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BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored

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Biomolecular and pharmaceutical downstream processing is dominated by chromatographic separation, which is associated with high product quality, low capacity and high costs. The separation can be optimized to minimize the costs while achieving a high purity. This paper presents an experimental validation of a discretized multi-level elution (DiME) trajectory, implemented on commercially available

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Cell replacement therapy in Parkinson’s disease (PD) still lacks a study addressing the acquisition of electrophysiological properties of human grafted neural stem cells and their relation with the emergence of behavioral recovery after transplantation in the short term. Here we study the electrophysiological and biochemical profiles of two ventral mesencephalic human neural stem cell (NSC) clonal

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Modelling fire performance of building fire barriers would allow optimising the design solutions before performing costly fire resistance tests and promote performance-based fire safety engineering. Numerical heat conduction analysis is widely used for predicting the insulation capability of fire barriers. Heat conduction analysis uses material properties and boundary condition parameters as the i

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The end-Ordovician extinction consisted of two discrete pulses, both linked, in various ways, to glaciation at the South Pole. The first phase, starting just below the Normalograptus extraordinarius Zone, particularly affected nektonic and planktonic species, while the second pulse, associated with the Normalograptus persculptus Zone, was less selective. Glacially induced cooling and oxygenation a

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Nonparametric efficiency analysis has become a widely applied technique to support industrial benchmarking as well as a variety of incentive-based regulation policies. In practice such exercises are often plagued by incomplete knowledge about the correct specifications of inputs and outputs. Simar and Wilson (Commun Stat Simul Comput 30(1):159–184, 2001) and Schubert and Simar (J Prod Anal 36(1):5

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Twenty-five tree-ring width (TRW) chronologies, developed from moisture sensitive peatland trees in Sweden and Lithuania, and representing eight periods during the mid-Holocene to present, were analysed regarding common periodicities (cycles). Periods of 13-15, 20-22, and 30-35 years were found in most chronologies, while 8-10, 18-19, and 60-65 year periodicities were observed as well, but less co

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Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded rap

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Formation of Maillard products and the influencing factors, which are of crucial importance for both manufacturers and consumers, are still not fully understood. Thus in this study available lysine was used as a marker to monitor the extent of Maillard reactions in freeze-dried, spray-dried and drum-dried skim milk powders during 200 days of storage at highly controlled atmospheres. Storage variab

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Background: In the contact dermatitis literature, it is regularly stated that the patch test reactivity on various areas of the back differs; this might have a large impact on the reproducibility of patch testing. Objectives: To investigate the reproducibility of patch testing on the upper back with regard to the left as opposed to the right side and the medial as opposed to the lateral part of th

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Uppsatsens titel: Kalkylmodeller i affärssystem: Påverkan på varulagervärdering i tillverkande företag. Seminariedatum: 31 maj, 2012 Ämne/Kurs: Examensarbete, Civilekonomprogrammet, inriktning redovisning, 30 HP, uppsats på magisternivå. Författare: Norrlid, Daniel & Åberg, Marcus Handledare: Dergård, Johan & Sandell, Niklas Nyckelord: Affärssystem, produktkalkylering, varulager, varulagerTitle: Costing methods in Enterprise Resource Planning Systems: The effects on inventory valuation in manufacturing companies. Seminar date: May 31, 2012 Course: Master thesis in Business Administration, 30 University Credit Points (30 ECTS) Authors: Norrlid, Daniel & Åberg, Marcus Advisors: Dergård, Johan & Sandell, Niklas Key words: Enterprise Resource Planning Systems, costing methods,

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Uganda’s development-based refugee model is widely recognised as the most progressive in the world by the international community. The model has however come under solid pressure owing to the COVID-19 pandemic, and food insecurity among refugees in the country has become a major problem. This study examines how the pandemic has affected urban and settlement-based refugees’ food security with a par

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This thesis examines how Swedish intelligence actors use intelligence disclosures as strategic communication to address hybrid threats. The study applies a qualitative document analysis to the Swedish Security Service’s and Swedish Military Security and Intelligence Service’s open annual reports and yearly assessments from 2015 and 2024. The material is analysed using Nato’s framework for intellig

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This architectural thesis investigates a general system for a sustainable tourism-related built environment in the Swedish mountains. With a growing interest in hiking and nature-based tourism, the Swedish mountain landscape has become an increasingly popular destination, while at the same time serving as important grazing land for reindeer. This calls for careful development and reduced environme

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Problemformulering: Det ställs alltmer skärpta krav på att förbättra miljö, arbetsmiljö, logistik och ekonomi inom byggproduktion och det krävs därmed att hitta nya metoder som tillmötesgår de nya kraven. Konfektionering har tagits upp som en metod som kan minska byggproduktionens miljöpåverkan och skapa en bättre arbetsmiljö. Om denna metod även kan användas för att effektivisera logistiken och mProblem: In the construction industry there are increasingly higher requirements to reduce the environmental impact and production costs as well as improve the work environment and construction logistics. To meet these new requirements, new production methods are needed. Studies have shown, ready-to-use construction materials can be used in order to improve the environmental impact and the work en

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German forests are in a deteriorating state. The effects of climate change are increasingly showing and presenting society, and also forest owners, with the challenge of restructuring forests to become more climate resilient. At the same time there is a need to halt forest biodiversity loss and to further provide renewable resources that can be used to decarbonise its economy. At present forests’

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Mortgage loan providers estimate the credit risks it caries when approving a mortgage loan to their clients. Further, defaulting a mortgage loan is a risk that has been calculated through decades using statistical models. By using entries at the time of a mortgage application, the goal of the thesis is to com- pare the accuracy between logistic regression and Support Vector Machine in predicting

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Purpose: The purpose of this work is to determine the abundances of neutron-capture elements in solar neighborhood giant stars. This enables constraints to be put on the the cosmic origin of these elements. I have determined abundances of elements produced in both the weak s-process (Cu), the first and second s-process peaks (Y, Zr and La, Ce, Pr, Nd, respectively) and the r-process (Eu, Gd). The