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The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancr

We present a comparative study of solvent effects on the N-15 NMR shielding constants and the lowest electronic excitation energy (n -> pi*) in the three diazines (pyrazine, pyrimidine, and pyridazine) in aqueous solution. This solvent is modeled using either a polarizable continuum model (PCM) or a discrete polarizable model (DPM). We analyze the results obtained with the two models in terms of d

The solvent shift to the fluorescence transition pi* -> n in formaldehyde in aqueous Solution is theoretically analyzed. The solvent model has explicit representation of the solvent and uses the complete active space state interaction (CASSI) method to obtain a description of the wave function of the solute similar to what the complete active space self-consistent-field (CASSCF) method would give.

Near infrared diffuse optical spectroscopy and diffuse optical imaging are promising methods that eventually may enhance or replace existing technologies for breast cancer screening and diagnosis. These techniques are based on highly sensitive, quantitative measurements of optical and functional contrast between healthy and diseased tissue. In this study, we examine whether changes in breast physi

Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, F

Background: Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality. Metho

Introduction. This paper examines and synthesizes previous research in scientific collaboration, scholarly communication, scientific collaboratories, scientific disciplines, invisible colleges and virtual communities to identify factors that may impact the design, adoption and use of a collaboratory within librarianship and information science. Results. A taxonomy of factors that appear to impact

This contribution provides interdisciplinary analysis of expressions of austerity-policies. It is argued that expressions of austerity-policies are meaningful if and only if intended addressees’ psychological states are adequately attuned and conceptual preconditions for implementation met. Furthermore, it is argued that if addressees are suitably psychologically attuned and preconditions met, uti

Context: The incretin effect is responsible for the higher insulin response to oral glucose than to iv glucose at matching glucose levels. It is not known whether this effect is restricted to glucose only. Objective: The aim of the study was to examine whether insulin and incretin hormone responses are higher after oral vs. iv challenge of a lipid emulsion with matching triglyceride levels in huma

New radiative lifetimes have been measured for the 5s (3)P(0,1,2)degrees and 5s (1)P(1)degrees levels of Ge I using a laser-produced plasma subject to selective laser excitation. A diffraction grating based emission spectrometer of moderately high resolution has been used to remeasure the branching ratios of the 4p-5s depopulating transitions. The oscillator strengths of astrophysical interest, wh

Combinatorial libraries and selection of variants from such libraries have proven to be a successful approach for identifying molecules with novel or improved properties. The importance of antibody (Ab) molecules in basic and applied research, as well as the extensive knowledge of how they interact with their antigen (Ag) targets, have made them favorite targets for modification by this approach.

Lifetimes of six levels belonging to the 4f(10)6p configuration of Ho III have been measured for the first time using the time-resolved laser-induced fluorescence method. They are compared with multiconfigurational pseudo-relativistic Hartree-Fock calculations. A very good agreement is found. Using the experimental lifetimes and theoretical branching fractions, a first set of transition probabilit