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PURPOSE: Three major glaucoma trials, all using the same Humphrey visual field tests, specified different criteria to define visual field progression. This article compares the performance of these criteria with a reference standard of unanimous classifications by 3 independent glaucoma experts. DESIGN: Longitudinal, comparative study of diagnostic criteria. PARTICIPANTS AND CONTROLS: Two hundred

Understanding the relationships between trait diversity, species diversity and ecosystem functioning is essential for sustainable management. For functions comprising two trophic levels, trait matching between interacting partners should also drive functioning. However, the predictive ability of trait diversity and matching is unclear for most functions, particularly for crop pollination, where in

We have investigated the potential impact on organic aerosol formation from biotic stress-induced emissions (SIE) of organic molecules from forests in Europe (north of lat. 45° N). Emission estimates for sesquiterpenes (SQT), methyl salicylate (MeSA) and unsaturated C17 compounds, due to different stressors, are based on experiments in the Jülich Plant Atmosphere Chamber (JPAC), combined with esti

This thesis presents studies of solar wind-magnetosphere coupling using dynamic neural networks in combination with statistically correlative analysis. The primary contribution of the thesis is dynamic neural network models that can be implemented for near real-time predictions of geomagnetic storms from the solar wind alone. With acceptable accuracy, the prediction time has been extended up to 5

Abstract Sweden has experienced a dramatic change from being a belligerent greatpower in the 17th and 18th centuries to becoming a peaceful small nation in the 19th and 20th centuries. The country has not been involved in war for over 180 years. Modern Sweden has established more or less peaceful relations with other countries. This thesis focuses on the 19th century as beeing an important period

Popular Abstract in Swedish Idag kan vi mäta mycket låga halter av gifter i t. ex. dricksvatten och livsmedel, bland annat genom utvecklingen av nanosensorer. Sensorerna kan också använda's medicinskt, t. ex för att väsentligt underlätta livet för diabetiker. Idag drabba's diabetespatienter ofta av nedsatt känsel i fingrarna på grund av dagliga nålstick. Med hjälp av de nya sensorerna kan vi nu mäA new type of Bioelectronic Nanosensor Device with potential applications in medicine,biotechnology and environmental analysis was designed. The nanosensor is based on RISFET (Regional Ion Sensitive Field Effect Transistor) technology. The design of the nanosensor involves use of a set of nano-sized electrodes on the surface of a silicon chip, giving the chip the ability to sense extremely low con

Agricultural policies have always had a tendency to be controversial. In many cases they generate major transfers of welfare between different groups of people, and hence are favoured by some and criticised by others. They also frequently cause trouble at the international level as domestic programmes interfere with trade flows and affect the wellbeing of people in other parts of the world. In add

Inventory control is a crucial activity for many companies. Given the recent advances in information technology, there have never been greater opportunities for coordinated inventory control across supply chain facilities. But how do we design efficient control methods and policies that take advantage of the detailed information that is now becoming available? This doctoral thesis investigates the

he North Taymyr ice-marginal zone (NTZ) is a complex of glacial, glaciofluvial and glaciolacustrine deposits, laid down on the northwestern Taymyr Peninsula in northernmost Siberia, along the front of ice sheets primarily originating on the Kara Sea shelf. It was originally recognised from satellite radar images by Russian scientists; however, before the present study, it had not been investigated

Fuel economy and emissions are the two central parameters in heavy duty engines; most of the existing heavy duty engines are run with diesel. The overall efficiency of diesel engines is good however they suffer from high levels of emissions mainly NOX and soot. Using alternative fuels like Natural-Gas has shown to be a good way to reduce emissions level. Diesel engines can be easily converted to N

BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati

Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk. Data were obtained from the population-based Goth

There are four paths to a Swedish medical license. A shared agreement exists for those converting from a European license to recognize qualifications granted in the respective countries mutually. Swedish medical graduates and International Medical Graduates (IMGs) trained outside the EU/EES/Schweiz are assessed against the professional qualifications specified in the Higher Education Ordinance (19

The transfer price is the price set by two related parties when transferring products, services, etc between the parties. This thesis examines the Comparable Uncontrolled Price (CUP) method, one of the existing methods to price the transactions. The thesis is written from a Canadian perspective but because of the wide acceptance of the arm's length principle as the corner stone of transfer pri

Electricité de France (EDF) operates a large fleet of nuclear reactors and is responsible for demonstrating the safety of facilities, including concrete containment buildings (CCB), which are non-replaceable components. The leak-tightness of CCBs is assessed every 10 years during integrated leak-rate tests (IRLT). For double-wall containments, which have no metallic liners, the leak-tightness is s

The Internet of Things (IoT) is a large network of connected devices. In IoT, devices can communicate with each other or back-end systems to transfer data or perform assigned tasks. Communication protocols used in IoT depend on target applications but usually require low bandwidth. On the other hand, IoT devices are constrained, having limited resources, including memory, power, and computational

Surrogatmoderskap har sedan mitten av 1980-talet varit omdiskuterat i Sverige i och med att frågan om assisterad befruktning då uppmärksammades, men än så länge är surrogatmoderskap inte tillåtet i landet. I juni 2015 ska det dock publiceras en statlig utredning vilken ska uttala huruvida en legalisering av arrangemanget borde ske och hur detta i så fall ska regleras. Statens medicinsk-etiska rådEver since the middle of the 1980s when artificial insemination was given attention surrogacy have been much-disputed in Sweden, but so far surrogacy is not legal in the country. However in June 2015 a government investigation will be published which will convey whether or not surrogacy should be legalised and if so how the arrangement should be regulated. Statens medicinsk-etiska råd published a

Korruption är ett stort samhällsproblem och offentlig upphandling är ett särskilt utsatt rättsområde när det gäller korruption. Offentlig upphandling rör stora värden i organisationer där det arbetar en mängd människor som på ett eller annat vis kan vara mer frestade att ta emot någon form av belöning eller av ren okunskap bidrar till korruption. Det är inte alltid lätt att veta var gränsen för deCorruption is an immense problem in our society and public procurement is a judicial area, which is especially vulnerable for corruption. Public procurement contains large amounts of money in organizations where the mass of employed in one or another way may be more tempted to accept some kind of remuneration or of pure ignorance contributes to corruption. It is not always easy to know where the l