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Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Objective: To explore first-time mothers´satisfaction with their birth experience using Visual Analog Scale and to identify possible risk factors for a negative birth experience.Design: A cross-sectional design using retrospective data collection from electronic medical files.Setting: A birthing center in southern Sweden, which has approximately 1400 births annually.Participants: Primiparous women

IntroductionRecreational hunting in Sweden can be depicted as being embedded in two different but overlapping cultural and socio-economic contexts. One is the traditional non-commercial and stewardship-oriented form hunting, in Swedish called ‘allmoge’ hunting. It is characterised by a democratic hunting tradition where the local hunting team is ascribed a main role in wildlife management. These tThe paper is based on a study of hunting tourism enterprising in Sweden. The study examines how hunting tourism businesses in Sweden navigate in a complex social, economic and moral environment. The aim of the present paper is to identify how tensions between a market- oriented value sphere and a value sphere based on friendship- and community reciprocity are played out in hunting tourism entrepre

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

In today's business environment, organizations rely on information systems to store and process the information constantly gathered. These systems are used to support the everyday needs of the organization. It is apparent that many of these systems has limited or no analytical capabilities, can the introduction of a decision support system could enable practitioners to benefit from this can th

Background The purpose of these studies was to compare efficacy and toxicity of docetaxel alone with the combination of gemcitabine and docetaxel for treatment of metastatic esophageal carcinoma. Patients and methods These studies enrolled patients with histopathologically verified squamous cell carcinoma or adenocarcinoma of the esophagus or cardia. Between March 1997 and June 1999, 52 patients w

Gas turbines, in simple and combined cycle, are common and economically profitable on the power generating market today. Several new cycles have been proposed as future competing technologies, but all studies about these cycles have, so far, been paperwork. The requirements for these new cycles are better efficiency than those of today, provide better flexibility, offer short start up times, less

Bakgrund: Inom arbetsterapi används begreppen aktivitetsbalans och aktivitetsobalans. Det finns ett samband mellan psykisk ohälsa och upplevelsen av aktivitetsbalans, men få studier är utförda på män. Vid psykisk ohälsa kan aktivitetsobalans uppstå vilket kan påverka personens vardag, aktiviteter och hälsa negativt. Syfte: Syftet med denna studie är att undersöka hur män i Sverige med depression