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The Rieger syndrome is an autosomal dominant disease characterized by ocular, craniofacial, and umbilical defects. Patients have mutations in PITX2, a paired-bicoid homeobox gene, also involved in left/right polarity determination. In this study we have identified a family of genes for enzymes responsible for hydroxylizing lysines in collagens as one group of likely cognate targets of PITX2 transc
Over the past decade, there has been increasing interest in the use of grounded theory in information systems research. Grounded theory is a qualitative research method that seeks to develop theory that is grounded in data systematically gathered and analysed. The purpose of this paper is to suggest guidelines for grounded theory studies in information systems. Our guidelines are based on a framew
The upcoming implementation of the ReFuelEU Aviation Initiative presents both challenges and opportunities for the European aviation sector. Starting January 2025, the EU’s aviation fuel mix must include at least 2% Sustainable Aviation Fuel (SAF), leading to higher operating costs for airlines due to SAF’s higher price than fossil kerosene. Additionally, the entire fuel supply chain will need to
Bilingualism has become increasingly prevalent globally, with about half of the world's population being bilingual by 2012. This growing trend has prompted cognitive research to explore the effects of bilingualism on executive functions. The Bilingual Advantage (BA) theory posits that bilingual individuals experience enhanced cognitive abilities due to their practice in managing multiple langu
Major depressive disorder (MDD) is a prevalent psychiatric condition and poses a significant burden on public health. The underlying causes and mechanisms of depression remain poorly understood. There is a growing body of evidence linking microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal relationship between miRNAs and MDD remains unclear. This study aimed to investigate t
The Iberian Lynx (Lynx pardinus) faces imminent endangerment due to climate change resulting in the declining population of its primary prey, the European Rabbit (Oryctolagus cuniculus). With ongoing environmental shifts, this threat intensifies, heightening the risk of extinction for the species. The aim of this study was to explore a potential conservation strategy; the possibility of relocating
Purpose: The purpose of this study is to investigate the impact of sustainable packaging for cosmetics on consumers within Europe. Methodology: Literature Review, Case Studies, Online Survey Findings: The research conducted exemplifies that sustainable packaging of cosmetic products impacts European consumers’ perception of brand image and influences purchasing decisions. Four key factors from the
Tropical rainforests cover large parts of the Democratic Republic of Congo. In light of recent surges in deforestation in the country, protected areas are a decisive component of the national conservation strategy. Intended to preserve ecosystems, the way in which these areas are organized can have vital implications for people who reside within them through the changes they cause to environmental
Traditionell biologisk näringsavskiljning inom avloppsvattenrening, såsom denitrifikation och biologisk fosforavskiljning (EBPR), kräver tillgång på lättnedbrytbart kol för att bra reningsgrad ska uppnås. Dock är en stor andel av kolet i det inkommande avloppsvattnet partikulärt och måste hydrolyseras innan det blir tillgängligt för bakterierna i den biologiska reningen. Flera studier har studeratTraditional biological nutrient removal (BNR) processes in wastewater treatment require access to easily biodegradable carbon in order to achieve sufficient removal. However, a lot of the carbon in the influent wastewater is not directly available for BNR bacteria but need to undergo hydrolysis first. Several studies have investigated the possibility to produce an internal carbon source from the g
The aim of the project was to develop a methodology for the chromatographic analysis able to identify the key odorants in meaty food products. The approach was based on the analysis of an already in market product and the theoretical background of the meaty flavors sensorially. Firstly, a custom-made flavor was created for the experiments covering as much as possible a broad area of compounds prec
The axiom of transitivity states that if a person prefers option A to B and B to C, he must also prefer A to C. This simple axiom is often seen as one of the pillars of rational choice, but whether it should be has created a divide in the research community. Some state that there cannot be rational choice or utility without transitivity and that agents who present intransitive preferences allow th
To allow further device scalability within the data storage industry there needs to be continued research of new technologies. One promising technology is the Magnetic Random Access Memory (MRAM), based on magnetoresistive elements, which is non-volatile; consume low power and have fast read and write operations. To make the technology scalable, the bit (the smallest element in the MRAM) needs to
Denaturation mapping is a powerful and fast method for optically analyzing DNA molecules.It can be used to characterize DNA molecules on a scale of a few hundred base pairs which is sufficient for applications. Denaturation mapping requires a sufficiently high optical resolution of the imaging system used, which typically translates to an expensive, bulky microscope. For point-of-care testing or u
This thesis explores how Employee-Driven Innovation (EDI) unfolds within Swedish municipal organizations and identifies how EDI is managed and structured, and what kind of innovations that are created in such organizational environments. While innovation is increasingly emphasized in the public sector, this study reveals that its practice is far from uniform. Through qualitative studies of three m
Between 2024 and 2026, AI providers launched dedicated agent products and presented them as tools that can plan, decide and carry out marketing tasks with greater independence than earlier generative AI. On LinkedIn, Swedish marketing executives and industry opinion leaders produce a parallel discourse that reaches the same professional audience. This study examines how the relationship between th
BackgroundNearly 10% of the global population living with dementia resides in South Asia, a region of over two billion people with limited diagnostic and care resources. Clinicians require accessible, flexible, and contextually relevant training to improve dementia care in frontline settings.AimTo develop, pilot, and implement a multi-modal, interactive, hybrid training program to improve clinicia
This thesis explores the conditions to improve collaborative behaviour between organizations in crisis response management. It takes an explorative approach and begins by identifying several challenges to interorganizational collaboration. A systematic review of the international scientific literature in conjuction with semi-structured interviews with crisis management professionals in civil-milit
Popular Abstract in Swedish Ett nytt och experimentellt sätt att bota eller lindra sjukdomssymptom är att, istället för att tillföra en medicin, rätta till felet på en genetisk nivå. Detta kan åstadkommas genom att överföra nya, fungerande gener, sk transgener, till celler som då börjar producera protein, som i sin tur kan ge upphov till en terapeutisk effekt. I hjärnan skulle denna typ av behandlThe use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro
