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Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. In the work presented in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion pert
Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. Objective To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (A beta 42), total tau protein (T-tau), and tau phosphorylated at po
Aims. Until recently, most high-resolution spectroscopic studies of the Galactic thin and thick discs were mostly confined to objects in the solar vicinity. Here we aim at enlarging the volume in which individual chemical abundances are used to characterise the thin and thick discs, using the first internal data release of the Gaia-ESO survey (GES iDR1). Methods. We used the spectra of around 2000
Popular Abstract in Swedish Stroke är en sjukdom som främst drabbar äldre och är den största anledningen till att människor får olika slags handikapp såsom förlamning och afasi. Det finns ännu ingen effektiv behandling för att lindra symtom och lidande efter en stroke, förutom rehabilitering, och därför kostar stroke samhället enormt mycket pengar. Befolkningen blir allt äldre, vilket även medför Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is
Förevarande uppsats behandlar de utredningar om vårdnad-, boende- och/eller umgänge vilka kan företas i tvister om detsamma. Uppsatsen besvarar frågorna om när och hur reglerna om sådana utredningar tillämpas. Vidare behandlas de brister som finns i utredningar av sådant slag, samt delar av den kritik utredningarna utsatts för. Vid tvister om vårdnad-, boende- och/eller umgänge är vårdnadsutredninThe present essay aims to illuminate the custody reports possible to execute during a custody dispute, when and how the legal rules about custody reports applies, and how the custody report is executed. When a court has to decide if the custody of a child henceforth shall be joint or sole, or where the child henceforth shall live, and in which extent the child shall have right to visitation with t
The health and environmental impacts of food consumption are increasingly recognized as sustainability issues in developed countries. Therefore, promotion of sustainable diets is becoming more popular among governments and International NGOs. However, the question persists of how best to do this. While the determinants of behavioural change have been studied extensively, the motivations behind beh
This thesis addresses the impact of glaucoma on the patients’ vision from both a measurement based and a functionally based perspective. The risk of visual disability is probably the most important question for a newly diagnosed glaucoma patient and maintaining vision-related quality of life (VRQOL) has become the ultimate goal of glaucoma treatment. The objectives of the present thesis were to de
Förorenaren betalar är en ekonomisk princip som internaliserar externa kostnader. Principen är således en metod genom vilken kostnader för förorening kan bli fördelade. Principen kan också beskrivas genom att använda ett rättviseargument, eftersom det kan anses rättvist att förorenaren ska betala för den förorening som han bidragit till. Förorenaren betalar har använts i internationell rätt och anThe polluter pays principle is an economic principle through which external costs can be internalised. The principle is thus a way of allocating costs for pollution. The principle can also be described using a fairness argument, where it would seem fair that the polluter pays the costs for the pollution which he has contributed to. It has been extensively used in international law, and has been re
This thesis has its focus on the interaction between competition law and the public procurement regime. Since the two systems have the same objective of the creation of an internal market it is vital that the two systems reach coherence. Despite this there is now express provision on the importance to fight anti competitive behaviour in the Public Sector Directive 2004/18/EC. On March 28th 2014 th
Background Supply chains in low margin, high innovation speed industries with strong customers generate a highly competitive environment. The conditions for such environment are continuously changing and put high demands on its actors. FlatFrog is a case company, which was founded in 2007 and develops a unique touch technology targeting a wide range of screens sizes and applications. External capi
One of the cleanest ways of transporting goods is at sea. However, the emissions from ships increase and with a wider knowledge about the environmental consequences caused by the emissions, requisite regulations are needed. This thesis deals with air emissions of sulphate (SOx) - and nitrogen oxides (NOx). These emissions cause negative environmental effects both by direct pollution and by forming
The maritime transportation of hazardous cargo has created a sometimes intense dispute between the shipping industry and coastal states. The arguments feeding this discussion are the right of innocent passage, claimed by shipping states, and on the other hand, the obligation to protect the environment stressed by coastal states. Two sets of rules, both codified in international law, stand in confl
Tutors: Stefan U Klingberg, Director Strategic Planning, Scania CV AB Ulf Paulsson, Ph.D in Engineering, Department of Business Administration Malin Olander Roese, Department of Design Sciences, LTH Issue of study: Services dominate the economy of today why it becomes essential for companies to add value through services. Still many companies fail to do so. The main reason is existing knowledge
Populärvetenskaplig sammanfattning: De begravda jordmånsbildningarna vid Sandhammaren och Skanörs ljung, södra Sverige, är lokaliserade inom kustnära dynlandskap som har bildas i response till land-och havsnivåförändringar efter den sista istiden (efter ca. 10 000 år sedan). Jordmånerna är begravda av flygsand och karakteriseras av flera organiska lager med tillhörande urlaknings-och anrikningshorThe palaeosoils at Sandhammaren and Skanörs ljung, southern Sweden, are located within a coastal dune landscape that developed in response to Holocene land/sea changes. These buried soils are characterised by several organic layers including pedological horizons. They were studied for fossil pollen, and soil chemistry (iron, aluminium, manganese, phosphorous, carbon and pH) in order to appreciate
The success of social movements is highly dependent on their sustainability, as in their efforts to produce meaningful change, they inevitably encounter oppressive dominant forces. With the advent of the social media era, scholarly research on collective action has acquired an additional dimension, bringing the role of their communicative constitution to the forefront of discussions. However, a de
Monoclinic β-Ga2O3 films grown on c-plane sapphire have been shown to exhibit six (2¯01)-oriented domains, which are equally spaced by rotation around the surface normal and equally sized by volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry data
Genom freden i Roskilde 1658 kunde Sverige tillskansa sig det tidigare danska Skåne. Fredsavtalet garanterade skåningarna rätten till, bland annat, dansk lag och tidigare danska privilegier. Statens arbete mot uniformitet i provinsen, genom att försvenska området, tog dock sakta men säkert vid, och 1683 var arbetet utfört och uniformiteten införd. Huvudsyftet med uppsatsen har varit att klargöra vIn 1658, the former Danish region of Scania was ceded to Sweden due to the Treaty of Roskilde. The treaty also guaranteed the Scanian population its right to maintain their Danish law and retain their former Danish privileges. Despite this, the state soon started to work towards uniformity between Scania and Sweden by a process known as Swedification, a process which was completed in 1683. The mai
Lag om tillfälliga begränsningar av möjligheten att få uppehållstillstånd i Sverige (benämns fortsättningsvis som den tidsbegränsade lagen) trädde i kraft 20 juli 2016 och innebär att möjligheten för alternativt skyddsbehövande att återförenas med sin familj i Sverige begränsas avsevärt. Familj till alternativt skyddsbehövande har endast rätt till uppehållstillstånd om nekandet av familjeåterförenThe temporary law of limitations regarding the possibility of being granted residence permit in Sweden (latterly known as the temporary law) took effect on July 20, 2016. It severely limits the possibility for persons eligible for subsidiary protection to be reunited with their family in Sweden. Family belonging to persons eligible for subsidiary protection only have the right to obtain a residenc
Fjärrvärme har en betydande roll i det svenska energisystemet där många är beroende av att systemet ska fungera optimalt. Trots den generellt höga leveranssäkerheten i dagens system är oplanerade leveransavbrott är något som sker tidvis. I Sverige började många fjärrvärmenät byggas ut i mitten av 1900-talet och mängden skador i äldre ledningar förväntas öka med tiden. Att ersätta gamla ledningar iDistrict heating plays a significant role in the Swedish energysystem where many are dependent on the district heating working optimally. The system in general has a high security of supply, but unplanned interuptions in the supply do ocasionally occur. Many of the district heating networks in Sweden began construction in the middle of the last century and some of the old pipes are expected to see
Examensarbetet jämför tre olika metoder för dimensionering av en spont. Syftet med arbetet är att utreda hur de valda beräkningsmetoderna inverkar på dimensionerande snittmoment och dimensionerande förankringskrafter samt att undersöka hur resultaten från de olika beräkningsmetoderna varierar vid ändring av ingående parametrar. De tre beräkningsmetoder som jämförs är den analytiska metoden från SThis master thesis compares three different methods for dimensioning a sheet pile wall. The purpose is to investigate how the chosen calculation methods affect dimensioning moments and anchoring forces in a sheet pile wall and to investigate how the results from the different calculation methods vary when changing the input parameters. The three calculation methods that are compared are the analy
