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The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases. Chemical inhibitors of Wee1 are currently being tested clinically as targeted anticancer drugs. Wee1 inhibition is thought to be preferentially cytotoxic in p53-defective cancer cells. However, TP53 mutant cancers do not respond consistently to Wee1 inhibitor treatment, indicating the exi
Abraham från Godegård – berättelsen om en originell människa och hans musik bygger på Peter Berrys mångåriga efterforskningar om folkskolläraren Abraham Hagholm (1811-1890). Hagholm var son till en fattig torpare i en avlägsen socken av Östergötland och drabbades i tidig ålder av förlamning. Hagholm övervann svårigheterna i sitt liv genom sin starka vilja och sitt livslånga engagemang i musik. IdaAbraham of Godegård – a tale of originality and music Summarizing a story as wild and ambiguous as this one is a difficult task. My story seems to lack order but is a thorough scholarly study at the same time as being a very personal rendition of how I have proceeded along the road of my research and my search for, and relationship to the subject of my story, the school teacher and musician Abrah
Capacitive biosensors were developed for several analytes such as hormones, interleukines, viruses and heavy metal ions. The sensing surfaces were prepared by immobilizing the biorecognition element to self-assembled monolayers (SAMs) on gold. SAMs form spontaneously on gold by adsorption of thiols, sulfides or disulfides. After immobilization of the biorecognition element a long chain hydrocarbon
Popular Abstract in Swedish Betydelsen av tryckinducerad syrgastransport hos övervattensväxter Min avhandling handlar om vikten av att syrgas transporteras till rötter och rhizom hos övervattensväxter som bladvass, kaveldun och säv. Syrgas behövs för cellandningen i alla växtdelar, och i synnerhet i rötterna då de växer fort och har hög ämnesomsättning. Övervattensväxter har rötterna i vattendränThis thesis examines factors regulating growth and distribution of emergent plants with focus on effects of oxygen supply to the roots. Greenhouse experiments revealed that P. australis acclimatizes to specific water depths with phenotypic plasticity. These phenotypic responses act to increase growth at specific water depths but may result in decreased tolerance to changed water depth. Oxygen nee
Little is known about how microbes diversify in nature. In contrast to the more studied multicellular organisms, microbes can have a) huge population sizes, b) high reproductive rates and c) long-distance dispersal. These characteristics can affect their tempo and mode of diversification in ways that still need to be understood. For instance, it has been proposed that the huge population sizes and
Popular Abstract in Swedish I avhandlingen belyses den inneboende konflikt som finns mellan de två snarlika begreppen jämställdhet och jämlikhet. Detta görs genom att fokusera på svenska kvinnors rätt till jämställdhet i ett formellt jämlikt rättssystem ur ett tvärvetenskapligt feministiskt perspektiv. Det betyder att även om jag har tagit min utgångspunkt i den svenska jämställdhetslagen har jag On the first of January 1992 the present Equal Opportunity Act came into force. A central aim of this law is to improve the conditions of women's working life. One aspect of the law is the possibility to serve as a mean of shifting the balance of power between the sexes. This is meant to be achieved through the inclusion of requirements for active measures to promote equality. As a part of their s
Popular Abstract in Swedish Cytokrom P450 är en grupp enzymer som introducerar alkoholgrupper i främst icke-vattenlösliga ämnen. Alkoholgupperna gör dessa föreningar mer vattenlösliga och känsliga för fortsatta reaktioner. Cytokrom P450-enzymer återfinns i de tre domäner allt levande kan indelas i: eukaryoter (djur, växter, svampar, protozoer m.m.), bakterier och arkeér (ett slags bakterier som skCytochromes P450 constitute a super-family of heme containing mixed function mono-oxygenases that is found in all branches of life. They introduce single oxygen atoms, mostly in the form of hydroxyl groups, into lipophilic substances and thereby render them more hydrophilic and susceptible to further reactions. Little is known about the bacterial cytochromes P450. I have in my thesis given an over
This paper describes the development of a method based on measurements of the radar cross section (RCS) in the forward direction to determine the extinction cross section for the 2.5 – 38 GHz frequency range. A conventional anechoic chamber designed for monostatic measurements is used for forward RCS measurements. The extinction cross section is then calculated from the measured forward RCS using
Popular Abstract in Swedish Kemi finns överallt omkring oss, både i vår omgivning såväl som inuti oss. Vi kanske inte alltid tänker på det, men kemiska processer påverkar oss dagligen och är en förutsättning för vår existens. Det kanske därför inte är så konstigt att människan alltid varit intresserad och fascinerad av just kemi. Ämnet kemi används dock inte bara för att förstå kemiska processer iA considerable part of all chemistry in nature and in industry occurs in solvents. Sol- vents affect both the interactions and the reactions of the particles immersed in them. The work in this thesis concerns the properties of ionic and polar solvents, as well as the interactions between solutes and/or dispersed particles. Molecular simulations and simple approximate theories were used to study th
The purpose of this paper is to provide an ex-post evaluation of the effectiveness of the South Korean Green New Deal (GND) as an instrument to deliver both an economic recovery and improved environmental performance. We use the energy sector as the main scope for our analysis when measured against climate-related indicators (e.g. CO2 emissions, energy intensity, share of renewable energy in suppl
Popular Abstract in Swedish Fibromyalgisyndromet (FMS) karakteriseras av långvarig utbredd värk och smärta, ofta följt av trötthet, stelhet och sömnsvårigheter. Symtomen anses kunna förvärras av fysisk eller psykisk överbelastning. Orsakerna till uppkomsten av FMS är inte kartlagda, men utvecklingen av tillståndet och graden av upplevda svårigheter anses kunna bero på flera sammanlänkande mekanismFibromyalgia syndrome (FMS) is characterised by diffuse, long-lasting, widespread pain and aching, accompanied by fatigue, stiffness and sleep disturbances. The symptoms may be aggravated by physiological and psychological overload. The aim of this thesis was to obtain further knowledge of the functional limitations and disabilities of patients with FMS and to evaluate the effects of physical exer
Individual differences in animal behavior can be attributed to genetic as well as non-genetic influences. One mechanism by which the behavioral phenotype of an individual can be shaped is via transmission of maternal sex steroids. In this study, we examined the role of yolk testosterone (T) in controlling neophobia in 9-month-old, sexually mature zebra finches (Taeniopygia guttata). Offspring hatc
We report on the shear-induced transition from an oriented lamellar phase (L, phase) to multilamellar vesicles (MLV) in two nonionic surfactant systems, namely, a 40 wt % sample of triethylene glycol monodecyl ether (C10E3) and a 40 wt % sample of tetraethylene glycol monododecyl ether (C12E4) in D2O. This transition was studied by time-resolved small-angle neutron and light scattering under shear
Cholecystokinin (CCK) is a potent stimulus of pancreatic enzyme secretion and growth and is known to influence the flow of biliary secretions. It has also been suggested as a trophic stimulus of the biliary tract and liver, but confirmatory studies are lacking. The aim of the present experiment was to study the effects on the rat liver and biliary tract of long-term stimulation of CCK-8S and the C
Dietary sphingomyelin (SM) may have regulatory effects on cell proliferation and tumorigenesis in the colon. Alkaline sphingomyelinase (SMase) is the major enzyme responsible for hydrolysis of SM in the gut. Previously we purified the enzyme and showed that the presence of glycerophospholipids inhibited SM hydrolysis induced by alkaline SMase in vitro. In the present work, we studied the effects o
Today, as a rule, the most cost-effective way to remove nitrogen from municipal wastewater is the biological method based on nitrification and subsequent denitrification. All biological systems may be affected by toxicants, and biological nitrogen removal is no exception. An investigation of influent wastewaters from 109 Swedish municipal wastewater treatment plants was accomplished. Inhibitory s
Popular Abstract in Swedish Redan för 5000 år sedan i det antika Egypten användes ljus för att behandla vissa hudåkommor. Denna bortglömda kunskap återupptäcktes i början av förra seklet men fick inget riktigt genomslag. De senare årtiondenas framsteg inom kemi och fysik har återigen gjort ljusbehandling av sjukdomar högintressant. Speciellt upptäckten av lasern på 1960-talet har gjort att tillämpSince cancer continues to plague humanity there is large need for development of modalities for both diagnosis and therapy. Most of the currently available methods suffer from serious disadvantages. The treatments, e.g. ionising radiation, chemotherapy, surgery, may themselves induce malignancies or the patient may be physically impaired for a longer period of time. The work presented aims at dev
Wider use of oral anticoagulants has led to an increasing frequency of warfarin-related intracerebral hemorrhage (ICH). The high early mortality of approximately 50% has remained stable in recent decades. In contrast to spontaneous ICH, the duration of bleeding is, 12 to 24 hours in many patients, offering a longer opportunity for Intervention. Treatment varies widely, and optimal therapy has yet
In this study, we present a way of controlling the formation of the two types of zeaxanthin aggregates in hydrated ethanol: J-zeaxanthin (head-to-tail aggregate, characteristic absorption band at 530 nm) and H-zeaxanthin (card-pack aggregate, characteristic absorption band at 400 run). To control whether J- or H-zeaxanthin is formed, three parameters are important: (1) pH, that is, the ability to
