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Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neuro
Background: To prevent posterior capsule opacification (PCO), we followed the hypothesis that calcium channel blockers (antagonists) interfere with integrin signaling and block cell adhesion in lens epithelial cells (LEC). In primary human LEC we found that the T channel antagonist mibefradil induces apoptosis which was accompanied with cell shape changes and loss of cell adhesion. Although T-type
Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o
Objective Emotion regulation group therapy (ERGT) has shown promising results in several efficacy trials. However, it has not been evaluated outside a research setting. In order to increase the availability of empirically supported treatments for individuals with borderline personality disorder and deliberate self-harm, an evaluation of ERGT in routine clinical care was conducted with therapists o
The Southern California Borderland is a region that experiences strong natural variations in bottom water oxygen and pH. We use marine sediments from Santa Monica Basin to reconstruct environmental conditions in the basin's bottom water from the Last Glacial Maximum (LGM) to present. We then compare the records to the adjacent Santa Barbara Basin and Santa Lucia Slope. High-resolution records of b
The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation—important for the resilience of the tissue. Another major structural entity particularly impor
Excessive accumulation of leukocytes in the lung represents a key feature in the development of an acute lung injury (ALI). Numerous studies demonstrated that leukocyte rolling is a compulsory precondition for the firm adhesion in organs. However, it seems that the recruitment process of leukocytes in the lung is more complex. Increasing evidence suggests that recruitment of leukocytes in pulmonar
Inom kärnkraftsindustrin är säkerhet den aspekt som prioriteras högst. Alla kärnkraftverk är designade för att i högsta möjliga mån förhindra läckage av radioaktivetet till omgivningen, både under drift och i händelse av en allvarlig olycka. Med anledning av detta är reaktorinneslutningens vägg en av de viktigaste säkerhetsrelaterade konstruktionerna vid en anläggning, detta då denna konstruktionSafety is the top priority at a nuclear facility. The nuclear power plants are designed to prevent radioactive leakage to the surroundings, both during normal operation as well as in case of a severe accident. One of the most important structures in a nuclear power plant, with regard to safety, is thus the reactor containment wall. The containment wall is the last main barrier to prevent radioacti
Although bottom water hypoxia (O2 −1) is presently widespread in the Baltic Sea coastal zone, there is a lack of insight into past changes in bottom water oxygen in these areas on timescales of millennia, and the possible driving factors. Here, we present a sediment-based environmental reconstruction of surface water productivity, salinity and bottom water oxygen for the past 5400 years at Gåsfjär
Peak bone mass is normally reached in the third decade of life. Previously, in the population-based PEAK-25 cohort (n = 1061, age 25.5 ± 0.2), we demonstrated that bone mineral density in the population-based PEAK-25 cohort is comparatively high; therefore, this study aimed to determine if the calcaneus microarchitecture mirrored this. In the process, we describe normative quantitative ultrasound
This thesis investigates the importance of scale for power dynamics in the negotiation of risks connect-ed to Urban Rivers in Nairobi, Kenya. In addition to unequal distribution of wealth, global inequalities in the distribution of risk become increasingly important. Scale as a significant dimension of inequality is discussed in the context of Nairobi’s urban, as water scarcity and flooding events
Bostadsbristen slår hårdast mot dem som redan står längst ifrån bostadsmarknaden. Unga, nysvenskar och äldre har fått det svårare att få sina bostadsbehov tillgodosedda. Det svenska bostadsbyggandet har sedan år 2006 varit lågt i förhållande till befolkningsutvecklingen (Boverket 2015:a). Effekterna av ett lågt bostadsbyggande är bland annat en ökad trångboddhet, osäkra boendeförhållanden, svarthaThe effects of a housing shortage will be hardest on those groups, who are far from being a part of the housing market. It is becoming more and more difficult for young adults, immigrants and elderly to find a solution for their housing needs in Sweden. Since 2006, the rate of construction of housing in Sweden has been relatively low compared to the population growth rate (Boverket 2015:a). The ef
Sustainable development at the local level is greatly impacted by policymaking. In China’s Jingmai Mountain region, the sustainable development policies are centred mostly around the tea industry, due to the social and environmental dynamics surrounding tea in that region. However, considering the complex interlinkages between the tea industry and local environment and society, the policies concer
Traumatic brain injury (TBI) is a common cause of morbidity and mortality in young individuals. Following TBI, the initial injury caused by the head impact is exacerbated by a complex cascade of secondary injury factors leading to increased tissue loss. TBI is an established risk factor for neurodegenerative disorders including Alzheimer disease (AD). In long-term survivors of TBI, increased aggre
Galectins are an old fifteen-member protein family. Every galectin has one or two highly conserved carbohydrate recognition domains (CRDs) through which it binds their mutual ligand galactose. They are involved in various pathways such as signaling, autophagy and immune response. However, they also contribute to pathological functions including fibrosis, metastasis, cardiovascular diseases and dia
Från år 2021 ska alla nybyggnationer i Europa vara nära-nollenergibyggnader. Detta innebär att byggnaders energianvändning bör vara låg och i mycket hög grad tillförs i form från förnybara energikällor som produceras på plats eller i närheten. Syftet med de höga energikraven är att påskynda takten för att skapa ett mer energieffektivt byggande. Den minskade energianvändningen tillsam-mans med en ö
