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Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the Ndufs4 KO mouse with mitochondrial respiratory chain complex I (CI) deficiency. This study explores NV354, a prodrug of succinate with enhanced oral bioavailability and brain uptake, as a potential therapy to counteract this devastating condition. NV354 modulated whole-bod

The chapter examines the flourishing hagiographical production during the Macedonian age, a period marked by intense rewriting of earlier Greek hagiography. This rewriting culminated in the Metaphrastic menologion, compiled by Symeon Metaphrastes in the late tenth century. Following the end of the iconoclastic controversy until Symeon, a clear progression is attested from an initial monastic inter

Introduction: Chronic pain is among the most common side effects of cancer in cancer patients and survivors, often co-occurring with fatigue, emotional distress and elevated fears of cancer recurrence. Both pain and the associated difficulties are associated with poorer outcomes. Longitudinal studies are needed that identify psychosocial factors that mitigate the effects of chronic cancer-related

This study presents a comprehensive investigation of the structural, microstructural, electrical, magnetic, and magnetoelectric properties of low-level substitution of Co3 + for Fe3+ ions in the perovskite B-site of BiFeO3 (BiFe1−xCoxO3, x = 0.01, 0.015 and 0.02). X-ray diffraction combined with Rietveld refinement confirms the retention of the rhombohedral R3c structure across all compositions, w

Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her

This study provides an in-depth analysis of the impact of a multimodal journey-planning app on users of informal public transport systems in Cochabamba, Bolivia. We analyze survey data (N=648) collected through the Trufi Association NGO's digital travel app on changes in mobility behavior, satisfaction, and everyday life improvements. Participants report more frequent use of informal transport (49

Groundwater-dependent vegetation (GDV) plays a vital role in maintaining biodiversity and ecosystem services in the Mediterranean biome but is increasingly threatened by climate and land use change. Large-scale GDV mapping in arid regions is critical for effective conservation and water resource management but remains challenging due to limited ground-truth data and the lack of high-resolution rem

Den skotska regeringen har åtagit sig att genomföra en rättvis omställning till en klimatneutral ekonomi till år 2045. En viktig del av klimatarbetet inkluderar restaurering av natur, för att minska utsläpp av växthusgaser och öka upptag i koldioxidsänkor. Regeringen driver för ökade privata investeringar i restaurering av natur, genom bland annat generering av kolkrediter. Denna studie syftar tilThe Scottish Government has committed to achieving a just transition to a net-zero economy by 2045. As part of its decarbonisation strategy, it has promoted private investment in nature-based solutions through the development of carbon credit schemes. This thesis examines the extent to which carbon credit schemes in Scotland – specifically the Peatland Code and the Woodland Carbon Code – support a

Trans parenting, scarcely explored in scientific literature, is often treated through the lens of accessibility to procreation technology, state of legislation or experiences of family continuity. A “doing family practice” approach allows us to explore how trans parenthood is conceived in actions for trans parents in France. Through narrative interviews, a “doing family” approach to parenthood, an

Against the backdrop of escalating US-China competition, the Association of Southeast Asian Nations (ASEAN) is situated in a key geopolitical position. This is not the first time ASEAN has faced great power competition within the region. During the Cold War, to respond to the US-Soviet rivalry, ASEAN developed neutrality as one of its fundamental norms. This thesis aims to explore the role and evo

Introduction: The first-line evidence-based treatment for chronic pain is multidisciplinary treatment involving pain-focused CBT. Studies have shown that changes in psychological flexibility (PF) during pain-focused CBT positively mediatesoutcomes, even when the treatment does not specifically target PF. While CBT and PF-based treatments for chronic pain yield small to moderate, but clinically mea

Background: Approximately 40% of cancer patients/survivors develop chronic cancer-related pain (CRP), which is often associated with greater levels of fatigue and cancer worry, all of which are associated with poorer functioning, wellbeing, and greater healthcare costs. Psychological Flexibility (PF) refers to one’s level of openness to and acceptance of physical/emotional experiences and willingn

Background: Prenatal exposure to ambient air pollution has been linked to autism spectrum disorder (ASD), but evidence from low-exposure settings such as Denmark remains limited.Objective: We aimed to examine the association between prenatal exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5), black carbon (BC), and nitrogen dioxide (NO2) and ASD in children, and to identify the most

BACKGROUND: Obesity represents a significant public health challenge, particularly in the context of coexisting chronic diseases and multi-morbidity. In Spain, and specifically in Catalonia, primary care plays a central role in prevention and management, yet barriers such as weight-related stigma can compromise care delivery.AIM: To evaluate the current state of obesity prevention and management w

Emerging evidence and clinical practice guidelines have highlighted that obesity, defined as a chronic disease characterised by excess or dysfunctional adipose tissue, may not be accurately measured or understood by solely relying on body mass index (BMI) which is a measure of size not functionality. An alternative to BMI, as proposed in the Canadian Adult Obesity Management Guideline, is the use

Black carbon (BC) is an air pollutant of emerging concern, and further evidence is needed to understand its health effects. This study investigates the association between gestational BC exposure and birth outcomes, and whether these effects are independent of particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) exposure. We used data from the population-based birth cohort, Maternal

This study examines the sensitivity of mean, high and low streamflows (i.e., Q elasticity) to changes in precipitation (P) and potential evapotranspiration (PET) across South America. The response to P was further assessed by intensifying its seasonal and daily distribution, specifically by increasing (decreasing) P during wet (dry) periods and high (low) events, while maintaining the annual P vol

The European eel (Anguilla anguilla) faces significant challenges during its migratory lifecycle due to anthropogenic habitat fragmentation. Fish passage solutions, such as eel ramps, aim to mitigate such barriers, but their effectiveness varies and may impose selective pressures on eel phenotypes. This study evaluates the impact of ramp design and water flow on the climbing success of juvenile ee