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As the human auditory system is highly malleable in infancy, perinatal risk factors, such as preterm birth, may affect auditory development. In comparison to healthy full-term infants, preterm infants show abnormal auditory brain responses at term age, which may have long-term detrimental outcomes. To achieve an optimal neonatal care environment for preterm-born infants, many early interventions h
På senare år har flera studier visat på att järnhalten ökar i sjöar och vattendrag i norra Europa. Järn spelar en nyckelroll i akvatiska miljöer genom att påverka tillgängligheten av andra näringsämnen i vattnet så som kväve och fosfor, vilket kan reglera tillväxten av växtplankton. Dessutom färgar järn tillsammans med organiskt material vatten brunt. När vattnet blir brunare försämras ljusklimateIron (Fe) concentrations are increasing in freshwaters (lakes and streams) in Sweden, as well as in other regions in northern Europe. Together with increasing concentrations of organic matter, Fe is contributing to the ongoing browning of freshwaters, which may have serious ecological consequences and implications for ecosystem services. The aim of this thesis was to investigated where, to what ex
Aims. The central region of a circumstellar disk is difficult to resolve in global numerical simulations of collapsing cloud cores, but its effect on the evolution of the entire disk can be significant. Methods. We used numerical hydrodynamics simulations to model the long-term evolution of self-gravitating and viscous circumstellar disks in the thin-disk limit. Simulations start from the gravitat
The murine embryonal stem (ES) cell virus (MESV) can express transgenes from the long terminal repeat (LTR) promoter/enhancer in undifferentiated ES cells, but expression is turned off upon differentiation to embryoid bodies (EBs) and hematopoietic cells in vitro. We examined whether a human immunodeficiency virus type 1-based lentivirus vector pseudotyped with the vesicular stomatitis virus G pro
When addressing infants, adults use a speech register known as infant-directed speech (IDS). Compared to adult-directed speech (ADS), IDS has a number of distinctive acoustic and linguistic features. Vowel hyperarticulation, the expansion of the acoustic space between the corner vowels /i,u,a/, is one feature specifically proposed to facilitate language acquisition processes. Interestingly, the pr
The aim of this follow-up study has been to assess retinopathy and change of treatment to insulin therapy as risk factors for mortality in diabetic patients participating in a control and screening programme for retinopathy. A total of 3220 diabetic patients, 483 with an age at diagnosis <30 years, and 2737 with an age at diagnosis ≤30 years, were included. Retinopathy was graded on fundus photogr
Increased population longevity could be influenced by early life factors. Some areas have long-lived populations, also in a historical perspective. We aimed to study these factors in Halland, an area with the highest life expectancy in Sweden. We collected archival data on gestational age and birth characteristics from 995 live singleton full-term births at the Halmstad Hospital, Halland, from the
Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life aft
Popular Abstract in Swedish Många nya läkemedel har en mycket låg löslighet i vatten vilket medför att det behövs stora mängder vatten (ibland 10 tals liter) för att lösa upp en tillräcklig mängd av läkemedlet. Detta gör det till exempel omöjligt att ge medicinen som en injektion direkt i blodet. En möjlig lösning på detta problem är att lösa upp läkemedlet i en s. k. mikroemulsion istället. En miMicroemulsions are thermodynamically stable, transparent solutions of water, oil and amphiphile(s). It is possible to incorporate large amounts of oil in microemulsions, which makes them interesting for use as a drug delivery vehicle for water insoluble drugs. A prerequisite for pharmaceutical use, however, is a low toxicity of the composition. The aim of this thesis has thus been to characterize
BACKGROUND: Solutions of iodine contrast media (CM) used for selective coronary arteriography (CA) should have minimal propensity to cause ventricular fibrillation (VF). Commonly used CM for CA are nonionic monomers or dimers. PURPOSE: To compare VF propensity of ready-to-use solutions of one nonionic dimer, iodixanol, and five nonionic monomers, iobitridol, iopamidol, iomeprol, iopromide, and iov
The object of this study was to investigate whether exposure of pipe-layers to thermal degradation products of diphenylmethane diisocyanate (MDI) could be assessed by analysing 4,4-methylenedianiline (MDA) in hydrolysed plasma and urine, and whether the genotype for N-acetylation affected these biomarker levels. Blood and urine samples were drawn from 30-pipe-layers who had been welding polyuretha
DESIGN: Cross-sectional study. SETTING: University-based rehabilitation center. PARTICIPANTS: Tai Chi practitioners (n=24; age+/-SD, 68.5+/-6.6 y) and control subjects (n=20; age, 71.3+/-6.7 y) were recruited. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Measures included the following: (1) subjects' intentional weight shifting to 8 different spatial positions within their base of support
BACKGROUND: To evaluate resource utilization and direct economic costs of care for patients treated with negative-pressure wound therapy (NPWT), using the Vacuum-Assisted Closure (V.A.C.) system, compared to standard moist wound therapy (MWT). METHODS: A total of 162 diabetic patients with post-amputation wounds (up to the trans-metatarsal level) entered a 16-week, randomized clinical trial. Patie
The method of using short laser and X-ray pulses to investigate dynamics in materials (pump-probe) has been used for several decades. This thesis presents work that was carried out using these sources of light to reveal acoustic, thermal and non-thermal dynamics. The dynamics were induced in the samples by depositing energy with a pulsed laser, and probed with X-ray diffraction. The recent increas
Introduction: The osmotic conductance to glucose (OCG) is a crucial determinant of ultrafiltration (UF) in peritoneal dialysis (PD) patients and can be used to monitor membrane integrity in patients on long-term PD. It has been proposed that OCG can be assessed based on drained volumes in 2 consecutive 1-hour glucose dwells, usually 1.5% and 4.25% glucose, in a so-called double mini-peritoneal equ
Introduction: Given considerable focus on health outcomes among childhood cancer survivors, we aimed to explore whether survivor bias is apparent during long-term follow-up of childhood cancer survivors. Methods: We identified all 1-year survivors of cancer diagnosed before 20 years of age in Denmark, Finland, Iceland, and Sweden. From the general population, we randomly sampled a comparison cohor
Approximately 20% of the population experience long-term pain. Women are generally more affected than men. Currently, pain researchers advocate a biopsychosocial perspective, which emphasises the importance of addressing psychological and social factors as well as biomedical ones in clinical practice. However, previous research shows that this holistic perspective is not always materialized in med
The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat,
Across the world, so-called warlord democrats (WDs) – former military or political leaders of armed groups who subsequently enter formal electoral politics – strongly influence the dynamics and trajectory of post-civil war politics. However, scholarship on war-to-peace transitions and post-conflict politics have often failed to pay attention to the agency of these important actors. This article re
Philosophy played an important role in the Soviet political system becauseit provided ideological legitimization for the regime. Therefore, throughout the existence of the Soviet Union, the authorities and general populations showed a great interest in the works of philosophers. The collapse of the Soviet Union and its Marxist-Leninist ideology led to philosophy’s losing its privileged political s
