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Background and aims: Anti-alpha 4 integrin therapy with natalizumab is efficacious in refractory Crohn's disease and in multiple sclerosis, but carries an estimated 1/1000 risk of progressive multifocal leukoencephalopathy (PML) caused by reactivation of latent JC virus infection. Athough anti-alpha 4 integrin therapies are likely to be introduced in the clinic, screening for the risk of PML has n

In this paper, we show how studies of fracture mineral paragenesis, their orientation and Ar-40/Ar-39 geochronology can be applied in order to recognise the brittle tectonothermal evolution in an area. Samples were selected from nearly 18 km of drill cores from the upper I km of the Fennoscandian Shield obtained during the site investigation for a repository of spent nuclear fuel in Forsmark, cent

Popular Abstract in Swedish Akut pankreatit (AP) är en inflammation i bukspottskörteln, som oftast utlöses av gallstenssjukdom eller alkoholintag. Varför man får akut pankreatit vet man inte och inte heller varför de flesta patienter återhämtar sig på ett par dagar, medan ca 20 procent drabbas av en betydligt svårare form av sjukdomen. Vid svår AP ses en kraftig inflammatorisk reaktion i hela krop

Several high resolution electrophysiological techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. The presence of ATP sensitive channel on the cell membrane permitted the electrical detection of minute (amoles) quantities of A

Context: Newly discovered biomarkers ideally should prove clinical usefulness, provide additional detection, staging, and prognosis information to improve individual risk assessment, and potentially permit targeted cancer therapy. Objective: To review, display, and evaluate the current evidence regarding the biologic and analytic approach of urinary prostate cancer gene 3 (PCA3) in prostate cancer

Popular Abstract in Swedish Skolämnet livskunskap har vuxit fram i svenska skolor under det senaste decenniet, ofta utifrån en ambition att främja hälsa och att konkretisera skolans värdegrundsarbete. Avhandlingen belyser hur livskunskap växer fram och definieras som ett skolämne i nationella och kommunal dokument, och organiseras i lokal skolpraktik. Studien, som har en kombinerad barndomssocioloThe aim of this thesis is to understand and cast light over how the school subject Life Competence Education (Sw. Livskunskap) is developing in the Swedish school context. In focus of the study is how this school subject is defined and organized by actors (i.e. politicians, national governmental institutes, local governmental authorities, teachers and children in compulsory schools) in the differe

Preeclampsia is one of the most serious pregnancy-related diseases and clinically manifests as hypertension and proteinuria after 20 gestational weeks. The worldwide prevalence is 3-8% of pregnancies, making it the most common cause of maternal and fetal morbidity and mortality. Preeclampsia lacks an effective therapy, and the only "cure" is delivery. We have previously shown that increased synthe

Popular Abstract in Swedish Bostäder med särskild service som upplevs ge möjlighet till socialt umgänge, avskildhet och återhämtning har positiva effekter på livskvaliteten hos människor med psykisk funktionsnedsättning. Vidare visar resultaten från denna avhandling att den visuella upplevelsen av miljön och upplevelsen av hemlikhet är betydelsefulla för att etablera en stödjande atmosfär. Boendem

One of the big obstacles for understanding the nervous system is its inherent complexity. It poses problems when interpreting both experimental and theoretical studies since we are currently forced to consider only reduced variants of the actual circuitry of the brain. Since there exist problems that do not appear until a system is sufficiently complex, there are no guarantees that the results ste

This article sets out to study the ways in which reactions and adaptations to modernity and societal change among non-elite communities in late nineteenth-century Sweden are visible in contemporary attitudes to social deviants and nonconformists. In Swedish provincial cultures, narratives about local characters in the oral tradition played a significant part in regional identity formation in the n

The survival rates among testicular germ cell cancer (TGCC) patients have dramatically increased and more than 95 % are cured. The question of quality of life of the survivors is, therefore, important. The TGCC treatment, and thereby its side-effects may vary. A contributing factor to this variation is also genetically determined inter-subject difference in the sensitivity to the adverse effects o

Purpose The purpose of this study is to better understand online anonymity in the global file-sharing community in the context of social norms and copyright law. The study describes the respondents in terms of use of Virtual Private Networks (VPNs) or similar services with respect to age, gender, geographical location, as well as analysing the correlation with file-sharing frequencies. Design/me

Immune system functioning and maintenance entails costs which may limit investment into other processes such as reproduction. Yet, the proximate mechanisms and 'currencies' mediating the costs of immune responses remain elusive. In vertebrates, up-regulation of the innate immune system is associated with rapid phagocytic production of pro-oxidant molecules (so-called 'oxidative burst' responses).