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The Swedish Dementia Registry (SveDem) was developed with the aim to improve the quality of diagnostic work-up, treatment and care of patients with dementia disorders in Sweden.

A search for the Standard Model Higgs boson produced in association with a top-quark pair, , is presented. The analysis uses 20.3 fb(-1) of pp collision data at , collected with the ATLAS detector at the Large Hadron Collider during 2012. The search is designed for the decay mode and uses events containing one or two electrons or muons. In order to improve the sensitivity of the search, events are

Since spring 2019 an experimental setup consisting of an electron spectrometer and an ion time-of-flight mass spectrometer for diluted samples has been available for users at the FinEstBeAMS beamline of the MAX IV Laboratory in Lund, Sweden. The setup enables users to study the interaction of atoms, molecules, (molecular) microclusters and nanoparticles with short-wavelength (vacuum ultraviolet an

Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to nd and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mathe

Objectives: This study examines the prevalence of pregnancy in serodiscordant couples and identifies predictors associated with pregnancy in rural Rakai, Uganda. Study design A population-based cross-sectional study that used data from the Rakai Community Cohort Study (RCCS). Setting and participants: We used data from the RCCS survey round 17 (2015-2016), which included 488 women in serodiscordan

Background: Adjuvant chemotherapy (ACT) for breast cancer improves relapse-free survival (BCRFS) and overall survival. Differences in terms of efficacy and toxicity could partly be explained by the significant interpatient variability in pharmacokinetics which cannot be captured by dosing according to body surface area. Consequently, tailored dosing was prospectively evaluated in the PANTHER trial

Islet cell antibodies (ICA) are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. ICA are found in the serum of over 80% of newly diagnosed patients and the levels of ICA are directly of prognostic value. Standardisation of ICA and the uniform reporting of ICA levels in international units is critical to preclinical/clinical research and the development of assays for ICA as diagn

The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of

A search for four-top-quark production, tttt, is presented. It is based on proton-proton collision data with a center-of-mass energy s=13 TeV collected by the ATLAS detector at the Large Hadron Collider during the years 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb-1. Data are analyzed in both the single-lepton and opposite-sign dilepton channels, characterized by the presenc

Background: The functional impact of breathlessness is assessed using the modified Medical Research Council (mMRC) scale for chronic respiratory disease and with the New York Heart Association Functional Classification (NYHA) scale for heart failure. We evaluated agreement between the scales and their concurrent validity with other clinically relevant patient-reported outcomes in cardiorespiratory

Warmer temperatures and the combined effects of wind and water erosion leads to serious soil loss. Identifying the contribution of different drivers to wind and water compound erosion can improve soil erosion management in the watershed. Accordingly, we calculated the erosion energy based on energy theory and applied the mutation test and trend analysis to explore environmental drivers, runoff, an

ABSTRACT: BACKGROUND: The objective of this work is to obtain the correct relative DNA contents of chromosomes in the normal male and female human diploid genomes for the use at FISH analysis of radiation-induced chromosome aberrations. RESULTS: The relative DNA contents of chromosomes in the male and female human diploid genomes have been calculated from the publicly available international Human

Complementary measures for the assessment of patient thermoregulatory state, such as subjective judgement scales, might be of considerable importance in field rescue scenarios where objective measures such as body core temperature, skin temperature, and oxygen consumption are difficult to obtain. The objective of this study was to evaluate, in healthy subjects, the reliability of the Cold Discomfo

AIMS: Lipoprotein lipase (LPL) is a major regulator of triglyceride clearance. A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. The aim of this study was to test whether the phenotypic expression of the LPL Asn291Ser variant

The C-terminal G3 domains of lecticans mediate crosslinking to diverse extracellular matrix (ECM) proteins during ECM assembly, through their C-type lectin (CLD) subdomains. The structure of the rat aggrecan CLD in a Ca(2+)-dependent complex with fibronectin type III repeats 3-5 of rat tenascin-R provides detailed support for such crosslinking. The CLD loops bind Ca2+ like other CLDs, but no carbo

Popular Abstract in Swedish Oberoende av om det är i ett samhälle, datornätverk eller organen i en mänsklig kropp, så är behovet av kommunikation stort i en komplex miljö. Eftersom den komplicerade människokroppen är beroende av kommunikation för att reglera funktioner, skickas otaliga mängder signaler oavbrutet. För att signalerna skall vara meningsfulla så måste de kunna tas emot och behandlas. Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. Since an estimated 50% of all clinical drugs act on 30 known GPCRs, the rem

The short-term evolutionary effect of pheromone-based mating disruption on the mating ability of the Indian meal moth, Plodia interpunctella, was investigated. Three independent selection lines were established, and the mating ability of moths in plastic tents treated with high doses of pheromone and in control tents was compared for two consecutive generations. In addition, the heritability of th

The comminution processes are complex and there has thus far been no, previously published, efficient way to calculate the cost per product and metric ton. The proposed model has been adapted to fit the currently investigated process of crushing and screening (C&S). Deriving from the original model, the proposed new model is presenting the result in cost per metric ton of raw material. It has

Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation