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Psychosocial support and HIV-related stigma intervention needs of adolescents living with HIV in southern Ethiopia : insights from adolescents, caregivers, and healthcare providers

Background: HIV-related stigma interventions targeting adolescents living with HIV (ALHIV) are limited. When available, most of these interventions operate at a single socioecological level and target a single stigma domain, and participatory design is rare. Objective: This study aimed to explore the psychosocial support intervention needs of ALHIV from the perspectives of adolescents, caregivers,

Unraveling the impacts of temperature and vapor pressure deficit on gross primary productivity from current to future scenarios

Elevated air temperature and atmospheric vapor pressure deficit (VPD) are key drivers of plant physiological and ecological processes. However, their relative impacts on vegetation productivity remain difficult to isolate due to the strong coupling between them. This coupling complicates efforts to disentangle independent effects, particularly under compound drought conditions at regional or globa

Managing moral distress : social policy cuts and the suppression of employee conscience

Previous research shows that welfare cuts often cause distress amongst frontline workers. From the perspective of organisations implementing cuts, distressed caseworkers may hinder cost reductions and delay implementation. However, previous research has not analysed whether public agencies seek to reduce the moral distress experienced by their employees. This article examines the reorganisation of

Comparing waist circumference with body mass index on obesity-related cancer risk : A pooled Swedish study

Background General adiposity, assessed by body mass index (BMI), is a well-established cancer risk factor. This study compared waist circumference (WC), a measure of abdominal adiposity, with BMI as a risk factor for obesity-related cancers, and assessed whether WC provides additional information beyond BMI. Methods We analyzed data from 339 190 individuals in a pooled Swedish cohort with baseline

Warming and Reduced Rainfall Alter Fungal Necromass Decomposition Rates and Associated Microbial Community Composition and Functioning at a Temperate–Boreal Forest Ecotone

Changes in temperature and rainfall associated with altered climatic conditions are likely to significantly alter rates of soil organic matter decomposition. To determine how the combined effects of warming and drought impact the decomposition of fungal necromass, a large and fast-cycling portion of the global soil organic carbon (C) pool, we incubated Hyaloscypha bicolor necromass under both ambi

Generative AI in Spectroscopy

Generative AI with spectroscopy is an innovative approach that combines artificial intelligence techniques with spectroscopic analysis, enabling researchers to extract valuable insights from complex spectral data more efficiently and accurately. AI can create high-precision synthetic spectra, enhance signal-to-noise ratios, and support spectral reconstruction by employing deep learning techniques

Disorder-driven non-Anderson transition in a Weyl semimetal

For several decades, it was widely believed that a noninteracting disordered electronic system could only undergo an Anderson metal–insulator transition due to Anderson localization. However, numerous recent theoretical works have predicted the existence of a disorder-driven non-Anderson phase transition that differs from Anderson localization. The frustration lies in the fact that this non-Anders

Generative AI techniques for conformational diversity and evolutionary adaptation of proteins

The advent of AlphaFold and consumer large language models have elicited unprecedented development of artificial intelligence (AI). AI has had substantial impact in every area of research, including in molecular biology. This is principally in thanks to contributions to the Protein Data Bank and various genome sequence databases, providing an astronomical amount of data for model training. These d

Science diplomacy : A global research field? Findings from a bibliometric analysis of the science diplomacy scholarship of the past twenty years

Science diplomacy is a unique research field that is driven and shaped by scholars and practitioners alike. This study examines whether and how recent trends in the broader science diplomacy discourse have impacted scholarship on the topic. First, it examines whether the pertinent scholarship is as international in outlook as practitioners have made science diplomacy out to be. Second, the study i

Ethylcellulose oleogel as a prolonged release delivery system for probiotics. Development and validation of a cold-mixing method

Ethylcellulose thickened oil (EC oleogels) has a significant retarding effect on lipolysis and may be used for controlled-release formulations. However, the high temperature (above 150 °C) used during the gel-forming process becomes an obvious limitation that hinders the application of EC oleogels to temperature-sensitive active ingredients. A cold-mixing procedure that could allow for an encapsul

Tunable Elasto-Viscoplastic Properties of Polymer Blends for 3D Printing Applications

Post-extrusion flow dynamics of soft matter are governed by their elasto-viscoplastic (EVP) rheological properties, which influence filament stability, die swelling, and shape fidelity in extrusion-based 3D printing. Achieving precision and control in printed structures requires optimizing yield stress, viscoelasticity, and extrusion pressure to minimize excessive die swelling and material spreadi

Numerical studies of strong protein interactions

Protein–protein interactions are fundamental to biological functions as well as the design of new functional food products and biomedicines. However, they can be challenging to computationally quantify due to strong forces and sensitivity to pronounced solution conditions. This thesis combines computational methods with Monte Carlo simulations to investigate strong protein interactions in diverse

Integrating ML Approaches for Photodetectors

Optical sensor technologies are central to the advancement of Internet of Things (IoT) ecosystems and smart systems. Among these, photodetectors—a key subset of optical sensors—find extensive applications in areas such as smart sensing, home automation, autonomous vehicles, wearable electronics, and AI-driven platforms. The demand for highly sensitive, cost-effective, flexible, and lightweight pho

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

The androgen receptor (AR) is a critical driver of prostate cancer (PCa). Here, to study regulators of AR protein levels and oncogenic activity, we developed a live-cell quantitative endogenous AR fluorescent reporter. Leveraging this AR reporter, we performed genome-scale CRISPRi flow cytometry sorting screens to systematically identify genes that modulate AR protein levels. We identified and val

Exploring interface tension as a tool to control the morphology of binary organic semiconductor nanoparticles prepared by nanoprecipitation

The ability to control the morphology of organic semiconductor nanoparticles is of paramount importance for applications in organic photovoltaics, photocatalysis, and photo-triggered biological applications. In this paper, we demonstrate that nanoprecipitation is a powerful technique to provide a variety of morphologies in binary blends of organic semiconductors. By investigating seven different d

First mirror stability at the MAX IV soft x-ray beamlines

Horizontal drift of the beam on the MAX IV soft x-ray beamlines was observed with a 1-2 hour settling time and strong dependence on the undulator power setting. A water cooled, suspended electrode was designed and is shown to reduce the horizontal beam drift on three MAX IV soft x-ray beamlines to acceptable operational levels.

Multiple System Atrophy Without Dysautonomia : An Autopsy-Confirmed Study

BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajecto

Journal Club : Endovascular Therapy for Patients With Low NIHSS Scores and Large Vessel Occlusion in the 6- to 24-Hour Window

Endovascular therapy (EVT) has proven benefit for patients with anterior circulation large vessel occlusion (LVO) strokes with moderate-to-severe deficits, but its value in patients presenting 6-24 hours after onset with mild symptoms (NIH Stroke Scale score ≤5) remains unclear. This journal club article examines a retrospective analysis of CLEAR registry data comparing EVT with medical management

Environmental dynamics recorded at Dupljaja loess section (southeastern Carpathian Basin, northern Serbia)

The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the Banat Loess Plateau, Serbia, is of significant palaeoenvironmental importance. Situated within the southeastern Carpathian (Middle Danube) Basin, it provides valuable insights into the climatic evolution during the last glacial period and role of the southeastern Carpathians as a potential migration corridor for early huma