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BACKGROUND: Klinefelter syndrome (KS) is the most common sex chromosome disorder. The genetic background is the extra X chromosome. Venous thromboembolism (VTE) has been observed among KS patients. The aim of the present study was to examine whether KS is associated with VTE.METHODS AND RESULTS: We followed up all hospital in- and outpatients (N=1085) in Sweden with a diagnosis of KS between Janua
Background:Due to new legislation in 2011 and 2013, the Swedish public healthcare system has undergone change as regards incident reporting and supervision. Focus has turned to learning from adverse events and sharing this learning with actors within the system. The aim of this study was to explore with what underlying safety ontology adverse events in the incident reporting system are investigate
One classic approach to real-time object detection is to use adaboost to a train a set of look up tables of discrete features. By utilizing a discrete feature set, from features such as local binary patterns, efficient classifiers can be designed. However, these classifiers include interpolation operations while scaling the images over various scales. In this work, we propose the use of real value
Den som har det tryggt och bra flyr inte. Vi flyr från svält, fattigdom och politiskt förtryck. När konferensen om prioriteringar i folkvandringens tid hölls 2016 förväntades mellan 70000 och 140000 flyktingar komma till Sverige. Några av dem hade varit med om hemskheter som nog flera av oss i Sverige har svårt att föreställa sig. Många var/är i stort behov av vård på grund av fysisk eller psykisk
Venous thromboembolism (VTE) is major health problem and is sometimes complicated by lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation systems are important risk factors for VTE. Comparative studies suggest that coagulation and innate immunity have a shared evolutionary origin. It is therefore unsurprising that the immune and coagulation systems are linked, with m
OBJECTIVE: We monitored hepatic lipid content (HLC) and fatty acid (FA) composition in the context of enhanced lipid handling induced by a metabolic high-fat diet (HFD) challenge and fasting.MATERIALS AND METHODS: Mice received a control diet (10% of kilocalories from fat, N = 14) or an HFD (45% or 60% of kilocalories from fat, N = 10 and N = 16, respectively) for 26 weeks. A subset of five mice r
Type 2 diabetes (T2D) is associated with deterioration of brain structure and function. Here, we tested the hypothesis that T2D induces a reorganization of the brain metabolic networks that support brain function. For that, alterations of neuronal and glial energy metabolism were investigated in a T2D model, the Goto-Kakizaki (GK) rat. (13)C magnetic resonance spectroscopy in vivo at 14.1 T was us
Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse model with chronic glutathione deficit induced by knockout (-/-) of the glutamate-cy
Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth century the idea that brain energy metabolism is coupled to neuronal activity has emerged, and a number of studies supported this hypothesis. Moreover, brain energy metabolism was demonstrated to be compartmentalized in ne
Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employing (13) C magnetic resonance spectroscopy (MRS) in vivo at high magnetic field, we characterized neuronal and astrocytic pathways of energy met
Detta är den fjärde skriften i en serie som handlar om vetenskap och beprövad erfarenhet. Med hjälp av sakkunniga inom olika områden försöker vi kartlägga begrep- pets betydelse och användning inom olika verksamhetsområden. Tidigare häften har handlat om medicin, juridik och skola.Den som läst dessa häften kan nu skönja vissa mönster. Begreppet vetenskap och beprövad erfarenhet förstås på olika sä
A better understanding of BOLD responses stems from a better characterization of the brain's ability to metabolize glucose and oxygen. Non-invasive techniques such as functional magnetic resonance spectroscopy (fMRS) have thus been developed allowing for the reproducible assessment of metabolic changes during barrel cortex (S1BF) activations in rats. The present study aimed at further exploring th
Combustion and its control are essential to our existence on this planet since we knew it. Nowadays, the largest share of the world’s electricity and most of our transportation systems are powered by combustion. In addition, industrial processes also rely heavily upon combustion. In most industrial combustion systems, combustion occurs under turbulent flow conditions that can produce combustion in
