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AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. However, the hypothesis that CFTR has a direct role in the endocrine pancreas has no
Imitation is a cornerstone in human development, serving both a cognitive function (e.g. in the acquisition and transmission of skills and knowledge) and a social-communicative function, whereby the imitation of familiar actions serves to maintain social interaction and promote prosociality. In nonhuman primates, this latter function is poorly understood, or even claimed to be absent, yet the evid
Given the strong coupling between the carbon (C) and nitrogen (N) cycles, there is substantial interest in understanding how N availability affects C cycling in terrestrial ecosystems, especially in ecosystems limited by N. However, most studies in temperate and boreal forests have focused on the effects of N addition on tree growth. By comparison, less is known about the effects of N availability
Architectural trends increasingly challenge material producers and engineers to create sustainable, renewable and innovative laminated glass products that combine multiple functions as in, for example, glass railings with solar cells, curved laminated glass, floors with light emitting diodes that serve as multimedia screens. All new tendencies require the development of interlayers for lam
The WORLD6 model is a fully integrated dynamic world systems model. It includes a biophysical global economic model, based on first principles of physics and thermodynamics, forcing it to be fully consistent with the underlying mass- and energy balances. The WORLD6 model first creates value from extraction of natural resources, input of human labour, the efficiency effect of mechanization and auto
