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BACKGROUND AND AIMS: Atherosclerotic plaques are the leading cause of cardiovascular events. Single-cell approaches have identified diverse human plaque cell phenotypes but their spatial distribution and interactions remain unclear. Here, intercellular communication patterns in human plaque microenvironments were mapped to reveal novel targets to prevent atherosclerotic events.METHODS: Spatial tra

Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better understand how weight discrimination is being argued in Canada’s legal system. The purpose of this environmental scan was to examine and describe Canadi

Context Substantial diagnostic delay in acromegaly contributes to increased morbidity and mortality. Screening attempts in high-risk groups have yielded few positive cases, underscoring the need for simple and precise prescreening methods. Objective Machine-learning analysis of facial images shows promise for acromegaly detection but requires validation in larger, well-characterized cohorts using

Biodiversity offsetting (BO) is aimed to counterbalance biodiversity impacts from development projects. In Sweden, interest in BO within urban planning has grown since the mid-to-late 1990s, when the approach was first piloted in the municipality of Lomma. Because urban planning often involves non-protected nature, BO is not legally mandated but instead implemented on a voluntary basis. So far, ev

Air pollution has become a widespread consequence of human activities, with increasing urbanization and a warming climate shaping its distribution and effects. Organisms with distinct respiratory systems and physiological traits are exposed to multiple air pollutants across human-modified environments, particularly in cities. However, much of our current understanding of how air pollutants affect

A recent retrospective analysis of Enroll HD data suggesting β-blockers slow Huntington's disease progression has triggered patient demand but requires caution. The findings rely solely on small observational subsets and are vulnerable to bias and confounding. A prior Mendelian-randomization study found no causal link between β-blockers and HD onset; instead, genetically higher blood pressure was

Recent research shows that birth order affects human capital outcomes, yet there is limited empirical evidence on the underlying mechanisms. This study examines the effect of birth order on children's time use across activities that are important for human capital development. Using detailed time-use diaries of Australian children aged 2–15, we find that within families with two or three children,

Background: Posterior fossa tumours (PFT) are the most common childhood brain tumours, and children treated for these tumours are at increased risk of persistent speech, language and/or communication difficulties. Such difficulties have often been described in association with the postoperative complication cerebellar mutism syndrome (CMS), but can also occur in children without a period of mutism

This article explores constructions of voluntariness in Swedish district court judgments in child rape cases involving young people in romantic relationships. Drawing on youth research and feminist legal theory, we conducted a reflexive thematic analysis of 38 judgments involving complainants aged 13–14 and defendants aged 15–20. Our analysis resulted in three themes. First, voluntariness was cons

We study time-dependent mediators in survival analysis using a treatment separation approach due to Didelez [Lifetime Data Analysis 25, no. 4: 593–610] and based on earlier work by Robins and Richardson [Causality and Psychopathology: Finding the Determinants of Disorders and Their Cures, 103–158. Oxford University Press]. This approach avoids nested counterfactuals and cross-world assumptions whi

Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorpo

Microplastic (MP) pollution is increasingly recognized as a critical issue in coastal environments, where complex interactions between ocean currents, winds, waves, and human activities govern the transport and deposition of synthetic particles. Although previous studies in Asia have documented MPs accumulation linked to riverine discharge, tourism pressures, and monsoonal circulation, limited wor

The field of high energy physics (HEPs) has seen a marked increase in the use of machine learning (ML) techniques in recent years. The proliferation of applications has revolutionised many aspects of the data processing pipeline at collider experiments including the Large Hadron Collider (LHC). In this whitepaper, we discuss the increasingly crucial role that ML plays in real-time analysis (RTA) a

Background: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is a metastatic condition associated with poor prognosis. Tumor dissemination within the peritoneal cavity is influenced by inflammatory responses, immune activation, and tumor-matrix interactions, particularly following surgical trauma. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC

BACKGROUND: Patients perceive high levels of weight prejudice, stigma, and discrimination within health systems, affecting their ability to manage their obesity and related chronic conditions. Scientific and patient obesity associations worldwide have prioritized the reduction of weight stigma to improve patient experiences in health systems and overall health outcomes. Since a significant proport