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Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

Galectin-3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this -galactose-binding protein. Thiodigalactoside (TDG) presents a scaffold for construction of galectin inhibitors, and its inhibition of galectin-1 has already demonstrated beneficial effects as an adjuvant with vaccine immunothera

High-mobility group box protein 1 and its signalling receptors in human preterm and term cervix

The objective of this study was to identify possible changes in mRNA and protein expression of high-mobility group box protein 1 (HMGB1) and its suggested receptors - receptor for advanced glycation end-products (RAGE) and Toll-like receptor 2 (TLR2) and TLR4 - in human cervix during pregnancy, term and preterm labor. Cervical biopsies were taken from 58 women: 20 at preterm labor, 24 at term labo

Beyond the Usual Suspects: Critically Informed Research.

A number of researchers have attempted to define and encapsulate the essence of ‘critical research’. It has been suggested to encompass interpretation of social phenomena, and seeks for understandings that could support efforts to bring about beneficial change. It has been further suggested that such work is characterised by: concern with substantive social issues (e.g. power, values); foundation

Grundämnessammansättning i olika partikelstorleksfraktioner av den atmosfäriska aerosolen

Beskrivning ges av analysteknik (protoninducerad röntgenstrålning), provtagningsteknik (kaskadimpaktor av Battelle-typ) och provberedningsteknik. Utfört arbete i form av provbehandlingsförbättringar, konstruktion och förbättring av provtagare, bestämning av lämpliga analysparametrar samt uppbyggnad av ett dataprogramsystem presenteras. Sammanställning av resultat i form av beräknade medelvärden i

Domsrätt och lagval vid elektronisk handel

Popular Abstract in Swedish Vilket lands domstolar är behöriga att lösa tvister som kan uppkomma till följd av elektroniska avtal där parterna hör hemma i olika länder? Vilket lands lag skall domstolen använda? Även om en svensk domstol är behörig är det inte säkert att den skall använda svensk lag. Dessa frågor sorterar inom ett ämnesområde som heter interationell privat- och processrätt. I avhanThis study addresses some of the private international law perspectives on electronic commerce, namely the matters of jurisdiction and choice of law. Electronic commerce is based on the formation of contracts, and when there are contracts, questions regarding legal issues arise. A distinctive trait of electronic business is that its activities are not bound by geographic borders in a traditional s

The SystemJ approach to system-level design

In this paper, we propose a new system-level design language, called SystemJ. It extends Java with synchronous reactive features present in Esterel and asynchronous constructs suitable for modelling globally asynchronous locally synchronous systems. The strength of SystemJ comes from its ability to offer the data processing and encapsulation elegance of Java, Esterel-like reactivity and synchrony,

The use of routine ultrasound in pregnancy : with special reference to normal and abnormal foetal growth, information and informed choice and the womens' experiences of the prenatal diagnostic aspects

The development of real-time ultrasound in the 1970's made indelible inpact on antenatal care. Assessing foetal growth and detecting deviations from normal in both growth and foetal anatomy became fesible. Expectant parents could also 'see' their foetus. Normal foetal growth parameters at term were consituted and selected parameters from the second trimester were evaluated in the detection of chro

Reliability test-retest of the Nordic Assisted Mobility Evaluation (NAME 1.0).

This paper describes preliminary results from the test-retest of the NAME 1.0. Four scales were tested: Mobility-related participation frequency; Mobility ease/difficulty; Mobility dependence; Extent of assistance in mobility. The test was conducted in the five Nordic countries. In all 147 mobility device users took part in the study, mean age 60 years (range 19 - 93). Each participant was intervi

Is Modernism vs. Postmodernism a Relevant Discussion?

As travellers, we are usually aware that a map is not the territory it represents. However, as researchers, inquiring into practice, are we always aware of the domain within which that practice is situated? Descriptions of practice sometimes suggest that this is not the case. For example, do engineers actually believe that the models they develop and use are reflections of some reality? It is like

Imitatio som pedagogisk princip

Från det vi föds är vi inställda på att lära. Vi iakttar människorna som omger oss och gör som de; vi lär oss tala, samspela, kommunicera. Vi lär genom att imitera. Drivkraften att lära genom efterbildning är något vi använder i retorikundervisningen; våra studenter utvecklar sina egna färdigheter i tal, skrift, läsning och lyssning genom att studera goda exempel och efterbilda dem. Principen kall