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The cellular and molecular mechanisms underlying specification of human hematopoietic stem cells (HSCs) remain elusive. Strategies to recapitulate human HSC emergence in vitro are required to overcome limitations in studying this complex developmental process. Here, we describe a protocol to generate hematopoietic stem and progenitor-like cells from human dermal fibroblasts employing a direct cell
During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem
Background : Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. Objective : This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. Design : In the Malmö Diet and Cancer Study, diet
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study"
We studied leukemic stem cells (LSCs) in a Smad4(-/-) mouse model of acute myelogenous leukemia (AML) induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. While HOXA9-SMAD4 complexes accumulate in the cytoplasm of normal hematopoietic stem- and progenitor cells (HSPCs) transduced with these oncogenes, there is no cytoplasmic accumulation of HOXA9 in Smad4(-/-) HSPCs and as a con
Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell growth and survival in a cytokine screen using fluorescently labeled AML cells. RNA-sequencing of the AML cells revealed an IL4-induced upregulation of Stat6 target genes and enrichment of apopt
Adhesion is a key component of hematopoietic stem cell regulation mediating homing and retention to the niche in the bone marrow. Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Knockdown of CYTH1 disrupted adhesion of HSPCs to primary human mes
In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EP
Background: Residual tumor volume (RTV) and extent of resection (EOR) have previously been shown to affect survival in glioblastoma (GB) patients. Quantitative radiological assessment (QRA) of these factors could potentially affect clinical decision-making in the postoperative period. Purpose: The first aim was to evaluate the reproducibility of different volume estimation methods of RTV and EOR b
Korea University Studera utomlands SamhällSvetenSkapliga fakulteten Dina möjligheter Som student vid Lunds universitet har du goda möjligheter att studera utomlands vid ett av våra många partner-universitet. Varje år reser ett stort antal samhällsvetarstudenter iväg på utbytesstudier. Utlandsstudier ger kunskap, vänner och minnen för livet och värdefulla erfarenheter som är till stora nytta när du
https://www.keg.lu.se/sites/keg.lu.se/files/exchange_out_brochure_ht15_sv.pdf - 2026-06-08
ABSTRACT SOCIAL AND ENVIRONMENTAL CONSTRAINTS TO THE IRRIGATION WATER CONSERVATION MEASURES IN EGYPT Thesis submitted in partial fulfillment of the requirements of the Degree of Master of Science at Lund University, Sweden Nino Malashkhia Email: nino.malashkhia.052@student.lu.se November 2003 Supervised by Dr. Per Hillbur Malmö University, Sweden E-mail: Per.Hillbur@ts.mah.se ABSTRACT The present
https://www.lumes.lu.se/sites/lumes.lu.se/files/malashkhia_nino.pdf - 2026-06-08
Rapport från dokumentstudien Evelina Kallträsk Avdelningen för Riskhantering och Samhällssäkerhet LTH, Lunds universitet 29 november 2019 Isf-Projektet: Dokumentanalys Kartläggning av samverkan och samberoenden för sektorerna elektronisk kommunikation, energiförsörjning och transporter Sammanfattning Följande rapport består av en studie som genomförts inom ramen för ett ISF-finansierat projekt ko
SIMM23 FINAL 210301 1 GRADUATE SCHOOL METHODS COURSES SIMM23 Theory of Science for the Social Sciences Version 1.0 – Oktober 2020 SPRING 2021 2 1. WELCOME SIMM23 THEORY OF SCIENCE FOR THE SOCIAL SCIENCES Contact info Graduate School e-mail: master@sam.lu.se Home page: graduateschool.sam.lu.se Facebook: tinyurl.com/LUgradschoolFB Student Union Home page: samvetet.org Lund University Home page: http
https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-03/SIMM23%20FINAL%20210301.pdf - 2026-06-08
Universities and the 2030 Agenda TEACHING, LEARNING AND ACTING ON THE SUSTAINABLE DEVELOPMENT GOALS ACKNOWLEDGEMENTS Many ideas and contributions have been involved in developing this course. A big thank you to the central unit of Lund University Education Board for supporting this initiative, in particular Sylvia Schwaag Serger. Thanks to all those who contributed video material and reviewed the
Microsoft Word - Trädslingan.docx 1 Trädslingan i Botaniska trädgården I södra delen av Botaniska trädgården har vi samlat några vanliga svenska träd och försett dem med faktaskyltar. Här kan man arbeta med att lära sig känna igen träden på deras knoppar och löv. Så här kan man jobba med trädslingan • Tryck ut kartor över trädg
https://www.botan.lu.se/sites/botan.lu.se/files/tradslingan.pdf - 2026-06-08
Författare: Elisabeth Argentzell ”Som en länk mellan patient och personal” Slutrapport 2017-03-01 - Utvärdering av införandet av mentorer som en ny yrkeskategori inom Psykiatri Skåne Förord........................................................................................................................................1 Bakgrund.................................................................
https://www.cepi.lu.se/sites/cepi.lu.se/files/slutrapport-mentorer-inom-psykiatri-skane-170301.pdf - 2026-06-08
Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study ARTICLE Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study Markus Mattila1,2 & Iris Erlund2,3 & Hye-Seung Lee4 & Sari Niinistö2 & Ulla Uusitalo4 & Carin Andrén Aronsson5 & Sandra Hummel6,7,8 & Hemang Parikh4 & Stephen S. Rich9 & William Hagopian10 & Jorma Toppari11
Objective: To determine the relation between concentrations of prostate specific antigen at age 60 and subsequent diagnosis of clinically relevant prostate cancer in an unscreened population to evaluate whether screening for prostate cancer and chemoprevention could be stratified by risk. Design: Case-control study with 1:3 matching nested within a highly representative population based cohort stu
This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. However, strenuous exercise, as perfo
People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic d
