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BACKGROUND: The role of adenomatous polyposis coli (APC) gene in mitosis might be critical for regulation of genomic stability and chromosome segregation. APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.METHODS: We invest
Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes. These barcodes can be mapped to theoretical counterparts obtained from DNA reference sequences, which in turn allow for DNA identification in complex samples and for detecting structural changes in individual DNA molecules. Ther
In this study we combine for the first time silicon (Si) isotope compositions of small mixed diatom species (δ30SibSiO2) and of large handpicked mono-generic (i.e. genus=Coscinodiscus) diatom samples (δ30SiCoscino) with diatom assemblages extracted from marine sediments in the Peruvian upwelling region in order to constrain present and past silicate utilisation. The extension of a previous core-to
In boreal summer, circumglobal Rossby waves can promote stagnating weather systems that favor extreme events like heat waves or droughts. Recent work showed that amplified Rossby wavenumber 5 and 7 show phase-locking behavior which can trigger simultaneous warm anomalies in different breadbasket regions in the Northern Hemisphere. These types of wave patterns thus pose a potential threat to human
Failure in wood is commonly considered as a sign of properly chosen adhesive for wood adhesive joints. It is argued that as the adhesive is stronger than the surrounding wood material, no concern has to be given to the adhesive properties in joint design. However, by means of theoretical arguments in combination with experimental experience in the present study, it is stated that local bond line p
