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Characterising the interaction between cationic ionisable lipids (CIL) and nucleic acids (NAs) is key to understanding the process of RNA lipid nanoparticle (LNP) formation and release of NAs from LNPs. Here, we have used different surface techniques to reveal the effect of pH and NA type on the interaction with a model system of DOPC and the CIL DLin-MC3-DMA (MC3). At only 5% MC3, differences in
Public discourse and political climate policymaking are based on scientific reports and propose technological solutions to solve the crisis, primarily by changing fossil fuels to renewable energy. Rather than questioning growth and the overuse of natural resources—which has been at the core of green concern for decades—green growth is the motor in an economy that aims for continuous economic spin,
PURPOSEAdjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.METHODSWe analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-cons
Background: The emergence of disease-modifying Alzheimer’s (AD) treatments provides new hope to patients and families but concerns have been raised about the preparedness of healthcare systems to provide timely access to such treatments because of a combination of a complex diagnostic process and a large prevalent pool. Objectives: We assess the preparedness of Sweden, a high-income country known
The objectives were to translate the University of Jyvaskyla Active Aging Scale (UJACAS) to Swedish, to establish semantic equivalence and evaluate psychometric properties for use among persons 55 years and older in Sweden. The UJACAS contains 17 items to be self-assessed regarding goals, abilities, opportunity, and activity. Psychometric properties content validity, data quality including floor a
Contaminated sites constitute a global problem as they pollute important freshwater systems at a local scale. To effectively address these sites for remediaton, we must first characterize the sites in order to gain an understanding of the geological setting. This step is crucial as it helps determine groundwater flow pathways and the dynamics of surface water-groundwater exchange within these syst
The cultivated peanut (Arachis hypogaea L.) is an important oilseed crop worldwide, and fatty acid composition is a major determinant of peanut oil quality. In the present study, we conducted a genome-wide association study (GWAS) for nine fatty acid traits using the whole genome sequences of 160 representative Chinese peanut landraces and identified 6-1195 significant SNPs for different fatty aci
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effe
This article takes the awarding of William B. Gartner as a winner of the FSF-Nutek Award (in 2005) as a reason to engage more thoroughly with his production. From the perspective of a European School of Entrepreneurship, we focus in particular on the hermeneutic/phenomenological side of Gartner's research output and seek to operate as inspired readers of this work as we identify its central tenden
Background: Advances in treatment of childhood malignancies have improved overall cure rates to 80%. Nevertheless, cancer is still the most common cause of childhood mortality in Sweden. The prognosis is particularly poor for relapse of high-risk malignancies. In the international INFORM registry, tumor tissue from patients with relapsed, refractory, or progressive pediatric cancer as well as from
Mixed-phase clouds contain both supercooled cloud liquid and ice crystals. In principle, precipitation may be initiated either by the liquid phase or by the ice phase. Ice crystals may grow by vapor diffusion to become snow ("ice crystal process"), forming "cold"precipitation. Equally, cloud droplets, when large enough, coalesce to form "warm"precipitation by the "warm rain process."Warm rain coul
Background: High breast density is an independent risk factor for breast cancer and decreases the sensitivity of mammography. This systematic review synthesizes the international clinical guidelines and the evidence base for screening and supplemental screening recommendations in women with dense breasts. Methods: A systematic search of CINHAL, Embase, and Medline databases was performed in August
IMPORTANCE During the past decade, spinal surgical procedures have been increasingly performed on an ambulatory basis, a change in clinical practice supported only by observational evidence thus far. There have been no randomized clinical trials (RCTs) comparing ambulatory care with inpatient care after any spinal surgery. OBJECTIVE To assess whether ambulatory care is noninferior to overnight hos
The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline prop
Introduction: Although climate change has been consistently identified as one of the greatest threats to humans, many clinicians do not feel prepared to address climate change with patients and medical school curricula still have very little coverage of its health consequences. At the same time, health care providers have been shown to be trusted voices and are therefore well suited to help build
The rheological properties of bituminous binders tested with a dynamic shear rheometer (DSR) as a function of loading time and temperature can more accurately represent real road situations with rising traffic loads and densities combined with climatic change. This method is more effective than traditional methods such as measuring the softening point and penetration. Complex shear modulus and pha
Hypothesis: Low-frequency Raman (LFR) spectroscopy is proposed as a novel non-destructive methodology to probe pH-related phase transitions in self-assembled lipid particles. In this case, dispersed lipid mesophases were composed of ionisable oleic acid (OA) or nicergoline (NG) in monoolein (MO). The sensitivity of LFR spectroscopy to low-energy intermolecular vibrations was hypothesised to be due
Protein drugs, such as therapeutic antibodies, are complex and require careful handling to maintain their efficacy and quality. Stress factors in hospitals, like temperature variations and mechanical shocks during transport, may negatively impact the stability of protein drugs (e.g. various monoclonal antibodies). The pharmaceutical industry possesses extensive knowledge about their product formul
