinical effectiveness associated with clopidogrel treatment after myocardial in
This project consists of a thorough study of an energy efficient and moisture safe row-house, located in the Nordic climate of Sweden. Climate and site analysis, building scale design decisions and finally the evaluation and optimization of its energy performance were different steps of a holistic process aiming at the architectural quality, energy efficiency, comfort and the well-being of users.
From the 1880s until the ban of this practice in the 1970s, German vacationers built sandcastles, some of which were artfully decorated and awarded prizes in competitions by the spa administrations. Research regards this as a manifestation of a ‘typical German’ national character. The article counters this approach with an interpretation that understands sandcastles as metaphors for typical charac
Observational learning is a successful method for improving writing skills in various genres. We explore effects of a five lesson intervention series based on peer observation. Fifty-five Swedish 5th-grade students aged 10-12 years followed this intervention program. The language and reading comprehension and working memory capacity were tested. The students watched short film-clips with peers wor
BACKGROUND: The effect of addition of flaxseed flour (10:90, 15:85 and 20:80, w/w) on the chemical composition and starch digestibility of corn tortilla was investigated. Tortillas were baked and frozen in liquid nitrogen, freeze-dried, ground and analyzed for fat, protein, ash, total starch (TS), available starch (AS) and resistant starch (RS) contents as well as for starch hydrolysis rate and pr
Background: We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV). Objectives: To increase detection of HPV among self-samples. Study design: We used a pre-heating step at 90 °C for 1 h on our previously AHPV-negative self-
CONTEXT: Vitamin D (25OHD) is involved in many physiological functions that decline with age, contributing to frailty and increased risk for negative health outcomes. Whether 25OHD is a long-term risk marker for frailty over a longer time and whether it is consistent with advancing age is unclear. OBJECTIVE: To investigate the association between 25OHD and frailty in older women followed for 10 ye
We explore the multiphase structure of the circumgalactic medium (CGM) probed by synthetic spectra through a cosmological zoom-in galaxy formation simulation. We employ a Bayesian method for modelling a combination of absorption lines to derive physical properties of absorbers with a formal treatment of detections, including saturated systems, and non-detections in a uniform manner. We find that i
Using hydrodynamical simulations of entire galactic discs similar to the Milky Way (MW), reaching 4.6 pc resolution, we study the origins of observed physical properties of giant molecular clouds (GMCs). We find that efficient stellar feedback is a necessary ingredient in order to develop a realistic interstellar medium, leading to molecular cloud masses, sizes, velocity dispersions, and virial pa
Governments of different levels have been implementing various policies to enhance the closure of material loops, as well as to reduce the risk of hazardous substances. Manufacturers and distributors of products have a crucial role in the selection and/or verification of materials for their new products. This study sought to obtain concrete knowledge on perception, experiences, and future outlook
We study the problem of distance-based formation shape control for autonomous agents with double-integrator dynamics. Our considerations are focused on exponential stability properties. For second-order formation systems under the standard gradient-based control law, we prove local exponential stability with respect to the total energy by applying Chetaev's trick to the Lyapunov candidate function
Plastics is a group of materials commonly encountered on a daily basis by many people. They have enabled rapid, low-cost manufacturing of products with complicated geometries and have contributed to the weight reduction of heavy components, especially when produced into a foamed structure. Despite the many advantages of plastics, some drawbacks such as the often fossil-based raw-material and the e
