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Summary. This review describes the background for the development of recombinant FVIIa (rFVIIa; NovoSeven) for use in haemophilic patients with inhibitors. The first proof of principle for using pharmacological doses of FVIIa as a haemostatic agent was obtained by producing small amounts of pure plasma-derived FVIIa, which showed encouraging effect in two patients with haemophilia A and inhibitors
Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with d
Background-Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and Results-We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmö Diet and Cancer study.
A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe
Background: Childhood tension-type headache (TTH) is a prevalent and debilitating condition for the child and family. Low-cost nonpharmacological treatments are usually the first choice of professionals and parents. This study examined the outcomes of specific strength training for girls with TTH. Methods: Forty-nine girls aged 9–18 years with TTH were randomized to patient education programs with
This work investigates the concept of autonomy in three contexts: in constitutional law (SA), in the philosophy of Immanuel Kant (KA) and in the contemporary philosophical discussion on personal autonomy (PA). Tracing the concept of autonomy historically, we highlight similarities and dissimilarities between different definitions. For example, Kant’s account of self-legislation is traced back to S
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6
Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable populations, such as participants with mental health issues. We aimed to update understanding of the scope of these problems in trials of health techn
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio
Land use change from agricultural intensification has been highlighted as one of the major drivers of global declines in insects, reducing species diversity and abundance and shifting community composition towards generalist species. However, it remains a challenge to determine how land use change impacts the genetic diversity of species and populations even if this diversity is vital to their lon
The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod
Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact strongly (functional connectivity); through the pattern of anatomical connections (structural connectivity); or simple diffusion. Using magnetoencephalography (MEG), we inves
Kurslitteratur för ENGB03 Engelska: Skriftlig språkfärdighet och akademiskt skrivande på engelska, 7,5 högskolepoäng, HT2014. Fastställd (senast reviderad) av Lärarkollegium 4, 2013-05-23 Notera att angivet tryckår avser den tidigaste upplaga som kan användas. Notera att ISBN-numret bara finns angivet för att hjälpa dig att hitta rätt bok. Om övriga uppgifter stämmer (författare, titel, år, förlag
https://www.sol.lu.se/media/utbildning/dokument/kurser/ENGB03/20142/ENGB03_HT2014_1.pdf - 2026-07-03
The Canterville ghost: from motion capture to real-time virtual reality The Canterville ghost: from motion capture to real-time virtual reality Publicerad den 18 oktober 2024 It started as a question from Riksteatern's sign language ensemble CREA: "Can you help us make an animated character who speaks sign language in real time on stage in our upcoming show about the Ghost of Canterville? It has b
https://www.humlab.lu.se/sv/article/the-canterville-ghost-from-motion-capture-to-real-time-virtual-reality/ - 2026-07-02
Popular Abstract in Swedish Polyomavirus är en familj av små DNA-virus som har onkogena egenskaper i försöksdjur i celler in vitro. De humana polyomavirusen BK virus (BKV) och JC virus (JCV) infekterar en stor del av befolkningen. Ungefär 70-80 % av vuxna är seropositiva, har antikroppar mot BKV och JCV. Primär infektion inträffar oftast under barndomen och är ofta subklinisk. Efter primära infektThe human polyomaviruses BKV and JCV are endemic and infect > 70% of population worldwide. Primary infections occur during childhood and are largely subclinical. Following primary infection, both viruses persist as latent infections in the kidneys and B lymphocytes. Under conditions of severe immunosuppression like leukaemia, organ transplantation and AIDS, the viruses can reactivate and cause dis
Varför samlar LU pengar på hög? Forskare blev ofrivillig spion Utmaning att fylla HT-hus Naturkreatör Lunds universitets magasin | Nr 2 | 2013 utvecklar ytor med vänlig kemi 2 LUM nr 2 | 2013 LUM nr 2 | 2013 3 Yes, your lordship! No, my lady- ship! Chère collegue! Franska och engelska blandas under den fiktiva rättegången där juridikstudenter från hela världen möts för att tävla i EU-rätt. Nyss va
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-2-2013.pdf - 2026-07-03
1 Note: This is an electronic version of an Article published in Business and Society Review 117:2, 233–280 (2012) Corporate responsibility and compliance with the law: land, dispossession and aftermath at Newmont’s Ahafo project in Ghana 1 Radu Mares* Abstract An important part of responsible business practices is compliance with the law. This article details what actually happens when the laws o
https://rwi.lu.se/app/uploads/2012/08/Corporate-responsibility-and-compliance-with-the-law.pdf - 2026-07-03
I april 2019 utfärdades direktiv 2019/790, mer känt som DSM-direktivet. Art. 17 i direktivet riktar sig mot leverantörer av delningsplattformar: stora digitala plattformar där användare laddar upp och delar upphovsrättsligt material, ofta utan tillstånd från rättighetshavarna. Art. 17 gör delningsplattformsleverantörerna ansvariga för användarnas upphovsrättsintrång om de inte erhåller rättighetshIn April 2019, the EU issued directive 2019/790, better known as the DSM Directive. Art. 17 of this directive applies to online providers of content sharing platforms: large, digital platforms, where the users upload and share copyright protected content, often without the rightsholder’s permission. Art. 17 DSM Directive holds the platform providers liable for the users’ copyright infringements, u
Call for Papers Social Europe: Lost in Just Transition? Lund, 1-2 September 2025 The EU is heavily invested in using law and policy as a means to shape a sustainable future. The European Green Deal, the new growth strategy for a more sustainable EU economy, emphasises that the transition to a greener future also needs to be ‘just and inclusive’. Following the European Green Deal, a set of instrume
https://www.jur.lu.se/sites/jur.lu.se/files/2025-02/Call%20for%20Papers,%20Social%20Europe%202025.pdf - 2026-07-03
