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pnas201303829 1..6 Generation of induced neurons via direct conversion in vivo Olof Torpera,b, Ulrich Pfisterera,b,1, Daniel A. Wolfa,b,1, Maria Pereiraa,b, Shong Laua,b, Johan Jakobssona,b, Anders Björklunda,2, Shane Grealisha,b, and Malin Parmara,b,2 aDepartment of Experimental Medical Science, Wallenberg Neuroscience Center, and bLund Stem Cell Center, Lund University, 221 84 Lund, Sweden Contr

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/torper.pdf - 2026-05-24

Popular Abstract in Swedish Det huvudsakliga syftet med den presenterade forskningen var att bygga en förståelse för hur dynamiken mellan professioner, verktyg och objekt fungerar på en operationsavdelning, som ett led i framtagandet av kunskap användbar vid design av framtidens operationsavdelning med fokus på arbetsmiljö, effektivitet och patient säkerhet. Igenom att undersöka hur olika professiThe main objective of the research presented was to gain an understanding of how the dynamics between professionals, tools and objectives work in an operating unit in order to obtain knowledge useful when designing the operating unit of the future with emphasis on the work environment, effectiveness and patient safety. By investigating how different professions in the operating theatre view their

Background: Several attempts to increase the locoregional control in locally advanced lung cancer including concurrent chemotherapy, accelerated fractionation and dose escalation have been made during the last years. As the EGFR directed antibody cetuximab has shown activity concurrent with radiotherapy in squamous cell carcinoma of the head and neck, as well as in stage IV NSCLC combined with che

Popular Abstract in Swedish Föreställ dig ett stort rum med bara en liten fyrkantig, ungefär tio centimeter stor, öppning på en av väggarna. Rummet har fem meter långa väggar och är flera meter högt. Golv, tak och alla andra väggar är helt utan öppningar och är inte genomskinliga. Man misstänker att temperaturen varierar mycket så att det kan vara varmt i en del av rummet och kallt i en annan. DärLight detection and ranging (lidar), a method for nonintrusive, single-ended, and range resolved measurements, has been developed and applied for combustion related diagnostics. Employing picosecond laser pulse durations and detectors providing temporal resolution on the order of picoseconds, lidar has been applied successfully for both quantitative temperature- and species concentration measureme

Popular Abstract in Swedish Denna avhandling handlar om en grupp narkotikamissbrukare som gjort självmordsförsök. Såväl självmord som självmordsförsök är betydligt vanligare bland narkotikamissbrukare jämfört med totalbefolkningen. Bland vårdade narkotikamissbrukare är det mellan 19 till 47 procent som gjort självmordsförsök. Det höga självmordsförsökstalet bland narkotikamissbrukare förklaras oftThe aim of this thesis is to describe suicide attempts in a group of drug abusers who previously had received treatment of their addiction. Another aim is to interpret and analyse the life situations that the individual associates with the suicide attempt. The dissertation is based on interviews conducted on two occasions with 92 drug abusers, 62 men and 30 women. The majority of the drug abusers

Ett medlemskap i EU innebär långtgående rättsliga konsekvenser på nationell nivå. Medlemsstaternas suveränitet är emellertid fortfarande relativt oinskränkt på den direkta beskattningens område, vilket följer av att unionen saknar befogenhet på området och medlemsstaterna således åtnjuter exklusiv kompentens. Medlemsstaterna kan fritt utforma sina skattesystem, men den nationella beskattningsrätteAn EU accession involves far-reaching legal consequences on a national level. Nevertheless, the sovereignty of the member states has remained relatively unrestricted in the area of direct taxation. The Union has no remit of competence in the area and the Member States therefore enjoy exclusive competence when it comes to direct taxation. The Member states maintain the right to design their own tax

Papillomavirus, the leading cause of cervical cancer Papillomaviruses are family of viruses that infect mammals and their uncured infection can lead to cancer. In humans, they can cause as much as 5% of all the cancers worldwide. Even though some papillomavirus types can also cause warts on hands and feet that will clear on its own, some types, regarded as high-risk by specialists, can infect the

In 2016, after decades of armed conflict, the Colombian government signed a peace agreement with the Revolutionary Armed Forces of Colombia – People's Army (FARC - EP). Nevertheless, the hopes for peace have not been realised, since violence, assassinations of social leaders, displacement of local communities and environmental degradation still occur. New groups are taking over the areas forme

Syftet med denna uppsats är att undersöka hur avvägningen mellan effektivitet och rättssäkerhet i förarbetena till skattetillägget kommit att påverka hur dagens skattetillägg fungerar i praktiken vid Skatteverkets kontrollverksamhet avseende tjänsteavdrag. Detta redogörs för genom att dagens regelverk och de förarbeten som legat till grund för skattetillägget analyseras i förhållande till effektivThe purpose of this essay is to investigate how the trade-off between efficiency and rule of law during the legislation processes for the tax surcharge has come to affect how today's tax surcharge works in practice regarding the Swedish Tax Agency's monitoring of tax deductions for work-related expenses made by natural persons. This essay will examine this through analyzing today's reg

Enligt rättsstatsideologin ska den enskilde individen tillförsäkras rättssäkerhet. Det innebär att individen ska skyddas mot övergrepp från statens, eller överhetens, sida genom att staten ålägger sig själv vissa restriktioner i maktutövandet. Proportionalitetsprincipen reglerar statens befogenheter och utgör en del av rättssäkerheten genom att tillvarata individens intressen gentemot staten. EnliAccording to the rule of law ideology, the individual is to be ensured legal certainty. This means that the state should impose restrictions on itself in its exercise of power so that the citizen is protected from the states’ abuse. The principle of proportionality regulates the exercise of powers by the state and forms a part of the rule of law ideology by protecting the interests of the individu

The purpose of this Master Thesis was to design an automatic separator, a machine that would separate organic from non-organic waste through a mechanical process. The use of a mechanical process was one of the target specifications given by WTM AB, the company that initiated the project. WTM is a small machine design company located in Ängelholm, Sweden, who designs machines for different kind of

The 17th September 2001 the distributor Schenker started to cooperate with the computer systems manufacturer Dell to deliver Dell's products to the Nordic market. In the beginning of a new cooperation new processes are formed and they are often developed to solve the local, immediate problems without considering the overall picture. In the distribution network from Dell's plants in Ire

This work has been done for Tetra Pak Distribution (TPD) at the Department of Engineering Logistic at the Lund Institute of Technology. My task was mainly to create a set of simulation models based on the Tetra Pak Distribution Lines. These models are going to be used by TPD to try to analyse the effect of the accumulation systems on the line efficiency. The inputs for the models are failure rate

The aim of this Master’s thesis is to evaluate what possible impact an increased use of groundwater may have on the spread of nitrogen pollution. The work is part of a larger project where Sweco Environment AB assists about 40 farmers in the “Köpinge - Vrams vattenförening” to apply for authorization for groundwater use in agricultural irrigation. The work was performed in three steps: a literatur

The incidence of narcolepsy type 1 (NT1) increased in Sweden following the 2009-2010 mass-vaccination with the influenza Pandemrix-vaccine. NT1 has been associated with Human leukocyte antigen (HLA) DQB1*06:02 but full high-resolution HLA-typing of all loci in vaccine-induced NT1 remains to be done. Therefore, here we performed HLA typing by sequencing HLA-DRB3, DRB4, DRB5, DRB1, DQA1, DQB1, DPA1

The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms of the variance of apparent diffusivities within a voxel. However, the link between the diffusional variance and the tissue heterogeneity is not well-established. To investigate this link we test the hypothesis that diffusional variance, caused by microscopic anisotropy and isotropic heterogeneity, is assoc

Background: Targeted temperature management is recommended after out-of-hospital cardiac arrest and may be achieved using a variety of cooling devices. This study was conducted to explore the performance and outcomes for intravascular versus surface devices for targeted temperature management after out-of-hospital cardiac arrest. Method: A retrospective analysis of data from the Targeted Temperatu

Crop growth simulation models can differ greatly in their treatment of key processes and hence in their response to environmental conditions. Here, we used an ensemble of 26 process-based wheat models applied at sites across a European transect to compare their sensitivity to changes in temperature (-2 to +9°C) and precipitation (-50 to +50%). Model results were analysed by plotting them as impact

IMPORTANCE Prostate cancer commonly metastasizes to bone, and bone metastases are associated with pathologic fractures, pain, and reduced survival. Bone disease is routinely visualized using the technetium Tc 99m(99mTc) bone scan; however, the standard interpretation of bone scan data relies on subjective manual assessment of counting metastatic lesion numbers. There is an unmet need for an object

Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime