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The identification and classification of bacteria was initially performed with morphological methods applied on cultivated bacteria. It was not until the mid 1970s, when sequences of ribosomal RNA were discovered to be useful for bacterial evolution, that a new era started. This method showed to be far more accurate for bacterial identification. Today, identification of bacteria is totally dominat
The purpose of this study is to dissect the process of ideological orientation in the public debate of postwar Sweden. Crucial to the study is the idea of a generic totalitarianism; a concept used both on a scholarly and a political level, focusing on the similarities between communism and Nazism, and the diverging guiding potential of this totalitarianism idea in different times and situations.
Popular Abstract in Swedish 2003 års Nobelpris i kemi gick till professor Peter Agre för upptäckten av aquaporinerna. Aquaporiner är proteiner som sitter i membran och bildar kanaler som tillåter vatten och andra små neutrala molekyler att passera genom membranet. Aquaporinerna utgör en mycket gammal och välkonserverad proteinfamilj som finns i alla levande organismer som hittills undersökts. VäxAquaporins, or Major Intrinsic Proteins (MIPs), are integral proteins that facilitate transport of water and other small neutral solutes across biological membranes. They belong to a well conserved and ancient family of proteins, present in all organisms ranging from bacteria to plants and humans. The aquaporin family in plants is large, indicating complex and regulated water transport within the
Nuclear magnetic resonance (NMR) spectroscopy was used in order to investigate the relationships between structure, dynamics and calcium binding in the intracellular regulatory protein, calmodulin. Calmodulin consists of two similar domains, each binding two calcium ions with positive cooperativity. The studies described in this thesis focus on the isolated C-terminal domain, TR2C, and two mutants
Abstract in UndeterminedEconomic development that includes investments in infrastructure and buildings requires energy intensive basic materials such as steel and cement. The production capacity of these industries is also growing most rapidly in developing countries [WEC, 1995 #41]. Energy intensive industries typically account for a relatively small share of the value-added in industry but a rel
Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabo
During thermomechanical processing of metals, changes occur in the microstructure of the material which affect its macroscopic properties. By understanding these transformations in the microstructure, it becomes possible to design the processes in a way which yields the desired properties in the finished product. For this purpose, computer simulation plays an increasingly important role.The presen
The emergent nature of the innovation process has always rendered it an elusive subject of study. Nonetheless, academics remained undeterred in their attempts to articulate the innovation process in academics terms as attested by the growing amount of research on the topic. Existing theories for explaining innovation (or the lack of innovation) center on empirical samples from large firms in the h
Background: The FRAX® algorithm quantifies a patient's 10-year probability of a hip or major osteoporotic fracture without taking an individual's balance into account. Balance measures assess the functional ability of an individual and the FRAX® algorithm is a model that integrates the individual patients clinical risk factors [not balance] and bone mineral density. Thus, clinical balance measures
Huntington's disease (HD) is a fatal, autosomal dominantly inherited neurodegenerative disorder, characterised not only by progressive cognitive, motor and psychiatric impairments, but also of peripheral pathology. In both human HD and in mouse models of HD there is evidence of increased energy expenditure and weight loss, alongside altered body composition. Unlike white adipose tissue (WAT), brow
Plant species sometimes perform extraordinarily well when introduced to new environments, through achieving higher growth rates, individual biomasses or higher densities in their receiving communities compared to their native range communities. One hypothesis proposed to explain enhanced performance in species’ new environments is that their soil microbial communities may be different and provide
Popular Abstract in Swedish Avhandlingen är en sammanläggningsavhandling, bestående av fem artiklar, kring hur finansiella behov hanteras i nya och små företag. Den empiriska datan har insamlats genom två enkätstudier och en fallstudie. Det viktigaste bidraget i avhandlingen består i utvecklingen av begrepp som gör det möjligt att förstå s.k. finansiell bootstrapping i nya och små företag. Med finThe overall aim of this composite thesis, consisting of five articles, is to develop concepts for furthering the understanding of small business managers´ handling of finance. The main contribution is the development of a conceptual understanding of so-called financial bootstrapping behavior in small businesses (referring to the use of methods for minimizing and/or eliminating the need for financi
Popular Abstract in Swedish Titeln på den här avhandlingen är ”Nukleinsyror som läkemedel och mål för läkemedel, med fokus på anticanceraktiva platinaföreningar och små interferande RNA”. Nukleinsyror är mer kända som sina förkortningar DNA och RNA. Anticanceraktiva platinaföreningar är en typ av läkemedel mot cancer. Små interfererande RNA är en slags reglermekanism för hur mycket av ett visst pr
Popular Abstract in Swedish Arbetet i denna avhandling presenteras i 6 olika delarbeten (artiklar I-VI). Artiklarna I-III behandlar två olika enzymer som bryter ner cyklodextriner, vilka är ringformade molekyler med samma beståndsdelar som i stärkelse (dvs sammanlänkade glukosmolekyler). Dessa s.k. cyklodextrinaser kommer ursprungligen från två bakterier som har isolerats i varma källor på Island.Two putative cyclodextrinases (CDases) were amplified from two moderate thermophiles isolated in Iceland: Anoxybacillus flavithermus and Laceyella sacchari. They were cloned, expressed and characterized. The expression of the former was optimized in E. coli by using a solubility-enhancing tag, NusA, and tuning of inducer concentration in the expression strain Tuner(DE3). The CDases were optimally
Popular Abstract in Swedish Beständiga organiska miljögifter, till exempel PCB (Polyklorerade bifenyler), har vållat stora miljöproblem i flera decennier. Dessa föroreningar är kemiskt och biologiskt sett väldigt stabila, vilket gör att de bryts ner mycket långsamt i miljön och alltså kan transporteras långväga med vindar och strömmar. Därför kan man hitta PCB över hela jorden, även i områden där Persistent organic pollutants (POPs) pose serious threats to our global environment. These compounds have high chemical and biological stability and they are also very lipophilic. These characteristics not only render POPs the ability to spread widely and pollute remote areas, they also make them prone to accumulate in adipose tissues of living organisms. Consequently, it is important to monitor P
Laparoscopic surgery was introduced to minimize patient trauma. However, fatal technique specific complications, due to major vascular or visceral injury, were at times seen related to blind abdominal access using the Veress technique. A modified open access technique was developed and evaluated in 100 patients and found to be fast and easy to learn with few associated complications. This open te
Popular Abstract in Swedish Företagen har mer och mer problem att generera och utveckla kunskaper i samarbete med andra, enskilda företag. Forskare inom det teoretiska område kooperativ inlärning har börjat att undersöka hur partnerorganisationer lär sig att samarbeta med varandra. Men det specifika inlärningsinnehållet av denna kollektivt inlärda kunskap är generellt inte något de fokuserar på. DBusiness organizations increasingly face the problem of how to generate and share knowledge in collaboration with other, separate, business organizations. Researchers in the field of inter-organizational learning have started to study the partner-characteristic, partner-dynamic, and partner-situational factors that influence the process and outcome of such strategic learning collaboration. However
