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BACKGROUND/AIM: The value of androgen receptor (AR) in breast cancer has gained renewed interest as a prognostic and treatment predictive biomarker. The aims of this work were to study the associations and the prognostic value of AR in patients from two clinical cohorts.MATERIALS AND METHODS: Cohort 1 included 208 premenopausal, node-negative patients of whom 87% had received no adjuvant medical t
Aims In atrial fibrillation (AF), a relation between electrocardiogram (ECG) parameters such as fibrillatory wave amplitude and stroke has been sought with conflicting results. In this study, we tested the hypothesis that the atrial fibrillatory rate of surface ECG lead V1 is related to stroke risk and may consequently be helpful for identifying high-risk patients. Methods and results Atrial fibri
Purpose - The purpose of this paper is to investigate a strategic change from parallel cell-based assembly (old) to serial-line assembly (new) in a Swedish company with special reference to how production system design elements affect both productivity and ergonomics. Design/methodology/approach - Multiple methods, including records and video analysis, questionnaires, interviews, biomechanical mod
Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the sing
BACKGROUND: Exposure to toxic methylmercury (MeHg) through fish consumption is a large problem worldwide, and it has led to governmental recommendations of reduced fish consumption and blacklisting of mercury-contaminated fish. The elimination kinetics of MeHg varies greatly among individuals. Knowledge about the reasons for such variation is of importance for improving the risk assessment for MeH
In the near future, a new market will form full of 2nd life batteries that are no longer suitable to use in electric vehicles. This since their capacity retention is too low after a few years of usage, as a consequence of two aging mechanisms; cycling aging and calendar aging. These batteries can be put into good use as battery energy storage systems, as the energy density is not as an important f
Under åren 1965-1974 genomfördes en omfattande bostadsproduktion i Sverige som betecknas miljonprogrammet. Då byggdes en miljon bostäder runtom i landet. Idag finns behov av att renovera dessa bostäder. I samband med det kan energisparåtgärder genomföras för att minska energianvändningen. Detta kan uppfyllas genom att åtgärda otäta väggar och byta ut äldre fönster som medför oönskade värmeförlusteIn order to maintain a good indoor environment, air pollutants such as moisture need to be removed by the ventilation. Among the Swedish Public Health Agency's general advices for ventilation and indoor environment, 3 g/m3 is a guideline value for moisture excess during winter months to not pose a risk to human health. The indoor climate parameters moisture excess, relative humidity and air va
Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for
In a non-negligible number of patients with metastatic colorectal cancer (mCRC), the peritoneum is the predominant site of dissemination. Cure can be achieved by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but this procedure is associated with long-term morbidity and high relapse rates. Thus, there is a pressing need for improved therapeutic strategies and co
Background: Per- and polyfluoroalkyl substances (PFAS) are a large family of persistent industrial chemicals with endocrine disrupting properties. Objectives: To examine biomarkers of reproductive function in young adult males according to current environmental exposure to single and combined PFAS. Methods: The study population consisted of young men (n = 1041, age 18–21) from the Fetal Programmin
Introduction: Radiographic progression-free survival (rPFS) by Prostate Cancer Working Group (PCWG) criteria is a radiographic endpoint. The automated bone scan index (aBSI) quantifies osseous disease burden on bone scintigraphy as a percentage of total skeletal weight. Using the aBSI, we sought to quantify increase in tumor burden represented by PCWG progression criteria, and to determine the int
Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in t
Purpose: This study focused on identifying a hereditary predisposition in women previously diagnosed with early-onset breast cancer through a retrospective outreach activity (Traceback). The objectives were to evaluate the possible clinical implementation of a simplified Traceback strategy and to identify carriers of pathogenic variants among previously untested women. Methods: Three hundred and f
Aims: Grading of diastolic function can be useful, but indeterminate classifications are common. We aimed to invasively derive and validate a quantitative echocardiographic estimation of pulmonary artery wedge pressure (PAWP) and to compare its prognostic performance to diastolic dysfunction grading.Methods and results: Echocardiographic measures were used to derive an estimated PAWP (ePAWP) usingAims: Grading of diastolic function can be useful, but indeterminate classifications are common. We aimed to invasively derive and validate a quantitative echocardiographic estimation of pulmonary artery wedge pressure (PAWP) and to compare its prognostic performance to diastolic dysfunction grading.Methods and results: Echocardiographic measures were used to derive an estimated PAWP (ePAWP) using
Introduction: Discordant results between cystatin C and creatinine in estimating glomerular filtration rate (GFR) are an important medical issue. However, the equation that should be used when GFR estimates are discordant remains unclear. Methods: This cross-sectional analysis included 15,485 participants with GFR measured by the clearance of an exogenous marker, serum creatinine, and cystatin C.
On March 30, 2022, Inno4Vac, a public-private partnership funded by the IMI2/EU/EFPIA Joint Undertaking (IMI2 JU), organised a hybrid workshop, titled “Regulatory Dialogue for Road Maps of Implementation of New Tools in Chemistry, Manufacturing, and Controls Dossiers.” This event brought together modellers, regulatory experts, and academic and industry professionals specialising in vaccine process
Multi-electron donation remains a challenge for CO2 photocatalytic conversion to multi-electron products due to the efficient Auger recombination or annihilation at multiple excitation conditions for conventional molecules or semiconductor photocatalysts. In this paper, we demonstrated possible multi-electron donation within a quantum dot (QD)/metal complex hybrid photocatalyst system when multipl
Beaches are important coastal features that provide vital ecosystem services; however, these systems are threatened by coastal erosion, sea-level rise, and coastal squeeze. Beach nourishments are a commonly applied coastal protection measure to mitigate erosion and flood risks while maintaining or enhancing recreational values. Nourishments vary in scale from mega-nourishments to small-scale nouri
The external ventricular drain (EVD) is an important instrument in the management of neuro-intensive care patients through its ability to meassure intracranial pressure and to treat increased intracranial pressure by drainage of cerebrospinal fluid (CSF). However, EVDs are associated with the risk of external ventricular drain related infection (EVDRI). EVDRI diagnosis is challenging as symtoms an
Generella rutiner / regler för laborativ verksamhet inom BMC MILJÖHANDBOK för GEOCENTRUM I LUND Generella råd / rutiner / regler och information för verksamheten inom Geologiska institutionen , GeoCentrum Augusti 2006 www.geol.lu.se/ http://www.geol.lu.se/ INNEHÅLL I Inledning II Byggnad och lokaler III Speciella lokaler IV Elsystem och belysning V Tele/data VI Larm VII Inneklimat och ventilation
https://www.geologi.lu.se/sites/geologi.lu.se/files/miljohandbok.pdf - 2026-07-22
